Ech1 enoyl coenzyme A hydratase 1, peroxisomal [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ech1provided by MGI
Official Full Name: enoyl coenzyme A hydratase 1, peroxisomalprovided by MGI
Primary source: MGI:MGI:1858208
See related: Ensembl:ENSMUSG00000053898 AllianceGenome:MGI:1858208
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable delta3,5-delta2,4-dienoyl-CoA isomerase activity. Predicted to act upstream of or within fatty acid metabolic process. Located in mitochondrion. Is expressed in several structures, including adrenal gland; alimentary system; liver; and nervous system. Orthologous to human ECH1 (enoyl-CoA hydratase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in heart adult (RPKM 764.2), kidney adult (RPKM 330.1) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B1; 7 16.94 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (28524763..28531664)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (28825338..28832239)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Enoyl coenzyme A hydratase 1 alleviates nonalcoholic steatohepatitis in mice by suppressing hepatic ferroptosis.
Title: Enoyl coenzyme A hydratase 1 alleviates nonalcoholic steatohepatitis in mice by suppressing hepatic ferroptosis.
ECH1 regulated the thermogenic program by inhibiting mammalian target of rapamycin signaling, which may partially explain the potential mechanism for ECH1 regulating adipose browning
Title: Enoyl coenzyme A hydratase 1 combats obesity and related metabolic disorders by promoting adipose tissue browning.
Ech1 protects against high-fat-diet-induced hepatic steatosis and insulin resistance.
Title: Enoyl coenzyme A hydratase 1 protects against high-fat-diet-induced hepatic steatosis and insulin resistance.
current work indicates the involvement of Ech1 in tumor metastasis development and progression, but the subcellular location of Ech1 has not much contribution to that.
Title: Ech1 is a potent suppressor of lymphatic metastasis in hepatocarcinoma.
Down-regulation of Ech1 can inhibit the adhesive capacity of metastatic Hca-F cells.
Title: [Down-regulation of Ech1 decreases the adhesion ability of mouse hepatocarcinoma Hca-F cells].
Down-regulation of ECH1 could inhibit the cell proliferation and migration of Hca-F hepatocarcinoma cells.
Title: [Expression of enoyl CoA hydratase 1 reduces cell proliferation and migration in mouse hepatocarcinoma cells].
The downregulation of Ech1 inhibited proliferation of the Hca-F cells, increased the ratio of Hca-F cells in S phase to G(1) phase and decreased the adhesion and migration capacities of Hca-F cells.
Title: Enoyl coenzyme A hydratase 1 is an important factor in the lymphatic metastasis of tumors.
disruption of peroxisomal fatty acid beta-oxidation at the level of enoyl-CoA hydratase/L-3-hydroxyacyl-CoA dehydrogenase (L-PBE) in mice leads to the induction of many of the PPARalpha target genes independently of peroxisome proliferation in hepatocytes
Title: Overexpression of peroxisome proliferator-activated receptor-alpha (PPARalpha)-regulated genes in liver in the absence of peroxisome proliferation in mice deficient in both L- and D-forms of enoyl-CoA hydratase/dehydrogenase enzymes of peroxisomal beta-oxidation system.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124256 (e-PCR)
- UniSTS:161078

AI102822 (e-PCR)
- UniSTS:250550

Ech1 (e-PCR), detects polymorphism
- UniSTS:527322

AI788996 (e-PCR)
- UniSTS:208099

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in peroxisome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

Names: dienoyl-CoA isomerase; peroxisomal/mitochondrial dienoyl-CoA isomerase

NP_058052.1

EC 5.3.3.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016772.1 → NP_058052.1 delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial precursor

See identical proteins and their annotated locations for NP_058052.1

Status: PROVISIONAL

Source sequence(s)

AF030343

Consensus CDS

CCDS21057.1

UniProtKB/Swiss-Prot

O35459, Q5M8P6

Related

ENSMUSP00000066092.7, ENSMUST00000066264.13

Conserved Domains (1) summary

cl23717
Location:53 → 317

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...