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Ctps1 cytidine 5'-triphosphate synthase 1 [ Mus musculus (house mouse) ]

Gene ID: 51797, updated on 11-Apr-2024

Summary

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Official Symbol
Ctps1provided by MGI
Official Full Name
cytidine 5'-triphosphate synthase 1provided by MGI
Primary source
MGI:MGI:1858304
See related
Ensembl:ENSMUSG00000028633 AllianceGenome:MGI:1858304
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ctps
Summary
Predicted to enable CTP synthase activity and identical protein binding activity. Predicted to be involved in lymphocyte proliferation and pyrimidine-containing compound biosynthetic process. Predicted to act upstream of or within glutamine metabolic process and immune system process. Predicted to be active in cytoophidium and cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and respiratory system. Human ortholog(s) of this gene implicated in immunodeficiency 24. Orthologous to human CTPS1 (CTP synthase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 19.6), bladder adult (RPKM 15.5) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D2.1; 4 56.52 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (120397065..120427473, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (120539868..120570276, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene sex comb on midleg homolog 1 Neighboring gene STARR-seq mESC enhancer starr_11247 Neighboring gene STARR-seq mESC enhancer starr_11248 Neighboring gene STARR-seq mESC enhancer starr_11249 Neighboring gene schlafen like 1 Neighboring gene predicted gene 8439 Neighboring gene STARR-seq mESC enhancer starr_11251 Neighboring gene predicted gene, 29891

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CTP synthase 1, a smooth muscle-sensitive therapeutic target for effective vascular repair. Tang R, et al. Arterioscler Thromb Vasc Biol, 2013 Oct. PMID 24008161, Free PMC Article
  2. Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway. Balzarini J, et al. J Biol Chem, 2012 Aug 31. PMID 22730407, Free PMC Article
  3. CTPS and IMPDH form cytoophidia in developmental thymocytes. Peng M, et al. Exp Cell Res, 2021 Aug 1. PMID 34022203
  4. The tumour suppressor PTEN mediates a negative regulation of the E3 ubiquitin-protein ligase Nedd4. Ahn Y, et al. Biochem J, 2008 Jun 1. PMID 18307411
  5. Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain. Lee Y, et al. Biochem Biophys Res Commun, 2020 Aug 13. PMID 32560809

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CTPS1 inhibition selectively blocks smooth muscle cell proliferation without disturbing or even promoting re-endothelialization for effective vascular repair after injury.
    Title: CTP synthase 1, a smooth muscle-sensitive therapeutic target for effective vascular repair.
  2. Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway.
    Title: Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables CTP synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables CTP synthase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in B cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in CTP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in CTP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within glutamine metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in pyrimidine nucleobase biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within pyrimidine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pyrimidine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoophidium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoophidium ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
CTP synthase 1
Names
CTP synthetase 1
UTP--ammonia ligase 1
NP_001342420.1
NP_058028.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355491.1 → NP_001342420.1  CTP synthase 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK148259, AK161110, AL611924, CD363725
    Consensus CDS
    CCDS18591.1
    UniProtKB/Swiss-Prot
    P70698, Q922Y4
    Conserved Domains (1) summary
    PLN02327
    Location:1 → 556
    PLN02327; CTP synthase

  2. NM_016748.2 → NP_058028.2  CTP synthase 1

    See identical proteins and their annotated locations for NP_058028.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant represents the shorter transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK146476, AK148259, AK161110, CD363725
    Consensus CDS
    CCDS18591.1
    UniProtKB/Swiss-Prot
    P70698, Q922Y4
    Related
    ENSMUSP00000030381.8, ENSMUST00000030381.8
    Conserved Domains (1) summary
    PLN02327
    Location:1 → 556
    PLN02327; CTP synthase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    120397065..120427473 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70698.2 GenPept UniProtKB/Swiss-Prot:P70698

Gene LinkOut

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