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MRPS33 mitochondrial ribosomal protein S33 [ Homo sapiens (human) ]

Gene ID: 51650, updated on 5-Mar-2024

Summary

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Official Symbol
MRPS33provided by HGNC
Official Full Name
mitochondrial ribosomal protein S33provided by HGNC
Primary source
HGNC:HGNC:16634
See related
Ensembl:ENSG00000090263 MIM:611993; AllianceGenome:HGNC:16634
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
mS33; S33mt; PTD003; CGI-139; MRP-S33
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. The 28S subunit of the mammalian mitoribosome may play a crucial and characteristic role in translation initiation. This gene encodes a 28S subunit protein that is one of the more highly conserved mitochondrial ribosomal proteins among mammals, Drosophila and C. elegans. Splice variants that differ in the 5' UTR have been found for this gene; all variants encode the same protein. Pseudogenes corresponding to this gene are found on chromosomes 1q, 4p, 4q, and 20q [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in colon (RPKM 28.8), kidney (RPKM 25.5) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See MRPS33 in Genome Data Viewer
Location:
7q34
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (141002610..141014952, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (142316786..142329141, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (140702410..140714752, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375536 Neighboring gene uncharacterized LOC107986720 Neighboring gene chaperonin containing TCP1 subunit 4 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26785 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:140714403-140715048 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26787 Neighboring gene MPRA-validated peak6793 silencer Neighboring gene uncharacterized LOC107986719 Neighboring gene RNA, U4 small nuclear 74, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Distinct class of putative "non-conserved" promoters in humans: comparative studies of alternative promoters of human and mouse genes. Tsuritani K, et al. Genome Res, 2007 Jul. PMID 17567985, Free PMC Article
  2. Ribosome. The structure of the human mitochondrial ribosome. Amunts A, et al. Science, 2015 Apr 3. PMID 25838379, Free PMC Article
  3. The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present. Cavdar Koc E, et al. J Biol Chem, 2001 Jun 1. PMID 11279123
  4. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. Lai CH, et al. Genome Res, 2000 May. PMID 10810093, Free PMC Article
  5. Structure and Function of the Mitochondrial Ribosome. Greber BJ, et al. Annu Rev Biochem, 2016 Jun 2. PMID 27023846

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ21123

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables structural constituent of ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
  
part_of mitochondrial small ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
small ribosomal subunit protein mS33
Names
28S ribosomal protein S33, mitochondrial
mitochondrial small ribosomal subunit protein mS33

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016071.4 → NP_057155.1  small ribosomal subunit protein mS33

    See identical proteins and their annotated locations for NP_057155.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA743808, AC006006, AF151897, AI305281, AK024776, BP870829, W95986
    Consensus CDS
    CCDS5864.1
    UniProtKB/Swiss-Prot
    Q9Y291
    UniProtKB/TrEMBL
    A4D1T3, Q3KRB4
    Related
    ENSP00000376732.3, ENST00000393008.7
    Conserved Domains (1) summary
    pfam08293
    Location:6 → 91
    MRP-S33; Mitochondrial ribosomal subunit S27

  2. NM_053035.3 → NP_444263.1  small ribosomal subunit protein mS33

    See identical proteins and their annotated locations for NP_444263.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses a different segment for its 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA743808, AC006006, AI305281, BC105793, BQ420818, W95986
    Consensus CDS
    CCDS5864.1
    UniProtKB/Swiss-Prot
    Q9Y291
    UniProtKB/TrEMBL
    A4D1T3, Q3KRB4
    Related
    ENSP00000320567.5, ENST00000324787.10
    Conserved Domains (1) summary
    pfam08293
    Location:6 → 91
    MRP-S33; Mitochondrial ribosomal subunit S27

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    141002610..141014952 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    142316786..142329141 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y291.1 GenPept UniProtKB/Swiss-Prot:Q9Y291

Gene LinkOut

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