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ZNF107 zinc finger protein 107 [ Homo sapiens (human) ]

Gene ID: 51427, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF107provided by HGNC
Official Full Name
zinc finger protein 107provided by HGNC
Primary source
HGNC:HGNC:12887
See related
Ensembl:ENSG00000196247 MIM:603989; AllianceGenome:HGNC:12887
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Y8; ZFD25; ZNF588; smap-7
Summary
This gene encodes a protein containing multiple C2H2-type zinc finger regions. Proteins containing zinc fingers may act as transcriptional regulators, but may also have other cellular functions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Expression
Broad expression in lymph node (RPKM 5.5), appendix (RPKM 3.8) and 23 other tissues See more
Orthologs
all
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Genomic context

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Location:
7q11.21
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (64666133..64711577)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (65866222..65919062)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (64126511..64171955)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100128885 Neighboring gene BNIP3 pseudogene 44 Neighboring gene uncharacterized LOC124901656 Neighboring gene uncharacterized LOC105375326 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26060 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26061 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26062 Neighboring gene BCL2 interacting protein 3 pseudogene 11 Neighboring gene microRNA 6839 Neighboring gene myelin protein zero like 1 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26063 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:64254846-64255406 Neighboring gene zinc finger protein 138 Neighboring gene CRISPRi-validated cis-regulatory element chr7.2319 Neighboring gene selenophosphate synthetase 1 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of a novel human gene encoding a zinc finger protein with 25 fingers. Li XA, et al. Biochim Biophys Acta, 1999 Dec 23. PMID 10673043
  2. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. Bellefroid EJ, et al. EMBO J, 1993 Apr. PMID 8467795, Free PMC Article
  3. ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold. Yang W, et al. Theranostics, 2022. PMID 36168627, Free PMC Article
  4. The DNA sequence of human chromosome 7. Hillier LW, et al. Nature, 2003 Jul 10. PMID 12853948
  5. Functional proteomics mapping of a human signaling pathway. Colland F, et al. Genome Res, 2004 Jul. PMID 15231748, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 107
Names
C2H2 type zinc-finger protein
zinc finger protein (ZFD25)
zinc finger protein 588

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013746.3 → NP_001013768.1  zinc finger protein 107 isoform a

    See identical proteins and their annotated locations for NP_001013768.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate exons in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC091799, BC047243, DA723595
    Consensus CDS
    CCDS5527.1
    UniProtKB/Swiss-Prot
    Q9UII5
    Related
    ENSP00000343443.3, ENST00000344930.7
    Conserved Domains (3) summary
    COG5048
    Location:186 → 655
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:414 → 434
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:454 → 479
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001282359.2 → NP_001269288.1  zinc finger protein 107 isoform b

    See identical proteins and their annotated locations for NP_001269288.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks three alternate exons and initiates translation at an alternate upstream start codon, compared to variant 1. The encoded isoform (b) has a longer N-terminus, compared to isoform a.
    Source sequence(s)
    AC091799, DA723595
    Consensus CDS
    CCDS75605.1
    UniProtKB/TrEMBL
    A0A0B4J2G0
    Related
    ENSP00000483720.1, ENST00000620827.6
    Conserved Domains (5) summary
    smart00349
    Location:4 → 64
    KRAB; krueppel associated box
    COG5048
    Location:255 → 724
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:483 → 503
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 43
    KRAB; KRAB box
    pfam13465
    Location:523 → 548
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001282360.2 → NP_001269289.1  zinc finger protein 107 isoform c

    See identical proteins and their annotated locations for NP_001269289.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks four alternate exons and initiates translation at an alternate upstream start codon, compared to variant 1. The encoded isoform (c) is longer and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AC016769, AC091799
    Consensus CDS
    CCDS75606.1
    UniProtKB/TrEMBL
    A0A087WYK5
    Related
    ENSP00000481898.1, ENST00000613690.5
    Conserved Domains (5) summary
    smart00349
    Location:4 → 43
    KRAB; krueppel associated box
    COG5048
    Location:223 → 692
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:451 → 471
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 43
    KRAB; KRAB box
    pfam13465
    Location:491 → 516
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001388025.1 → NP_001374954.1  zinc finger protein 107 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC016769, AC091799
    Conserved Domains (3) summary
    smart00349
    Location:48 → 108
    KRAB; krueppel associated box
    COG5048
    Location:551 → 863
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:527 → 547
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. NM_001388026.1 → NP_001374955.1  zinc finger protein 107 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC016769, AC091799
    Conserved Domains (3) summary
    smart00349
    Location:9 → 69
    KRAB; krueppel associated box
    COG5048
    Location:512 → 824
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:488 → 508
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. NM_016220.5 → NP_057304.1  zinc finger protein 107 isoform a

    See identical proteins and their annotated locations for NP_057304.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC091799, BC017809, BC047243
    Consensus CDS
    CCDS5527.1
    UniProtKB/Swiss-Prot
    Q9UII5
    Related
    ENSP00000400037.1, ENST00000423627.6
    Conserved Domains (3) summary
    COG5048
    Location:186 → 655
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:414 → 434
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:454 → 479
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_104148.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks multiple 3' exons and contains an alternate 3' exon, compared to variant 1. This variant is represented as non-coding because it lacks the entire coding region found in variant 1.
    Source sequence(s)
    AC016769

  2. NR_104149.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks multiple exons and contains an alternate 3' exon, compared to variant 1. This variant is represented as non-coding because it lacks the entire coding region found in variant 1.
    Source sequence(s)
    AC016769

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    64666133..64711577
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420452.1 → XP_047276408.1  zinc finger protein 107 isoform X1

    UniProtKB/Swiss-Prot
    Q9UII5

  2. XM_017012286.2 → XP_016867775.1  zinc finger protein 107 isoform X1

    UniProtKB/Swiss-Prot
    Q9UII5
    Conserved Domains (3) summary
    COG5048
    Location:186 → 655
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:414 → 434
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:454 → 479
    zf-H2C2_2; Zinc-finger double domain

  3. XM_047420451.1 → XP_047276407.1  zinc finger protein 107 isoform X1

    UniProtKB/Swiss-Prot
    Q9UII5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    65866222..65919062
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358348.1 → XP_054214323.1  zinc finger protein 107 isoform X2

    UniProtKB/TrEMBL
    A0A0B4J2G0

  2. XM_054358350.1 → XP_054214325.1  zinc finger protein 107 isoform X1

    UniProtKB/Swiss-Prot
    Q9UII5

  3. XM_054358349.1 → XP_054214324.1  zinc finger protein 107 isoform X1

    UniProtKB/Swiss-Prot
    Q9UII5

  4. XM_054358351.1 → XP_054214326.1  zinc finger protein 107 isoform X1

    UniProtKB/Swiss-Prot
    Q9UII5

  5. XM_054358354.1 → XP_054214329.1  zinc finger protein 107 isoform X1

    UniProtKB/Swiss-Prot
    Q9UII5

  6. XM_054358353.1 → XP_054214328.1  zinc finger protein 107 isoform X1

    UniProtKB/Swiss-Prot
    Q9UII5

  7. XM_054358352.1 → XP_054214327.1  zinc finger protein 107 isoform X1

    UniProtKB/Swiss-Prot
    Q9UII5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UII5.1 GenPept UniProtKB/Swiss-Prot:Q9UII5

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