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EIF3L eukaryotic translation initiation factor 3 subunit L [ Homo sapiens (human) ]

Gene ID: 51386, updated on 3-Apr-2024

Summary

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Official Symbol
EIF3Lprovided by HGNC
Official Full Name
eukaryotic translation initiation factor 3 subunit Lprovided by HGNC
Primary source
HGNC:HGNC:18138
See related
Ensembl:ENSG00000100129 MIM:619197; AllianceGenome:HGNC:18138
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EIF3EIP; EIF3S11; HSPC021; HSPC025; MSTP005; EIF3S6IP
Summary
Enables RNA binding activity. Contributes to translation initiation factor activity. Involved in translational initiation and viral translational termination-reinitiation. Located in membrane. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 248.8), thyroid (RPKM 164.0) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
22q13.1
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (37849419..37889407)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (38311024..38351034)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (38245426..38285414)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 54 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13702 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38244545-38245067 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38245068-38245590 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38245591-38246112 Neighboring gene Sharpr-MPRA regulatory region 5684 Neighboring gene microRNA 658 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38252750-38253250 Neighboring gene microRNA 659 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38253251-38253751 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38258557-38259056 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:38276085-38276244 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38290604-38291248 Neighboring gene RNA, U6 small nuclear 900, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38294770-38295536 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38300995-38301810 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38301811-38302626 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38302627-38303442 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38303443-38304256 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38306246-38307039 Neighboring gene MICAL like 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38313076-38313576 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:38313949-38314111 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38314373-38314874 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38314875-38315374 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38329039-38329841 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38329842-38330643

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The eukaryotic translation initiation factor 3 subunit L protein interacts with Flavivirus NS5 and may modulate yellow fever virus replication. Morais ATs, et al. Virol J, 2013 Jun 22. PMID 23800076, Free PMC Article
  2. Adapted formaldehyde gradient cross-linking protocol implicates human eIF3d and eIF3c, k and l subunits in the 43S and 48S pre-initiation complex assembly, respectively. Herrmannová A, et al. Nucleic Acids Res, 2020 Feb 28. PMID 31863585, Free PMC Article
  3. The human protein HSPC021 interacts with Int-6 and is associated with eukaryotic translation initiation factor 3. Morris-Desbois C, et al. J Biol Chem, 2001 Dec 7. PMID 11590142
  4. Subunit architecture of multiprotein assemblies determined using restraints from gas-phase measurements. Pukala TL, et al. Structure, 2009 Sep 9. PMID 19748344
  5. Ubiquitin-specific protease 2a promotes hepatocellular carcinoma progression via deubiquitination and stabilization of RAB1A. Xiong B, et al. Cell Oncol (Dordr), 2021 Apr. PMID 33074477

See all (167) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Whereas the eIF3c knockdown reduces it, downregulation of eIF3k or eIF3l increases mRNA recruitment, suggesting that the latter subunits possess a regulatory potential. Altogether this study provides new insights into the role of human eIF3 in the initial assembly steps of the translational machinery
    Title: Adapted formaldehyde gradient cross-linking protocol implicates human eIF3d and eIF3c, k and l subunits in the 43S and 48S pre-initiation complex assembly, respectively.
  2. These results indicate an interaction of human eIF3L with yellow fever virus NS5 and that eIF3L overexpression facilitates translation, which has potential implications for virus replication.
    Title: The eukaryotic translation initiation factor 3 subunit L protein interacts with Flavivirus NS5 and may modulate yellow fever virus replication.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Pol gag-pol HIV-1 Pol is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit L (EIF3L) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit L (EIF3L) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to translation initiation factor activity IC
Inferred by Curator
more info
 PubMed 
contributes_to translation initiation factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in formation of cytoplasmic translation initiation complex NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational initiation IC
Inferred by Curator
more info
 PubMed 
involved_in translational initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in viral translational termination-reinitiation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of eukaryotic 43S preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic 48S preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 3 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 3 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of eukaryotic translation initiation factor 3 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in fibrillar center IEA
Inferred from Electronic Annotation
more info
  
located_in membrane HDA PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
eukaryotic translation initiation factor 3 subunit L
Names
eIEF associated protein HSPC021
eukaryotic translation initiation factor 3 subunit 6-interacting protein
eukaryotic translation initiation factor 3 subunit E-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242923.2 → NP_001229852.1  eukaryotic translation initiation factor 3 subunit L isoform 2

    See identical proteins and their annotated locations for NP_001229852.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two consecutive exons in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK302346, AL022311, CD638692, DA663575, Z97630
    Consensus CDS
    CCDS56230.1
    UniProtKB/TrEMBL
    B4DQF6
    Related
    ENSP00000371099.4, ENST00000381683.10
    Conserved Domains (1) summary
    pfam10255
    Location:146 → 502
    Paf67; RNA polymerase I-associated factor PAF67

  2. NM_001363785.2 → NP_001350714.1  eukaryotic translation initiation factor 3 subunit L isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL022311, BC029265, DA947257
    Consensus CDS
    CCDS87024.1
    UniProtKB/TrEMBL
    A0A024R1K4, B0QY90
    Related
    ENSP00000384634.1, ENST00000406934.5
    Conserved Domains (1) summary
    pfam10255
    Location:54 → 452
    Paf67; RNA polymerase I-associated factor PAF67

  3. NM_016091.4 → NP_057175.1  eukaryotic translation initiation factor 3 subunit L isoform 1

    See identical proteins and their annotated locations for NP_057175.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL022311, BC029265, DA051005
    Consensus CDS
    CCDS13960.1
    UniProtKB/Swiss-Prot
    B2RDG6, B4DYB2, G8JLH4, Q53HQ1, Q53HT4, Q5QTR1, Q5TI15, Q6ICD2, Q9Y262
    UniProtKB/TrEMBL
    B4DQF6
    Related
    ENSP00000499067.1, ENST00000652021.1
    Conserved Domains (1) summary
    pfam10255
    Location:152 → 550
    Paf67; RNA polymerase I-associated factor PAF67

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    37849419..37889407
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006724260.5 → XP_006724323.2  eukaryotic translation initiation factor 3 subunit L isoform X1

  2. XM_047441389.1 → XP_047297345.1  eukaryotic translation initiation factor 3 subunit L isoform X2

    UniProtKB/TrEMBL
    A0A024R1K4, B0QY90

  3. XM_047441390.1 → XP_047297346.1  eukaryotic translation initiation factor 3 subunit L isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    38311024..38351034
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054325671.1 → XP_054181646.1  eukaryotic translation initiation factor 3 subunit L isoform X1

  2. XM_054325672.1 → XP_054181647.1  eukaryotic translation initiation factor 3 subunit L isoform X2

    UniProtKB/TrEMBL
    A0A024R1K4, B0QY90

  3. XM_054325673.1 → XP_054181648.1  eukaryotic translation initiation factor 3 subunit L isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y262.1 GenPept UniProtKB/Swiss-Prot:Q9Y262

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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