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CLEC1B C-type lectin domain family 1 member B [ Homo sapiens (human) ]

Gene ID: 51266, updated on 16-Apr-2024

Summary

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Official Symbol
CLEC1Bprovided by HGNC
Official Full Name
C-type lectin domain family 1 member Bprovided by HGNC
Primary source
HGNC:HGNC:24356
See related
Ensembl:ENSG00000165682 MIM:606783; AllianceGenome:HGNC:24356
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLEC2; CLEC2B; PRO1384; QDED721; 1810061I13Rik
Summary
Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan 2011]
Expression
Biased expression in liver (RPKM 4.2), bone marrow (RPKM 0.6) and 1 other tissue See more
Orthologs
mouse all
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Genomic context

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Location:
12p13.31-p13.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (9993075..10001899, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (9879239..9888052, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (10145674..10154498, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2470 Neighboring gene CLEC12A antisense RNA 1 Neighboring gene uncharacterized LOC124902874 Neighboring gene C-type lectin domain family 12 member A Neighboring gene uncharacterized LOC102724020 Neighboring gene C-type lectin domain family 12 member B Neighboring gene C-type lectin domain family 1 member B pseudogene Neighboring gene C-type lectin domain containing 9A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. [Expression of Clec2 in Patients with Myelodysplastic Syndrome and Its Correlation with TPO]. Jin JC, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2020 Oct. PMID 33067967
  2. Control of Platelet CLEC-2-Mediated Activation by Receptor Clustering and Tyrosine Kinase Signaling. Martyanov AA, et al. Biophys J, 2020 Jun 2. PMID 32396849, Free PMC Article
  3. High CLEC-2 expression associates with unfavorable postoperative prognosis of patients with clear cell renal cell carcinoma. Xiong Y, et al. Oncotarget, 2016 Sep 27. PMID 27564117, Free PMC Article
  4. C-Type Lectin-Like Receptor 2 Suppresses AKT Signaling and Invasive Activities of Gastric Cancer Cells by Blocking Expression of Phosphoinositide 3-Kinase Subunits. Wang L, et al. Gastroenterology, 2016 May. PMID 26855187
  5. A detailed proteomic analysis of rhodocytin-activated platelets reveals novel clues on the CLEC-2 signalosome: implications for CLEC-2 signaling regulation. Parguiña AF, et al. Blood, 2012 Dec 20. PMID 23053573

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Endothelial CLEC-1b plays a protective role against cancer hematogenous metastasis.
    Title: Endothelial CLEC-1b plays a protective role against cancer hematogenous metastasis.
  2. Heme induces human and mouse platelet activation through C-type-lectin-like receptor-2.
    Title: Heme induces human and mouse platelet activation through C-type-lectin-like receptor-2.
  3. Control of Platelet CLEC-2-Mediated Activation by Receptor Clustering and Tyrosine Kinase Signaling.
    Title: Control of Platelet CLEC-2-Mediated Activation by Receptor Clustering and Tyrosine Kinase Signaling.
  4. [Expression of Clec2 in Patients with Myelodysplastic Syndrome and Its Correlation with TPO].
    Title: [Expression of Clec2 in Patients with Myelodysplastic Syndrome and Its Correlation with TPO].
  5. Platelet membrane lipid rafts protein composition varies following GPVI and CLEC-2 receptors activation.
    Title: Platelet membrane lipid rafts protein composition varies following GPVI and CLEC-2 receptors activation.
  6. Platelets and cancer-associated thrombosis: focusing on the platelet activation receptor CLEC-2 and podoplanin.
    Title: Platelets and cancer-associated thrombosis: focusing on the platelet activation receptor CLEC-2 and podoplanin.
  7. Functional significance of the platelet immune receptors GPVI and CLEC-2.
    Title: Functional significance of the platelet immune receptors GPVI and CLEC-2.
  8. tetraspanin CD37 controls CLEC-2 membrane organization and provides new molecular insights into the mechanisms underlying CLEC-2-dependent dendritic cell migration.
    Title: C-type lectin-like receptor 2 (CLEC-2)-dependent dendritic cell migration is controlled by tetraspanin CD37.
  9. CLEC-2 may have a role in unfavorable postoperative prognosis of patients with clear cell renal cell carcinoma
    Title: High CLEC-2 expression associates with unfavorable postoperative prognosis of patients with clear cell renal cell carcinoma.
  10. CLEC-2 and P2Y12 are required for CpG ODN-induced platelet activation and thrombosis, and might be targeted to prevent adverse events in patients at risk.
    Title: Targeting of C-type lectin-like receptor 2 or P2Y12 for the prevention of platelet activation by immunotherapeutic CpG oligodeoxynucleotides.
Submit: New GeneRIF Correction See all GeneRIFs (41)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane signaling receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in defense response TAS
Traceable Author Statement
more info
 PubMed 
involved_in platelet formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
C-type lectin domain family 1 member B
Names
C-type lectin-like receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099431.2 → NP_001092901.1  C-type lectin domain family 1 member B isoform b

    See identical proteins and their annotated locations for NP_001092901.1

    Status: VALIDATED

    Source sequence(s)
    AC091814
    Consensus CDS
    CCDS41751.1
    UniProtKB/Swiss-Prot
    Q9P126
    Related
    ENSP00000327169.6, ENST00000348658.4
    Conserved Domains (1) summary
    cd03593
    Location:69 → 185
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

  2. NM_001393342.1 → NP_001380271.1  C-type lectin domain family 1 member B isoform a

    Status: VALIDATED

    Source sequence(s)
    AC091814
    Consensus CDS
    CCDS41752.1
    UniProtKB/Swiss-Prot
    Q6UWX7, Q8NHR6, Q9P126
    Conserved Domains (1) summary
    cd03593
    Location:102 → 218
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

  3. NM_016509.4 → NP_057593.3  C-type lectin domain family 1 member B isoform a

    See identical proteins and their annotated locations for NP_057593.3

    Status: VALIDATED

    Source sequence(s)
    AC091814
    Consensus CDS
    CCDS41752.1
    UniProtKB/Swiss-Prot
    Q6UWX7, Q8NHR6, Q9P126
    Related
    ENSP00000298527.6, ENST00000298527.11
    Conserved Domains (1) summary
    cd03593
    Location:102 → 218
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    9993075..10001899 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047428938.1 → XP_047284894.1  C-type lectin domain family 1 member B isoform X1

    UniProtKB/Swiss-Prot
    Q6UWX7, Q8NHR6, Q9P126

  2. XM_011520685.3 → XP_011518987.1  C-type lectin domain family 1 member B isoform X2

    See identical proteins and their annotated locations for XP_011518987.1

    UniProtKB/Swiss-Prot
    Q9P126
    Conserved Domains (1) summary
    cd03593
    Location:69 → 185
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    9879239..9888052 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054372190.1 → XP_054228165.1  C-type lectin domain family 1 member B isoform X1

  2. XM_054372191.1 → XP_054228166.1  C-type lectin domain family 1 member B isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9P126.2 GenPept UniProtKB/Swiss-Prot:Q9P126

Gene LinkOut

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