Rgs1 regulator of G-protein signaling 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rgs1provided by MGI
Official Full Name: regulator of G-protein signaling 1provided by MGI
Primary source: MGI:MGI:1354694
See related: Ensembl:ENSMUSG00000026358 AllianceGenome:MGI:1354694
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BL34
Summary: Predicted to enable G-protein alpha-subunit binding activity and GTPase activator activity. Acts upstream of or within response to bacterium. Predicted to be located in cytosol. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Orthologous to human RGS1 (regulator of G protein signaling 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in bladder adult (RPKM 2.1), liver E18 (RPKM 0.7) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 F; 1 62.56 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (144120407..144124862, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (144244669..144249104, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RGS1 mediates renal interstitial fibrosis through activation of the inflammatory response.
Title: RGS1 mediates renal interstitial fibrosis through activation of the inflammatory response.
Regulator of G-protein signaling 1 critically supports CD8[+] TRM cell-mediated intestinal immunity.
Title: Regulator of G-protein signaling 1 critically supports CD8(+) T(RM) cell-mediated intestinal immunity.
Inhibiting RGS1 attenuates secondary inflammation response and tissue degradation via the TLR/TRIF/NF-kappaB pathway in macrophage post spinal cord injury.
Title: Inhibiting RGS1 attenuates secondary inflammation response and tissue degradation via the TLR/TRIF/NF-κB pathway in macrophage post spinal cord injury.
Erk1/2 signalling and calcium influx are major effectors of Rgs1-mediated vascular contractile responses.
Title: Vascular wall regulator of G-protein signalling-1 (RGS-1) is required for angiotensin II-mediated blood pressure control.
Rgs1 knockdown increased the size of germinal centers, but decreased the frequency of T follicular helper cells.
Title: The autoimmunity-associated gene RGS1 affects the frequency of T follicular helper cells.
Rgs1 has a role in leukocyte trafficking and vascular inflammation
Title: RGS1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signalling.
Variations in Gnai2 and Rgs1 expression affect chemokine receptor signaling and the organization of secondary lymphoid organs.
Title: Variations in Gnai2 and Rgs1 expression affect chemokine receptor signaling and the organization of secondary lymphoid organs.
RGS1 can modulate the expression of costimulatory molecules and cytokine secretion, and interrupt Toll like receptor signal pathways, which suggest that RGS1 may play a role in regulating immune responses.
Title: [RGS1 is involved in the regulation of co-stimulatory molecules and cytokines in RAW264.7 cells].
Rgs1(-/-) mice possess B cells that respond excessively and desensitize improperly to the chemokines CXCL12 and CXCL13. Many of the B-cell follicles in the spleens of Rgs1(-/-) mice have germinal centers even in the absence of immune stimulation.
Title: Abnormal B-cell responses to chemokines, disturbed plasma cell localization, and distorted immune tissue architecture in Rgs1-/- mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G-protein alpha-subunit binding	ISO Inferred from Sequence Orthology more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables GTPase activator activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in leukotriene signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: regulator of G-protein signaling 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_015811.2 → NP_056626.2 regulator of G-protein signaling 1

See identical proteins and their annotated locations for NP_056626.2

Status: VALIDATED

Source sequence(s)

AF215667, AK138688, BU695313

Consensus CDS

CCDS15349.2

UniProtKB/Swiss-Prot

Q3TBD1, Q3TC18, Q3TD56, Q3U477, Q9JL25

Related

ENSMUSP00000140624.2, ENSMUST00000189061.7

Conserved Domains (1) summary

cl02565
Location:86 → 199

RGS; Regulator of G protein signaling (RGS) domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

144120407..144124862 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036152293.1 → XP_036008186.1 regulator of G-protein signaling 1 isoform X1

Conserved Domains (1) summary

cl02565
Location:86 → 198

RGS; Regulator of G protein signaling (RGS) domain superfamily