U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mapk6 mitogen-activated protein kinase 6 [ Mus musculus (house mouse) ]

Gene ID: 50772, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Mapk6provided by MGI
Official Full Name
mitogen-activated protein kinase 6provided by MGI
Primary source
MGI:MGI:1354946
See related
Ensembl:ENSMUSG00000042688 AllianceGenome:MGI:1354946
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Erk3; Mapk4; Prkm4; Prkm6; Mapk63; 2610021I23Rik; D130053K17Rik
Summary
Enables MAP kinase activity; protein heterodimerization activity; and protein kinase binding activity. Involved in protein phosphorylation. Acts upstream of or within positive regulation of dendritic spine development. Located in cytoplasm; nucleus; and septin cytoskeleton. Part of protein-containing complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human MAPK6 (mitogen-activated protein kinase 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 62.3), CNS E11.5 (RPKM 31.4) and 25 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
9 D; 9 42.3 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (75294064..75317303, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (75386782..75410016, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24661 Neighboring gene zygote arrest 1-like pseudogene Neighboring gene tubulin, alpha 1A pseudogene Neighboring gene STARR-seq mESC enhancer starr_24662 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:75249977-75250086 Neighboring gene STARR-positive B cell enhancer ABC_E11414 Neighboring gene RIKEN cDNA 4933433G15 gene Neighboring gene STARR-positive B cell enhancer ABC_E3844 Neighboring gene STARR-positive B cell enhancer ABC_E6767 Neighboring gene Leo1, Paf1/RNA polymerase II complex component Neighboring gene STARR-seq mESC enhancer starr_24669 Neighboring gene predicted gene, 57538

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The atypical MAPK ERK3 controls positive selection of thymocytes. Sirois J, et al. Immunology, 2015 May. PMID 25521218, Free PMC Article
  2. Targeting ERK3/MK5 complex for treatment of obesity and diabetes. Loza-Valdes A, et al. Biochem Biophys Res Commun, 2022 Jul 5. PMID 35523049
  3. Circ_0000285 promotes podocyte injury through sponging miR-654-3p and activating MAPK6 in diabetic nephropathy. Yao T, et al. Gene, 2020 Jul 15. PMID 32275999
  4. The adrenergic-induced ERK3 pathway drives lipolysis and suppresses energy dissipation. El-Merahbi R, et al. Genes Dev, 2020 Apr 1. PMID 32139423, Free PMC Article
  5. The catalytic activity of the mitogen-activated protein kinase extracellular signal-regulated kinase 3 is required to sustain CD4+ CD8+ thymocyte survival. Marquis M, et al. Mol Cell Biol, 2014 Sep 15. PMID 25002529, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. circ_0000285 promoted podocyte injury via sponging miR-654-3p and activating MAPK6 in diabetic nephropathy.
    Title: Circ_0000285 promotes podocyte injury through sponging miR-654-3p and activating MAPK6 in diabetic nephropathy.
  2. Results show that Cdo is important for full Abl kinase activity, and Abl is necessary for full activation of p38 MAPK, during myogenic differentiation.
    Title: Cdo binds Abl to promote p38alpha/beta mitogen-activated protein kinase activity and myogenic differentiation.
  3. Data show that extracellular-regulated kinase 3 (ERK3) specifically interacts with the MAPK-activated protein kinase 5 (MK5 or PRAK) in vitro and in vivo.
    Title: Scaffolding by ERK3 regulates MK5 in development.
  4. p38gamma MAP kinase (SAPK3/p38gamma) was shown to catalyse phosphorylation of SAP97.
    Title: p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP.
  5. ERK3 biological activity is regulated by its cellular abundance through the control of protein stability
    Title: Rapid turnover of extracellular signal-regulated kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation.
  6. Results demonstrate a specific interaction between extracellular signal-regulated kinase 3 (ERK3) and mitogen-activated protein kinase-activated protein kinase-5 (MK5).
    Title: Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of dendritic spine development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in septin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
mitogen-activated protein kinase 6
Names
Erk-3 related
MAP kinase 6
extracellular signal-regulated kinase 3
mitogen activated protein kinase 4
protein kinase, mitogen activated kinase 4
NP_056621.4
NP_081694.1
XP_011241069.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015806.5 → NP_056621.4  mitogen-activated protein kinase 6

    See identical proteins and their annotated locations for NP_056621.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC115880, AK051508, BC048779, BC100385, CA325060
    Consensus CDS
    CCDS23342.1
    UniProtKB/Swiss-Prot
    Q497T9, Q61532, Q6YKB0, Q7TT30, Q80XH5, Q922U4, Q9JLU6
    Related
    ENSMUSP00000040315.11, ENSMUST00000049355.11
    Conserved Domains (1) summary
    cd07854
    Location:14 → 355
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

  2. NM_027418.2 → NP_081694.1  mitogen-activated protein kinase 6

    See identical proteins and their annotated locations for NP_081694.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC115880, AK051508, BC048779, BC100385, BY737145
    Consensus CDS
    CCDS23342.1
    UniProtKB/Swiss-Prot
    Q497T9, Q61532, Q6YKB0, Q7TT30, Q80XH5, Q922U4, Q9JLU6
    Related
    ENSMUSP00000129024.2, ENSMUST00000168937.8
    Conserved Domains (1) summary
    cd07854
    Location:14 → 355
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    75294064..75317303 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242767.4 → XP_011241069.1  mitogen-activated protein kinase 6 isoform X1

    See identical proteins and their annotated locations for XP_011241069.1

    UniProtKB/Swiss-Prot
    Q497T9, Q61532, Q6YKB0, Q7TT30, Q80XH5, Q922U4, Q9JLU6
    Conserved Domains (1) summary
    cd07854
    Location:14 → 355
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61532.3 GenPept UniProtKB/Swiss-Prot:Q61532

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous