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Cspg5 chondroitin sulfate proteoglycan 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 50568, updated on 13-Apr-2024

Summary

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Official Symbol
Cspg5provided by RGD
Official Full Name
chondroitin sulfate proteoglycan 5provided by RGD
Primary source
RGD:2431
See related
Ensembl:ENSRNOG00000020833 AllianceGenome:RGD:2431
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ngc; Caleb
Summary
Involved in cytoskeleton organization; neurogenesis; and positive regulation of substrate adhesion-dependent cell spreading. Predicted to be located in Golgi apparatus and Golgi-associated vesicle membrane. Predicted to be active in GABA-ergic synapse and glutamatergic synapse. Predicted to be integral component of postsynaptic membrane. Orthologous to human CSPG5 (chondroitin sulfate proteoglycan 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 449.2) and Adrenal (RPKM 22.6) See more
Orthologs
human mouse all
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Genomic context

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See Cspg5 in Genome Data Viewer
Location:
8q32
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (119098932..119113191)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (110220506..110234766)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (118333695..118348040)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480238 Neighboring gene small nucleolar RNA SNORA43 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 Neighboring gene ribosomal protein S23, pseudogene 11 Neighboring gene elongator acetyltransferase complex subunit 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Repeated cocaine administration alters the expression of genes in corticolimbic circuitry after a 3-week withdrawal: a DNA macroarray study. Toda S, et al. J Neurochem, 2002 Sep. PMID 12358776
  2. Neuroglycan C, a neural tissue-specific transmembrane chondroitin sulfate proteoglycan, in retinal neural network formation. Inatani M, et al. Invest Ophthalmol Vis Sci, 2000 Dec. PMID 11095636
  3. Neuroglycan C, a novel membrane-spanning chondroitin sulfate proteoglycan that is restricted to the brain. Watanabe E, et al. J Biol Chem, 1995 Nov 10. PMID 7592931
  4. Chondroitin sulfate proteoglycan-5 forms perisynaptic matrix assemblies in the adult rat cortex. Pintér A, et al. Cell Signal, 2020 Oct. PMID 32653642
  5. The neural EGF family member CALEB/NGC mediates dendritic tree and spine complexity. Brandt N, et al. EMBO J, 2007 May 2. PMID 17431398, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Chondroitin sulfate proteoglycan-5 forms perisynaptic matrix assemblies in the adult rat cortex.
    Title: Chondroitin sulfate proteoglycan-5 forms perisynaptic matrix assemblies in the adult rat cortex.
  2. Rac1, Cdc42, and RhoG perform very specific and non-redundant functions at different levels of hierarchy in regulating dendritic tree complexity induced by CALEB/NGC
    Title: Different roles of the small GTPases Rac1, Cdc42, and RhoG in CALEB/NGC-induced dendritic tree complexity.
  3. PI3K-Akt-mammalian target of rapamycin (mTOR) signaling pathway and PKC are important for CALEB/NGC-induced stimulation of dendritic branching. CALEB/NGC-induced spine morphogenesis is independent of PI3K but depends on PKC.
    Title: The neural EGF family member CALEB/NGC mediates dendritic tree and spine complexity.
  4. there is a glycosylation site for chondroitin sulfate on the neural part-time proteoglycan, neuroglycan C
    Title: Glycosylation site for chondroitin sulfate on the neural part-time proteoglycan, neuroglycan C.
  5. neuroglycan C is a novel component of midkine receptors involved in process elongation
    Title: Neuroglycan C is a novel midkine receptor involved in process elongation of oligodendroglial precursor-like cells.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in axon regeneration IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cell projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glial cell projection elongation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synaptic vesicle exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of synaptic vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in GABA-ergic synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi-associated vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi-associated vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi-associated vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
chondroitin sulfate proteoglycan 5
Names
acidic leucine-rich EGF-like domain-containing brain protein
neuroglycan C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019284.3 → NP_062157.2  chondroitin sulfate proteoglycan 5 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 3' coding region, compared to variant 2. This results in a shorter protein (isoform 1), compared to isoform 2.
    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    F1M4R7
    Conserved Domains (2) summary
    pfam06566
    Location:34 → 281
    Chon_Sulph_att; Chondroitin sulphate attachment domain
    pfam06567
    Location:452 → 543
    Neural_ProG_Cyt; Neural chondroitin sulphate proteoglycan cytoplasmic domain

  2. NM_133652.2 → NP_598413.1  chondroitin sulfate proteoglycan 5 isoform 2 precursor

    See identical proteins and their annotated locations for NP_598413.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes the longer isoform (2).
    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    Q62831, Q9ERQ6
    UniProtKB/TrEMBL
    F1M4R7
    Related
    ENSRNOP00000028278.8, ENSRNOT00000028278.8
    Conserved Domains (2) summary
    pfam06566
    Location:33 → 278
    Chon_Sulph_att; Chondroitin sulphate attachment domain
    pfam06567
    Location:452 → 570
    Neural_ProG_Cyt; Neural chondroitin sulphate proteoglycan cytoplasmic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    119098932..119113191
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ERQ6.1 GenPept UniProtKB/Swiss-Prot:Q9ERQ6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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