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Lats2 large tumor suppressor 2 [ Mus musculus (house mouse) ]

Gene ID: 50523, updated on 12-May-2024

Summary

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Official Symbol
Lats2provided by MGI
Official Full Name
large tumor suppressor 2provided by MGI
Primary source
MGI:MGI:1354386
See related
Ensembl:ENSMUSG00000021959 Ensembl:ENSMUSG00000114942 AllianceGenome:MGI:1354386
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4932411G09Rik
Summary
Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Involved in G1/S transition of mitotic cell cycle; negative regulation of protein localization to nucleus; and regulation of transforming growth factor beta receptor signaling pathway. Acts upstream of or within several processes, including hippo signaling; inner cell mass cell differentiation; and keratinocyte differentiation. Located in spindle pole. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and immune system. Orthologous to human LATS2 (large tumor suppressor kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 26.6), lung adult (RPKM 25.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 C3; 14 30.28 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (57927119..57983669, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (57689662..57746212, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700039M10 gene Neighboring gene STARR-positive B cell enhancer ABC_E5445 Neighboring gene exportin 4 Neighboring gene STARR-seq mESC enhancer starr_36813 Neighboring gene predicted gene, 26440 Neighboring gene STARR-seq mESC enhancer starr_36814 Neighboring gene predicted gene, 52140 Neighboring gene STARR-seq mESC enhancer starr_36815 Neighboring gene microRNA 3077 Neighboring gene Sin3-associated polypeptide 18 Neighboring gene STARR-positive B cell enhancer ABC_E10829 Neighboring gene spindle and kinetochore associated complex subunit 3 Neighboring gene mitochondrial ribosomal protein L57

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation. Aylon Y, et al. Genes Dev, 2016 Apr 1. PMID 27013235, Free PMC Article
  2. Lats2 is critical for the pluripotency and proper differentiation of stem cells. Aylon Y, et al. Cell Death Differ, 2014 Apr. PMID 24413153, Free PMC Article
  3. Lats2 modulates adipocyte proliferation and differentiation via hippo signaling. An Y, et al. PLoS One, 2013. PMID 23977200, Free PMC Article
  4. Lats2 is an essential mitotic regulator required for the coordination of cell division. Yabuta N, et al. J Biol Chem, 2007 Jun 29. PMID 17478426
  5. Dual transforming activities of the FUS (TLS)-ERG leukemia fusion protein conferred by two N-terminal domains of FUS (TLS). Ichikawa H, et al. Mol Cell Biol, 1999 Nov. PMID 10523652, Free PMC Article

See all (114) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Proximal Tubular Lats2 Ablation Exacerbates Ischemia/Reperfusion Injury (IRI)-Induced Renal Maladaptive Repair through the Upregulation of P53.
    Title: Proximal Tubular Lats2 Ablation Exacerbates Ischemia/Reperfusion Injury (IRI)-Induced Renal Maladaptive Repair through the Upregulation of P53.
  2. Lats2 deficiency protects the heart against myocardial infarction by reducing inflammation and inhibiting mitochondrial fission and STING/p65 signaling.
    Title: Lats2 deficiency protects the heart against myocardial infarction by reducing inflammation and inhibiting mitochondrial fission and STING/p65 signaling.
  3. Targeted Disruption of Lats1 and Lats2 in Mice Impairs Testis Development and Alters Somatic Cell Fate.
    Title: Targeted Disruption of Lats1 and Lats2 in Mice Impairs Testis Development and Alters Somatic Cell Fate.
  4. LATS1/2 control TGFB-directed epithelial-to-mesenchymal transition in the murine dorsal cranial neuroepithelium through YAP regulation.
    Title: LATS1/2 control TGFB-directed epithelial-to-mesenchymal transition in the murine dorsal cranial neuroepithelium through YAP regulation.
  5. Lats2 promotes heart failure by stimulating p53-mediated apoptosis during pressure overload.
    Title: Lats2 promotes heart failure by stimulating p53-mediated apoptosis during pressure overload.
  6. Deletion of Lats1/2 in adult kidney epithelia leads to renal cell carcinoma.
    Title: Deletion of Lats1/2 in adult kidney epithelia leads to renal cell carcinoma.
  7. Inactivation of Lats1 and Lats2 highlights the role of hippo pathway effector YAP in larynx and vocal fold epithelium morphogenesis.
    Title: Inactivation of Lats1 and Lats2 highlights the role of hippo pathway effector YAP in larynx and vocal fold epithelium morphogenesis.
  8. MiR-429 Involves in the Pathogenesis of Colorectal Cancer via Directly Targeting LATS2.
    Title: MiR-429 Involves in the Pathogenesis of Colorectal Cancer via Directly Targeting LATS2.
  9. A single copy of large tumor suppressor 1 or large tumor suppressor 2 is sufficient for normal hematopoiesis.
    Title: A single copy of large tumor suppressor 1 or large tumor suppressor 2 is sufficient for normal hematopoiesis.
  10. The tumor suppressor LATS2 reduces v-Src-induced membrane blebs in a kinase activity-independent manner.
    Title: The tumor suppressor LATS2 reduces v-Src-induced membrane blebs in a kinase activity-independent manner.
Submit: New GeneRIF Correction See all GeneRIFs (33)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (7)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G1/S transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within hippo signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in hippo signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in hormone-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within inner cell mass cell fate commitment IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within inner cell mass cellular morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within keratinocyte differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein localization to nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein localization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein localization IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of organ growth IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of organ growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle pole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase LATS2
Names
kinase phosphorylated during mitosis protein
large tumor suppressor homolog 2
serine/threonine-protein kinase kpm
NP_056586.2
NP_700431.1
XP_006519287.1
XP_006519288.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015771.2 → NP_056586.2  serine/threonine-protein kinase LATS2 isoform 1

    See identical proteins and their annotated locations for NP_056586.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (A) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    BC053028, BU705730
    Consensus CDS
    CCDS27158.1
    UniProtKB/Swiss-Prot
    Q7TSJ6, Q8CDJ4, Q9JMI3
    UniProtKB/TrEMBL
    G3UY78
    Related
    ENSMUSP00000022531.8, ENSMUST00000022531.14
    Conserved Domains (3) summary
    smart00220
    Location:626 → 931
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14398
    Location:100 → 140
    UBA_LATS2; UBA domain found in vertebrate serine/threonine-protein kinase LATS2
    cl21453
    Location:624 → 1004
    PKc_like; Protein Kinases, catalytic domain

  2. NM_153382.1 → NP_700431.1  serine/threonine-protein kinase LATS2 isoform 2

    See identical proteins and their annotated locations for NP_700431.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (B) lacks the first exon, most of the 3' coding region and uses a different terminal exon compared to variant A. The resulting protein (isoform 2, also called LATS2B) is much shorter and has a distinct C-terminus when it is compared to isoform 1.
    Source sequence(s)
    AC154504, BF147719
    Consensus CDS
    CCDS49508.1
    UniProtKB/TrEMBL
    Q8VHE2
    Related
    ENSMUSP00000077130.7, ENSMUST00000077981.7

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    57927119..57983669 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519224.4 → XP_006519287.1  serine/threonine-protein kinase LATS2 isoform X1

    UniProtKB/TrEMBL
    G3UXG3
    Related
    ENSMUSP00000133680.2, ENSMUST00000174694.8
    Conserved Domains (3) summary
    PHA03247
    Location:150 → 513
    PHA03247; large tegument protein UL36; Provisional
    cd14398
    Location:100 → 140
    UBA_LATS2; UBA domain found in vertebrate serine/threonine-protein kinase LATS2
    cl21453
    Location:624 → 847
    PKc_like; Protein Kinases, catalytic domain

  2. XM_006519225.4 → XP_006519288.1  serine/threonine-protein kinase LATS2 isoform X2

    See identical proteins and their annotated locations for XP_006519288.1

    UniProtKB/TrEMBL
    Q8VHE2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TSJ6.1 GenPept UniProtKB/Swiss-Prot:Q7TSJ6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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