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Ebi3 Epstein-Barr virus induced gene 3 [ Mus musculus (house mouse) ]

Gene ID: 50498, updated on 5-Mar-2024

Summary

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Official Symbol
Ebi3provided by MGI
Official Full Name
Epstein-Barr virus induced gene 3provided by MGI
Primary source
MGI:MGI:1354171
See related
Ensembl:ENSMUSG00000003206 AllianceGenome:MGI:1354171
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EBI-3; IL-27
Summary
Enables interleukin-27 receptor binding activity. Involved in T cell proliferation. Predicted to be located in extracellular space and membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including decidua; extraembryonic component; sensory organ; and skeleton. Orthologous to human EBI3 (Epstein-Barr virus induced 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 18.1), mammary gland adult (RPKM 10.2) and 21 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 D; 17 29.08 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (56259623..56264022)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (55952623..55957022)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2495 Neighboring gene zinc finger protein 959 Neighboring gene predicted gene, 41603 Neighboring gene ribosomal protein L21, pseudogene 6 Neighboring gene STARR-seq mESC enhancer starr_42873 Neighboring gene STARR-positive B cell enhancer ABC_E4220 Neighboring gene zinc finger protein 119b Neighboring gene STARR-positive B cell enhancer ABC_E7546 Neighboring gene STARR-positive B cell enhancer ABC_E2496 Neighboring gene predicted gene, 16712 Neighboring gene YJU2 splicing factor Neighboring gene src homology 2 domain-containing transforming protein D

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. IL-35 subunit EBI3 alleviates bleomycin-induced pulmonary fibrosis via suppressing DNA enrichment of STAT3. Chen D, et al. Respir Res, 2021 Oct 28. PMID 34711217, Free PMC Article
  2. Interleukin 27 Protects From Gastric Atrophy and Metaplasia During Chronic Autoimmune Gastritis. Bockerstett KA, et al. Cell Mol Gastroenterol Hepatol, 2020. PMID 32376420, Free PMC Article
  3. Epigenetic and parasitological parameters are modulated in EBi3-/- mice infected with Schistosoma mansoni. Mota EA, et al. PLoS Negl Trop Dis, 2020 Feb. PMID 32078636, Free PMC Article
  4. Ebi3 promotes T- and B-cell division and differentiation via STAT3. Ma N, et al. Mol Immunol, 2019 Mar. PMID 30660991
  5. EBI3 regulates the NK cell response to mouse cytomegalovirus infection. Jensen H, et al. Proc Natl Acad Sci U S A, 2017 Feb 14. PMID 28143936, Free PMC Article

See all (105) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ebi3 knockout aggravates experimental periodontitis via Th17 polarization.
    Title: Ebi3 knockout aggravates experimental periodontitis via Th17 polarization.
  2. IL-35 subunit EBI3 alleviates bleomycin-induced pulmonary fibrosis via suppressing DNA enrichment of STAT3.
    Title: IL-35 subunit EBI3 alleviates bleomycin-induced pulmonary fibrosis via suppressing DNA enrichment of STAT3.
  3. Interleukin-35 Is Involved in Angiogenesis/Bone Remodeling Coupling Through T Helper 17/Interleukin-17 Axis.
    Title: Interleukin-35 Is Involved in Angiogenesis/Bone Remodeling Coupling Through T Helper 17/Interleukin-17 Axis.
  4. Pancreatic cancer-associated inflammation drives dynamic regulation of p35 and Ebi3.
    Title: Pancreatic cancer-associated inflammation drives dynamic regulation of p35 and Ebi3.
  5. EBV-induced gene 3 augments IL-23Ralpha protein expression through a chaperone calnexin.
    Title: EBV-induced gene 3 augments IL-23Rα protein expression through a chaperone calnexin.
  6. Epigenetic histone modulation contributes to improvements in inflammatory bowel disease via EBI3.
    Title: Epigenetic histone modulation contributes to improvements in inflammatory bowel disease via EBI3.
  7. This study evaluated changes in new and maintenance DNA methylation profiles in the liver after 55 days of infection with Schistosoma mansoni.
    Title: Epigenetic and parasitological parameters are modulated in EBi3-/- mice infected with Schistosoma mansoni.
  8. IL-35 subunits (EBI3 and p35), which are mainly expressed in regulatory T cells, were upregulated in mice after myocardial infarction. IL-35 reduces cardiac rupture, improves wound healing, and attenuates cardiac remodeling after MI by promoting reparative CX3CR1(+)Ly6C(low) macrophage survival.
    Title: Interleukin-35 Promotes Macrophage Survival and Improves Wound Healing After Myocardial Infarction in Mice.
  9. we propose a novel mechanism for accumulating intracellular EBI3 and its regulation of macrophage apoptosis in response to virulent M. tb.
    Title: Accumulation of EBI3 induced by virulent Mycobacterium tuberculosis inhibits apoptosis in murine macrophages.
  10. In regulatory B cells, BATF, IFN regulatory factor, and IRF-8 transcription factors were recruited and bound to AP1-IRF-composite elements of il12a, ebi3, and/or il10 loci.
    Title: Production of IL-35 by Bregs is mediated through binding of BATF-IRF-4-IRF-8 complex to il12a and ebi3 promoter elements.
Submit: New GeneRIF Correction See all GeneRIFs (43)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
  
enables cytokine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytokine receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables interleukin-27 receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in T cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
interleukin-27 subunit beta
Names
IL-27 subunit beta
IL-27B
epstein-Barr virus-induced gene 3 protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015766.2 → NP_056581.1  interleukin-27 subunit beta precursor

    See identical proteins and their annotated locations for NP_056581.1

    Status: VALIDATED

    Source sequence(s)
    AW495532, BI134394, BY134465, CX240802
    Consensus CDS
    CCDS28888.1
    UniProtKB/Swiss-Prot
    O35228
    UniProtKB/TrEMBL
    Q3U1K3
    Related
    ENSMUSP00000003274.7, ENSMUST00000003274.8
    Conserved Domains (1) summary
    cd00063
    Location:128 → 216
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    56259623..56264022
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524599.5 → XP_006524662.1  interleukin-27 subunit beta isoform X1

    Conserved Domains (1) summary
    cd00063
    Location:27 → 115
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35228.1 GenPept UniProtKB/Swiss-Prot:O35228

Gene LinkOut

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