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AKAP13 A-kinase anchoring protein 13 [ Bos taurus (cattle) ]

Gene ID: 504288, updated on 3-Apr-2024

Summary

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Official Symbol
AKAP13provided by VGNC
Official Full Name
A-kinase anchoring protein 13provided by VGNC
Primary source
VGNC:VGNC:97238
See related
Ensembl:ENSBTAG00000037383
Gene type
protein coding
RefSeq status
MODEL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 21
Exon count:
44
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 21 NC_037348.1 (16215293..16539759)

Chromosome 21 - NC_037348.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132343334 Neighboring gene U6 spliceosomal RNA Neighboring gene kelch like family member 25 Neighboring gene transfer RNA cysteine (anticodon GCA)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037348.1 Chromosome 21 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables MAP-kinase scaffold activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in adrenergic receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
A-kinase anchor protein 13
Names
A kinase (PRKA) anchor protein 13

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037348.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    16215293..16539759
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024982287.2 → XP_024838055.2  A-kinase anchor protein 13 isoform X12

  2. XM_059879258.1 → XP_059735241.1  A-kinase anchor protein 13 isoform X3

  3. XM_059879260.1 → XP_059735243.1  A-kinase anchor protein 13 isoform X5

    Related
    ENSBTAP00000072392.2, ENSBTAT00000082517.2

  4. XM_059879263.1 → XP_059735246.1  A-kinase anchor protein 13 isoform X11

    Related
    ENSBTAP00000069506.2, ENSBTAT00000081683.2

  5. XM_059879256.1 → XP_059735239.1  A-kinase anchor protein 13 isoform X1

  6. XM_059879259.1 → XP_059735242.1  A-kinase anchor protein 13 isoform X4

  7. XM_059879261.1 → XP_059735244.1  A-kinase anchor protein 13 isoform X6

    Related
    ENSBTAP00000064350.2, ENSBTAT00000069851.2

  8. XM_059879257.1 → XP_059735240.1  A-kinase anchor protein 13 isoform X2

  9. XM_024982289.2 → XP_024838057.2  A-kinase anchor protein 13 isoform X7

  10. XM_059879262.1 → XP_059735245.1  A-kinase anchor protein 13 isoform X8

    Related
    ENSBTAP00000028060.7, ENSBTAT00000028060.7

  11. XM_024982293.2 → XP_024838061.2  A-kinase anchor protein 13 isoform X9

  12. XM_024982276.1 → XP_024838044.1  A-kinase anchor protein 13 isoform X10

    UniProtKB/TrEMBL
    A0A3Q1LUW4
    Related
    ENSBTAP00000076883.1, ENSBTAT00000106766.1
    Conserved Domains (9) summary
    cd00160
    Location:1994 → 2188
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13392
    Location:2231 → 2333
    PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain
    cl00040
    Location:1791 → 1834
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam10243
    Location:2607 → 2806
    MIP-T3; Microtubule-binding protein MIP-T3
    cl25602
    Location:2580 → 2690
    DUF3552; Domain of unknown function (DUF3552)
    cl25732
    Location:2191 → 2699
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26464
    Location:710 → 1031
    Atrophin-1; Atrophin-1 family
    cl28033
    Location:438 → 875
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    cl28267
    Location:1059 → 1390
    FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]

  13. XM_059879266.1 → XP_059735249.1  A-kinase anchor protein 13 isoform X15

  14. XM_024982295.2 → XP_024838063.1  A-kinase anchor protein 13 isoform X15

    UniProtKB/TrEMBL
    A0A3Q1LUW4
    Conserved Domains (9) summary
    cd00160
    Location:1708 → 1902
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13392
    Location:1945 → 2047
    PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain
    cl00040
    Location:1505 → 1548
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam10243
    Location:2321 → 2508
    MIP-T3; Microtubule-binding protein MIP-T3
    cl25602
    Location:2294 → 2404
    DUF3552; Domain of unknown function (DUF3552)
    cl25732
    Location:1953 → 2413
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26464
    Location:424 → 745
    Atrophin-1; Atrophin-1 family
    cl28033
    Location:152 → 589
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    cl28267
    Location:773 → 1088
    FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]

  15. XM_024982294.2 → XP_024838062.1  A-kinase anchor protein 13 isoform X14

    UniProtKB/TrEMBL
    A0A3Q1LUW4
    Conserved Domains (9) summary
    cd00160
    Location:1753 → 1947
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13392
    Location:1990 → 2092
    PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain
    cl00040
    Location:1550 → 1593
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam10243
    Location:2366 → 2565
    MIP-T3; Microtubule-binding protein MIP-T3
    cl25602
    Location:2339 → 2449
    DUF3552; Domain of unknown function (DUF3552)
    cl25732
    Location:1998 → 2458
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26464
    Location:469 → 790
    Atrophin-1; Atrophin-1 family
    cl28033
    Location:197 → 634
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    cl28267
    Location:818 → 1133
    FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]

  16. XM_059879265.1 → XP_059735248.1  A-kinase anchor protein 13 isoform X15

  17. XM_059879264.1 → XP_059735247.1  A-kinase anchor protein 13 isoform X13

  18. XM_024982297.2 → XP_024838065.1  A-kinase anchor protein 13 isoform X16

    Conserved Domains (6) summary
    cd00160
    Location:611 → 805
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13392
    Location:848 → 950
    PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain
    cl00040
    Location:409 → 452
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam10243
    Location:1213 → 1400
    MIP-T3; Microtubule-binding protein MIP-T3
    cl25602
    Location:1186 → 1296
    DUF3552; Domain of unknown function (DUF3552)
    cl25732
    Location:856 → 1305
    SMC_N; RecF/RecN/SMC N terminal domain
Nucleotide Protein Strain
Heading Accession and Version

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