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Apof apolipoprotein F [ Rattus norvegicus (Norway rat) ]

Gene ID: 500761, updated on 27-Apr-2024

Summary

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Official Symbol
Apofprovided by RGD
Official Full Name
apolipoprotein Fprovided by RGD
Primary source
RGD:1560713
See related
AllianceGenome:RGD:1560713
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in cholesterol metabolic process. Predicted to act upstream of or within cholesterol efflux and triglyceride metabolic process. Predicted to be part of high-density lipoprotein particle and low-density lipoprotein particle. Predicted to be active in extracellular space. Orthologous to human APOF (apolipoprotein F). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Expression
Restricted expression toward (RPKM 2086.3) See more
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Genomic context

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Location:
7q11
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (1285222..1286659)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (700688..702130)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (2689501..2690938)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene timeless circadian regulator Neighboring gene U6 spliceosomal RNA Neighboring gene apolipoprotein N Neighboring gene signal transducer and activator of transcription 2 Neighboring gene interleukin 23 subunit alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Absolute quantitation of disease protein biomarkers in a single LC-MS acquisition using apolipoprotein F as an example. Kumar A, et al. Sci Rep, 2017 Sep 21. PMID 28935895, Free PMC Article
  2. The effects of apolipoprotein F deficiency on high density lipoprotein cholesterol metabolism in mice. Lagor WR, et al. PLoS One, 2012. PMID 22363685, Free PMC Article
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within cholesterol efflux ISO
Inferred from Sequence Orthology
more info
  
involved_in cholesterol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within triglyceride metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of high-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
  
part_of low-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
apolipoprotein F
Names
apo-F
liver regeneration-related protein LRRG151

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001409538.1 → NP_001396467.1  apolipoprotein F precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the protein coding allele of rat strain SHR/Utx.
    Source sequence(s)
    CM042121

RNA

  1. NR_176857.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This is the non-coding allele of rat strain BN/NHsdMcwi.
    Source sequence(s)
    BC088170

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    1285222..1286659
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001024351.1: Suppressed sequence

    Description
    NM_001024351.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5M889.1 GenPept UniProtKB/Swiss-Prot:Q5M889

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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