Tpm2 tropomyosin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tpm2provided by RGD
Official Full Name: tropomyosin 2provided by RGD
Primary source: RGD:1559479
See related: Ensembl:ENSRNOG00000016731 AllianceGenome:RGD:1559479
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables actin filament binding activity; protein heterodimerization activity; and protein homodimerization activity. Predicted to be involved in actin filament organization; muscle contraction; and regulation of ATPase activity. Located in actin cytoskeleton. Human ortholog(s) of this gene implicated in distal arthrogryposis type 1A and nemaline myopathy 4. Orthologous to human TPM2 (tropomyosin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 16460.3) See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 5q22

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (62566712..62576066, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (57770919..57780278, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (59016616..59025971, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study identified a novel role of Smad4 SUMOylation and TPM2 in learning and memory formation. These results suggest that patients with skeletal myopathies who carry the TPM2E122K mutation may also have deficits in learning and memory functions.
Title: Smad4 SUMOylation is essential for memory formation through upregulation of the skeletal myopathy gene TPM2.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

BI277374 (e-PCR)
- UniSTS:243718

RH127874 (e-PCR)
- UniSTS:211184

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in muscle contraction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
is_active_in actin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: tropomyosin beta chain

Names: beta-tropomyosin; tropomyosin 2, beta

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024345.2 → NP_001019516.1 tropomyosin beta chain isoform Tpm2.1sm/cy

See identical proteins and their annotated locations for NP_001019516.1

Status: VALIDATED

Description

Transcript Variant: This variant (Tpm2.1, also known as variant 2) has an alternate internal exon and an alternate 3' exon, as compared to variant Tpm2.2. The resulting isoform (Tpm2.1sm/cy, also known as isoform 2) has a different internal segment and a different C-terminus, but has the same protein size, as compared to isoform Tpm2.2st.

Source sequence(s)

CF110059, CV796622, FQ223760

UniProtKB/TrEMBL

Q5FVG5

Related

ENSRNOP00000044473.4, ENSRNOT00000049000.7

Conserved Domains (1) summary

pfam00261
Location:48 → 282

Tropomyosin
NM_001301235.1 → NP_001288164.1 tropomyosin beta chain isoform Tpm2.2st

See identical proteins and their annotated locations for NP_001288164.1

Status: VALIDATED

Description

Transcript Variant: This variant (Tpm2.2, also known as variant 1) represents the longer transcript and encodes isoform Tpm2.2st (also known as isoform 1), which has the same protein size as isoform Tpm2.1sm/cy.

Source sequence(s)

FQ118075, FQ217483, FQ223760

UniProtKB/Swiss-Prot

P06395, P58775

Related

ENSRNOP00000022801.6, ENSRNOT00000022801.7

Conserved Domains (1) summary

pfam00261
Location:48 → 282

Tropomyosin