Naaa N-acylethanolamine acid amidase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Naaaprovided by RGD
Official Full Name: N-acylethanolamine acid amidaseprovided by RGD
Primary source: RGD:1307267
See related: Ensembl:ENSRNOG00000002273 AllianceGenome:RGD:1307267
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Asahl
Summary: Enables N-(long-chain-acyl)ethanolamine deacylase activity. Involved in N-acylethanolamine metabolic process. Predicted to be located in lysosome. Predicted to be extrinsic component of membrane. Orthologous to human NAAA (N-acylethanolamine acid amidase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 459.9), Spleen (RPKM 127.0) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p22

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (16061599..16080703)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (15777306..15796411)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (17283262..17302364)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Taken together, this study identified the association between NAAA and steoarthritis (OA) progression, and suggested that NAAA inhibitors could be a novel therapeutic approach for OA.
Title: N-Acylethanolamine acid amidase (NAAA) inhibitor F215 as a novel therapeutic agent for osteoarthritis.
mRNA and protein levels and activity of NAAA in alveolar macrophages are much higher than those in the whole lung tissue.
Title: Predominant expression of lysosomal N-acylethanolamine-hydrolyzing acid amidase in macrophages revealed by immunochemical studies.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables N-(long-chain-acyl)ethanolamine deacylase activity	IDA Inferred from Direct Assay more info	PubMed
enables N-(long-chain-acyl)ethanolamine deacylase activity	ISO Inferred from Sequence Orthology more info
enables N-(long-chain-acyl)ethanolamine deacylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables N-acylsphingosine amidohydrolase activity	ISO Inferred from Sequence Orthology more info
enables N-acylsphingosine amidohydrolase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ceramidase activity	IEA Inferred from Electronic Annotation more info
enables fatty acid amide hydrolase activity	ISO Inferred from Sequence Orthology more info
enables fatty acid amide hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in N-acylethanolamine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in N-acylethanolamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in N-acylethanolamine metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in N-acylphosphatidylethanolamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in N-acylphosphatidylethanolamine metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in sphingosine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in sphingosine metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: N-acylethanolamine-hydrolyzing acid amidase

Names: ASAH-like protein; acylsphingosine deacylase NAAA

NP_001010967.1

EC 3.5.1.23

EC 3.5.1.60

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001010967.2 → NP_001010967.1 N-acylethanolamine-hydrolyzing acid amidase precursor

See identical proteins and their annotated locations for NP_001010967.1

Status: PROVISIONAL

Source sequence(s)

BC105771

UniProtKB/Swiss-Prot

Q3KRD3, Q5KTC7

UniProtKB/TrEMBL

A6KK97

Related

ENSRNOP00000003102.5, ENSRNOT00000003102.7

Conserved Domains (2) summary

cd01903
Location:122 → 351

Ntn_AC_NAAA; AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA). AC catalyzes the hydrolysis of ceramide to sphingosine and ...

pfam15508
Location:36 → 126

NAAA-beta; beta subunit of N-acylethanolamine-hydrolyzing acid amidase