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nsfl1c NSFL1 (p97) cofactor (p47) [ Danio rerio (zebrafish) ]

Gene ID: 492805, updated on 27-Mar-2024

Summary

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Official Symbol
nsfl1cprovided by ZNC
Official Full Name
NSFL1 (p97) cofactor (p47)provided by ZNC
Primary source
ZFIN:ZDB-GENE-041114-160
See related
Ensembl:ENSDARG00000087640 AllianceGenome:ZFIN:ZDB-GENE-041114-160
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zehn2383; wu:fc88f08; zgc:101636; hm:zehn2383
Summary
Predicted to enable ubiquitin binding activity. Predicted to be involved in several processes, including autophagosome assembly; nuclear membrane reassembly; and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in Golgi stack. Predicted to be active in cytosol and nucleus. Orthologous to human NSFL1C (NSFL1 cofactor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See nsfl1c in Genome Data Viewer
Location:
chromosome: 23
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (18794832..18805565, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (18868489..18879222, complement)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily C, member 4 associated protein b Neighboring gene epithelial membrane protein 3b (MAM blood group) Neighboring gene wu:fa11c10 Neighboring gene si:ch211-209j10.6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Dynamics of Zebrafish Heart Regeneration Using an HPLC-ESI-MS/MS Approach. Ma D, et al. J Proteome Res, 2018 Mar 2. PMID 29369637
  2. Identification, characterization, and mapping of expressed sequence tags from an embryonic zebrafish heart cDNA library. Ton C, et al. Genome Res, 2000 Dec. PMID 11116087, Free PMC Article
  3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in membrane fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear membrane reassembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi stack IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
NSFL1 cofactor p47

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007446.1 → NP_001007447.1  NSFL1 cofactor p47

    See identical proteins and their annotated locations for NP_001007447.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085395
    UniProtKB/TrEMBL
    Q5U3U1
    Related
    ENSDARP00000115283.1, ENSDART00000143065.3
    Conserved Domains (3) summary
    cd01770
    Location:294 → 372
    p47_UBX; p47-like ubiquitin domain
    smart00553
    Location:181 → 270
    SEP; Domain present in Saccharomyces cerevisiae Shp1, Drosophila melanogaster eyes closed gene (eyc), and vertebrate p47
    cd14348
    Location:5 → 44
    UBA_p47; UBA-like domain found in NSFL1 cofactor p47 and similar proteins

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    18794832..18805565 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009296732.1 → XP_009295007.1  NSFL1 cofactor p47 isoform X1

    UniProtKB/TrEMBL
    A0A8M3AV68
    Conserved Domains (3) summary
    cd01770
    Location:293 → 371
    p47_UBX; p47-like ubiquitin domain
    smart00553
    Location:178 → 269
    SEP; Domain present in Saccharomyces cerevisiae Shp1, Drosophila melanogaster eyes closed gene (eyc), and vertebrate p47
    cd14348
    Location:5 → 44
    UBA_p47; UBA-like domain found in NSFL1 cofactor p47 and similar proteins

  2. XM_021469793.1 → XP_021325468.1  NSFL1 cofactor p47 isoform X2

    UniProtKB/TrEMBL
    A0A8M9PF11
    Conserved Domains (2) summary
    cd14348
    Location:5 → 44
    UBA_p47; UBA-like domain found in NSFL1 cofactor p47 and similar proteins
    cl02662
    Location:178 → 216
    SEP; SEP domain
Nucleotide Protein Strain
Heading Accession and Version

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