ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif 5 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: ADAMTS5provided by VGNC
Official Full Name: ADAM metallopeptidase with thrombospondin type 1 motif 5provided by VGNC
Primary source: VGNC:VGNC:37601
See related: Ensembl:ENSCAFG00845018095
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 31

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	31	NC_051835.1 (22341143..22388689, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	31	NC_006613.4 (22237302..22284778, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	31	NC_049252.1 (22794062..22841615, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	31	NC_049291.1 (22313499..22361201, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	31	NC_049772.1 (22319121..22366648, complement)

Chromosome 31 - NC_051835.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Adamts5 (e-PCR), detects polymorphism
- UniSTS:259033

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in extracellular matrix organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: A disintegrin and metalloproteinase with thrombospondin motifs 5; LOW QUALITY PROTEIN: A disintegrin and metalloproteinase with thrombospondin motifs 5

Names: ADAM metallopeptidase with thrombospondin type 1 motif, 5 (aggrecanase-2)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051835.1 Reference ROS_Cfam_1.0

Range

22341143..22388689 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038443286.1 → XP_038299214.1 A disintegrin and metalloproteinase with thrombospondin motifs 5

UniProtKB/TrEMBL

A0A8C0TFB3, A0A8I3P533, A0A8P0SDL0

Related

ENSCAFP00845025040.1, ENSCAFT00845032021.1

Conserved Domains (6) summary

smart00209
Location:574 → 626

TSP1; Thrombospondin type 1 repeats

cd04273
Location:273 → 477

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam05986
Location:736 → 856

ADAM_spacer1; ADAM-TS Spacer 1

pfam01562
Location:60 → 172

Pep_M12B_propep; Reprolysin family propeptide

pfam17771
Location:491 → 558

ADAM_CR_2; ADAM cysteine-rich domain

pfam19030
Location:883 → 934

TSP1_ADAMTS; Thrombospondin type 1 domain

Alternate UMICH_Zoey_3.1

Genomic

NC_049291.1 Alternate UMICH_Zoey_3.1

Range

22313499..22361201 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038517701.1 → XP_038373629.1 LOW QUALITY PROTEIN: A disintegrin and metalloproteinase with thrombospondin motifs 5

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049772.1 Alternate UNSW_CanFamBas_1.0

Range

22319121..22366648 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038645660.1 → XP_038501588.1 A disintegrin and metalloproteinase with thrombospondin motifs 5

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049252.1 Alternate UU_Cfam_GSD_1.0

Range

22794062..22841615 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038581284.1 → XP_038437212.1 A disintegrin and metalloproteinase with thrombospondin motifs 5

UniProtKB/TrEMBL

A0A8C0TFB3

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006613.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

22237302..22284778 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_846025.5 → XP_851118.3 A disintegrin and metalloproteinase with thrombospondin motifs 5

UniProtKB/TrEMBL

A0A8C0TFB3, A0A8I3P533, A0A8P0SDL0

Conserved Domains (6) summary

smart00209
Location:574 → 626

TSP1; Thrombospondin type 1 repeats

cd04273
Location:273 → 477

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam05986
Location:736 → 856

ADAM_spacer1; ADAM-TS Spacer 1

pfam01562
Location:60 → 172

Pep_M12B_propep; Reprolysin family propeptide

pfam17771
Location:491 → 558

ADAM_CR_2; ADAM cysteine-rich domain

pfam19030
Location:883 → 934

TSP1_ADAMTS; Thrombospondin type 1 domain