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A2ML1 alpha-2-macroglobulin like 1 [ Canis lupus familiaris (dog) ]

Gene ID: 486697, updated on 5-Mar-2024

Summary

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Official Symbol
A2ML1provided by VGNC
Official Full Name
alpha-2-macroglobulin like 1provided by VGNC
Primary source
VGNC:VGNC:37400
See related
Ensembl:ENSCAFG00845029001
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human all
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Genomic context

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Location:
chromosome: 27
Exon count:
30
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 27 NC_051831.1 (37193157..37223156, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 27 NC_006609.4 (9742223..9772407)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 27 NC_049248.1 (9250894..9303905)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 27 NC_049287.1 (37073782..37103765, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 27 NC_049768.1 (37108930..37138923, complement)

Chromosome 27 - NC_051831.1Genomic Context describing neighboring genes Neighboring gene translation initiation factor IF-2-like Neighboring gene polyhomeotic homolog 1 Neighboring gene uncharacterized LOC111092831 Neighboring gene uncharacterized LOC119866426 Neighboring gene U6 spliceosomal RNA Neighboring gene ribosomal modification protein rimK like family member B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
alpha-2-macroglobulin-like protein 1; LOW QUALITY PROTEIN: alpha-2-macroglobulin-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051831.1 Reference ROS_Cfam_1.0

    Range
    37193157..37223156 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038437910.1 → XP_038293838.1  alpha-2-macroglobulin-like protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I3S725
    Conserved Domains (6) summary
    cd02897
    Location:650 → 945
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:430 → 520
    A2M; Alpha-2-macroglobulin family
    pfam05326
    Location:482 → 565
    SVA; Seminal vesicle autoantigen (SVA)
    pfam07677
    Location:1056 → 1109
    A2M_recep; A-macroglobulin receptor
    pfam07703
    Location:158 → 304
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    pfam17789
    Location:45 → 142
    MG4; Macroglobulin domain MG4

  2. XM_038437909.1 → XP_038293837.1  alpha-2-macroglobulin-like protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I3S725
    Related
    ENSCAFP00845040580.1, ENSCAFT00845051722.1
    Conserved Domains (6) summary
    cd02897
    Location:650 → 945
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:430 → 520
    A2M; Alpha-2-macroglobulin family
    pfam05326
    Location:482 → 565
    SVA; Seminal vesicle autoantigen (SVA)
    pfam07677
    Location:1056 → 1109
    A2M_recep; A-macroglobulin receptor
    pfam07703
    Location:158 → 304
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    pfam17789
    Location:45 → 142
    MG4; Macroglobulin domain MG4

  3. XM_038437911.1 → XP_038293839.1  alpha-2-macroglobulin-like protein 1 isoform X1

    Conserved Domains (5) summary
    cd02897
    Location:650 → 933
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:430 → 520
    A2M; Alpha-2-macroglobulin family
    pfam05326
    Location:482 → 565
    SVA; Seminal vesicle autoantigen (SVA)
    pfam07703
    Location:158 → 304
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    pfam17789
    Location:45 → 142
    MG4; Macroglobulin domain MG4

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049287.1 Alternate UMICH_Zoey_3.1

    Range
    37073782..37103765 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038514319.1 → XP_038370247.1  alpha-2-macroglobulin-like protein 1 isoform X3

    Conserved Domains (6) summary
    cd02897
    Location:650 → 945
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:430 → 520
    A2M; Alpha-2-macroglobulin family
    pfam05326
    Location:482 → 565
    SVA; Seminal vesicle autoantigen (SVA)
    pfam07677
    Location:1056 → 1143
    A2M_recep; A-macroglobulin receptor
    pfam07703
    Location:158 → 304
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    pfam17789
    Location:45 → 142
    MG4; Macroglobulin domain MG4

  2. XM_038514318.1 → XP_038370246.1  alpha-2-macroglobulin-like protein 1 isoform X3

    Conserved Domains (6) summary
    cd02897
    Location:650 → 945
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:430 → 520
    A2M; Alpha-2-macroglobulin family
    pfam05326
    Location:482 → 565
    SVA; Seminal vesicle autoantigen (SVA)
    pfam07677
    Location:1056 → 1143
    A2M_recep; A-macroglobulin receptor
    pfam07703
    Location:158 → 304
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    pfam17789
    Location:45 → 142
    MG4; Macroglobulin domain MG4

  3. XM_038514320.1 → XP_038370248.1  alpha-2-macroglobulin-like protein 1 isoform X1

    Conserved Domains (5) summary
    cd02897
    Location:650 → 933
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:430 → 520
    A2M; Alpha-2-macroglobulin family
    pfam05326
    Location:482 → 565
    SVA; Seminal vesicle autoantigen (SVA)
    pfam07703
    Location:158 → 304
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    pfam17789
    Location:45 → 142
    MG4; Macroglobulin domain MG4

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049768.1 Alternate UNSW_CanFamBas_1.0

    Range
    37108930..37138923 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038640365.1 → XP_038496293.1  alpha-2-macroglobulin-like protein 1 isoform X4

    Conserved Domains (6) summary
    cd02897
    Location:650 → 945
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:430 → 520
    A2M; Alpha-2-macroglobulin family
    pfam05326
    Location:482 → 565
    SVA; Seminal vesicle autoantigen (SVA)
    pfam07677
    Location:1056 → 1143
    A2M_recep; A-macroglobulin receptor
    pfam07703
    Location:158 → 304
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    pfam17789
    Location:45 → 142
    MG4; Macroglobulin domain MG4

  2. XM_038640364.1 → XP_038496292.1  alpha-2-macroglobulin-like protein 1 isoform X4

    Conserved Domains (6) summary
    cd02897
    Location:650 → 945
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:430 → 520
    A2M; Alpha-2-macroglobulin family
    pfam05326
    Location:482 → 565
    SVA; Seminal vesicle autoantigen (SVA)
    pfam07677
    Location:1056 → 1143
    A2M_recep; A-macroglobulin receptor
    pfam07703
    Location:158 → 304
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    pfam17789
    Location:45 → 142
    MG4; Macroglobulin domain MG4

  3. XM_038640366.1 → XP_038496294.1  alpha-2-macroglobulin-like protein 1 isoform X1

    Conserved Domains (5) summary
    cd02897
    Location:650 → 933
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:430 → 520
    A2M; Alpha-2-macroglobulin family
    pfam05326
    Location:482 → 565
    SVA; Seminal vesicle autoantigen (SVA)
    pfam07703
    Location:158 → 304
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    pfam17789
    Location:45 → 142
    MG4; Macroglobulin domain MG4

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049248.1 Alternate UU_Cfam_GSD_1.0

    Range
    9250894..9303905
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038577899.1 → XP_038433827.1  LOW QUALITY PROTEIN: alpha-2-macroglobulin-like protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A8P0SIT8

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006609.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    9742223..9772407
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038459500.1 → XP_038315428.1  alpha-2-macroglobulin-like protein 1 isoform X6

    UniProtKB/TrEMBL
    A0A8P0NQ75
    Conserved Domains (6) summary
    cd02897
    Location:650 → 945
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:430 → 520
    A2M; Alpha-2-macroglobulin family
    pfam05326
    Location:482 → 565
    SVA; Seminal vesicle autoantigen (SVA)
    pfam07677
    Location:1056 → 1143
    A2M_recep; A-macroglobulin receptor
    pfam07703
    Location:158 → 304
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    pfam17789
    Location:45 → 142
    MG4; Macroglobulin domain MG4

  2. XM_038459501.1 → XP_038315429.1  alpha-2-macroglobulin-like protein 1 isoform X1

    Conserved Domains (5) summary
    cd02897
    Location:650 → 933
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:430 → 520
    A2M; Alpha-2-macroglobulin family
    pfam05326
    Location:482 → 565
    SVA; Seminal vesicle autoantigen (SVA)
    pfam07703
    Location:158 → 304
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    pfam17789
    Location:45 → 142
    MG4; Macroglobulin domain MG4
Nucleotide Protein
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