LRWD1 leucine rich repeats and WD repeat domain containing 1 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: LRWD1provided by VGNC
Official Full Name: leucine rich repeats and WD repeat domain containing 1provided by VGNC
Primary source: VGNC:VGNC:42835
See related: Ensembl:ENSCAFG00845004759
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	6	NC_051810.1 (7531220..7537350, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	6	NC_006588.4 (9406064..9412193, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	6	NC_049227.1 (7626509..7632639, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	6	NC_049266.1 (7499730..7505854, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	6	NC_049747.1 (7462794..7468922, complement)

Chromosome 6 - NC_051810.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables chromatin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in establishment of protein localization to chromatin	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of nuclear origin of replication recognition complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: leucine-rich repeat and WD repeat-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051810.1 Reference ROS_Cfam_1.0

Range

7531220..7537350 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038667959.1 → XP_038523887.1 leucine-rich repeat and WD repeat-containing protein 1 isoform X3

UniProtKB/TrEMBL

A0A8C0MMJ4

Conserved Domains (4) summary

sd00031
Location:23 → 48

LRR_1; leucine-rich repeat [structural motif]

sd00039
Location:242 → 285

7WD40; WD40 repeat [structural motif]

cd21340
Location:29 → 140

PPP1R42; protein phosphatase 1 regulatory subunit 42

cl29593
Location:334 → 533

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_038667957.1 → XP_038523885.1 leucine-rich repeat and WD repeat-containing protein 1 isoform X1

UniProtKB/TrEMBL

A0A8C0KJT9, A0A8C0MMJ4, A0A8C0QER7, A0A8I3MRC9

Related

ENSCAFP00845006742.1, ENSCAFT00845008543.1

Conserved Domains (4) summary

sd00031
Location:23 → 48

LRR_1; leucine-rich repeat [structural motif]

sd00039
Location:288 → 331

7WD40; WD40 repeat [structural motif]

cd21340
Location:29 → 140

PPP1R42; protein phosphatase 1 regulatory subunit 42

cl29593
Location:380 → 579

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_038667960.1 → XP_038523888.1 leucine-rich repeat and WD repeat-containing protein 1 isoform X4

UniProtKB/TrEMBL

A0A8C0MMJ4

Conserved Domains (4) summary

sd00031
Location:23 → 48

LRR_1; leucine-rich repeat [structural motif]

sd00039
Location:203 → 246

7WD40; WD40 repeat [structural motif]

cd21340
Location:29 → 116

PPP1R42; protein phosphatase 1 regulatory subunit 42

cl29593
Location:295 → 494

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_038667958.1 → XP_038523886.1 leucine-rich repeat and WD repeat-containing protein 1 isoform X2

UniProtKB/TrEMBL

A0A8C0MMJ4

Conserved Domains (4) summary

sd00031
Location:23 → 48

LRR_1; leucine-rich repeat [structural motif]

sd00039
Location:249 → 292

7WD40; WD40 repeat [structural motif]

cd21340
Location:29 → 112

PPP1R42; protein phosphatase 1 regulatory subunit 42

cl29593
Location:341 → 540

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

Alternate UMICH_Zoey_3.1

Genomic

NC_049266.1 Alternate UMICH_Zoey_3.1

Range

7499730..7505854 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038477926.1 → XP_038333854.1 leucine-rich repeat and WD repeat-containing protein 1 isoform X3

Conserved Domains (4) summary

sd00031
Location:23 → 48

LRR_1; leucine-rich repeat [structural motif]

sd00039
Location:242 → 285

7WD40; WD40 repeat [structural motif]

cd21340
Location:29 → 140

PPP1R42; protein phosphatase 1 regulatory subunit 42

cl29593
Location:334 → 533

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_038477924.1 → XP_038333852.1 leucine-rich repeat and WD repeat-containing protein 1 isoform X1

Conserved Domains (4) summary

sd00031
Location:23 → 48

LRR_1; leucine-rich repeat [structural motif]

sd00039
Location:288 → 331

7WD40; WD40 repeat [structural motif]

cd21340
Location:29 → 140

PPP1R42; protein phosphatase 1 regulatory subunit 42

cl29593
Location:380 → 579

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_038477927.1 → XP_038333855.1 leucine-rich repeat and WD repeat-containing protein 1 isoform X4

Conserved Domains (4) summary

sd00031
Location:23 → 48

LRR_1; leucine-rich repeat [structural motif]

sd00039
Location:203 → 246

7WD40; WD40 repeat [structural motif]

cd21340
Location:29 → 116

PPP1R42; protein phosphatase 1 regulatory subunit 42

cl29593
Location:295 → 494

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_038477925.1 → XP_038333853.1 leucine-rich repeat and WD repeat-containing protein 1 isoform X2

Conserved Domains (4) summary

sd00031
Location:23 → 48

LRR_1; leucine-rich repeat [structural motif]

sd00039
Location:249 → 292

7WD40; WD40 repeat [structural motif]

cd21340
Location:29 → 112

PPP1R42; protein phosphatase 1 regulatory subunit 42

cl29593
Location:341 → 540

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049747.1 Alternate UNSW_CanFamBas_1.0

Range

7462794..7468922 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038603259.1 → XP_038459187.1 leucine-rich repeat and WD repeat-containing protein 1 isoform X3
XM_038603257.1 → XP_038459185.1 leucine-rich repeat and WD repeat-containing protein 1 isoform X1
XM_038603260.1 → XP_038459188.1 leucine-rich repeat and WD repeat-containing protein 1 isoform X4
XM_038603258.1 → XP_038459186.1 leucine-rich repeat and WD repeat-containing protein 1 isoform X2

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049227.1 Alternate UU_Cfam_GSD_1.0

Range

7626509..7632639 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038539175.1 → XP_038395103.1 leucine-rich repeat and WD repeat-containing protein 1 isoform X3

UniProtKB/TrEMBL

A0A8C0MMJ4
XM_038539172.1 → XP_038395100.1 leucine-rich repeat and WD repeat-containing protein 1 isoform X1

UniProtKB/TrEMBL

A0A8C0MMJ4, A0A8P0SII1
XM_038539174.1 → XP_038395102.1 leucine-rich repeat and WD repeat-containing protein 1 isoform X2

UniProtKB/TrEMBL

A0A8C0MMJ4

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006588.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

9406064..9412193 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_022419598.1 → XP_022275306.1 leucine-rich repeat and WD repeat-containing protein 1 isoform X3

UniProtKB/TrEMBL

A0A8C0MMJ4

Conserved Domains (4) summary

COG4886
Location:15 → 121

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00031
Location:23 → 48

LRR_1; leucine-rich repeat [structural motif]

sd00039
Location:242 → 285

7WD40; WD40 repeat [structural motif]

cl25539
Location:334 → 533

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_536851.5 → XP_536851.3 leucine-rich repeat and WD repeat-containing protein 1 isoform X1

UniProtKB/TrEMBL

A0A8C0MMJ4, A0A8P0SII1

Conserved Domains (6) summary

COG2319
Location:237 → 579

WD40; WD40 repeat [General function prediction only]

sd00031
Location:23 → 48

LRR_1; leucine-rich repeat [structural motif]

pfam12799
Location:47 → 87

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:22 → 81

LRR_8; Leucine rich repeat

sd00039
Location:288 → 331

7WD40; WD40 repeat [structural motif]

cl02567
Location:380 → 579

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_005620992.4 → XP_005621049.1 leucine-rich repeat and WD repeat-containing protein 1 isoform X2

UniProtKB/TrEMBL

A0A8C0MMJ4

Conserved Domains (6) summary

COG2319
Location:198 → 540

WD40; WD40 repeat [General function prediction only]

sd00031
Location:23 → 48

LRR_1; leucine-rich repeat [structural motif]

pfam12799
Location:47 → 87

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:22 → 81

LRR_8; Leucine rich repeat

sd00039
Location:249 → 292

7WD40; WD40 repeat [structural motif]

cl02567
Location:341 → 540

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...