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ADAM2 ADAM metallopeptidase domain 2 [ Canis lupus familiaris (dog) ]

Gene ID: 475576, updated on 5-Mar-2024

Summary

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Official Symbol
ADAM2provided by VGNC
Official Full Name
ADAM metallopeptidase domain 2provided by VGNC
Primary source
VGNC:VGNC:111327
See related
Ensembl:ENSCAFG00845010086
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 16
Exon count:
20
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 16 NC_051820.1 (27604238..27740761, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 16 NC_006598.4 (26296840..26434482, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 16 NC_049237.1 (26520781..26651970, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 16 NC_049276.1 (25906520..26037639, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 16 NC_049757.1 (26466004..26599845, complement)

Chromosome 16 - NC_051820.1Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase domain 18 Neighboring gene malate dehydrogenase, mitochondrial-like Neighboring gene proteasome subunit alpha type-7-like Neighboring gene uncharacterized LOC111090163 Neighboring gene A disintegrin and metallopeptidase domain 3-like Neighboring gene tumor necrosis factor receptor superfamily, member 21 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in binding of sperm to zona pellucida IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
disintegrin and metalloproteinase domain-containing protein 2
Names
ADAM metallopeptidase domain 2 (fertilin beta)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051820.1 Reference ROS_Cfam_1.0

    Range
    27604238..27740761 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038689807.1 → XP_038545735.1  disintegrin and metalloproteinase domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I3NFK7
    Related
    ENSCAFP00845014212.1, ENSCAFT00845018223.1
    Conserved Domains (4) summary
    smart00050
    Location:312 → 389
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:391 → 527
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:98 → 295
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:7 → 61
    Pep_M12B_propep; Reprolysin family propeptide

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049276.1 Alternate UMICH_Zoey_3.1

    Range
    25906520..26037639 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038497559.1 → XP_038353487.1  disintegrin and metalloproteinase domain-containing protein 2 isoform X6

    Conserved Domains (4) summary
    smart00050
    Location:327 → 404
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:406 → 542
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:113 → 310
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:43 → 120
    Pep_M12B_propep; Reprolysin family propeptide

  2. XM_038497560.1 → XP_038353488.1  disintegrin and metalloproteinase domain-containing protein 2 isoform X7

    Conserved Domains (4) summary
    smart00050
    Location:293 → 370
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:372 → 508
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:162 → 276
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:43 → 125
    Pep_M12B_propep; Reprolysin family propeptide

  3. XM_038497557.1 → XP_038353485.1  disintegrin and metalloproteinase domain-containing protein 2 isoform X4

    Conserved Domains (4) summary
    smart00050
    Location:376 → 420
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:422 → 558
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:162 → 359
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:43 → 125
    Pep_M12B_propep; Reprolysin family propeptide

  4. XM_038497555.1 → XP_038353483.1  disintegrin and metalloproteinase domain-containing protein 2 isoform X2

    Conserved Domains (4) summary
    smart00050
    Location:376 → 453
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:455 → 591
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:162 → 359
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:43 → 125
    Pep_M12B_propep; Reprolysin family propeptide

  5. XM_038497558.1 → XP_038353486.1  disintegrin and metalloproteinase domain-containing protein 2 isoform X5

    Conserved Domains (4) summary
    smart00050
    Location:376 → 453
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:455 → 591
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:162 → 359
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:43 → 125
    Pep_M12B_propep; Reprolysin family propeptide

  6. XM_038497556.1 → XP_038353484.1  disintegrin and metalloproteinase domain-containing protein 2 isoform X3

  7. XM_038497561.1 → XP_038353489.1  disintegrin and metalloproteinase domain-containing protein 2 isoform X8

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049757.1 Alternate UNSW_CanFamBas_1.0

    Range
    26466004..26599845 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038624055.1 → XP_038479983.1  disintegrin and metalloproteinase domain-containing protein 2 isoform X13

    Conserved Domains (4) summary
    smart00050
    Location:327 → 404
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:406 → 542
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:113 → 310
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:43 → 120
    Pep_M12B_propep; Reprolysin family propeptide

  2. XM_038624056.1 → XP_038479984.1  disintegrin and metalloproteinase domain-containing protein 2 isoform X14

    Conserved Domains (4) summary
    smart00050
    Location:293 → 370
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:372 → 508
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:162 → 276
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:43 → 125
    Pep_M12B_propep; Reprolysin family propeptide

  3. XM_038624053.1 → XP_038479981.1  disintegrin and metalloproteinase domain-containing protein 2 isoform X11

    Conserved Domains (4) summary
    smart00050
    Location:376 → 420
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:422 → 558
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:162 → 359
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:43 → 125
    Pep_M12B_propep; Reprolysin family propeptide

  4. XM_038624051.1 → XP_038479979.1  disintegrin and metalloproteinase domain-containing protein 2 isoform X9

    Conserved Domains (4) summary
    smart00050
    Location:376 → 453
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:455 → 591
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:162 → 359
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:43 → 125
    Pep_M12B_propep; Reprolysin family propeptide

  5. XM_038624054.1 → XP_038479982.1  disintegrin and metalloproteinase domain-containing protein 2 isoform X12

    Conserved Domains (4) summary
    smart00050
    Location:376 → 453
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:455 → 591
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:162 → 359
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:43 → 125
    Pep_M12B_propep; Reprolysin family propeptide

  6. XM_038624052.1 → XP_038479980.1  disintegrin and metalloproteinase domain-containing protein 2 isoform X10

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049237.1 Alternate UU_Cfam_GSD_1.0

    Range
    26520781..26651970 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038560010.1 → XP_038415938.1  disintegrin and metalloproteinase domain-containing protein 2 isoform X19

    UniProtKB/TrEMBL
    A0A8P0TL67
    Conserved Domains (4) summary
    smart00050
    Location:327 → 404
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:406 → 542
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:113 → 310
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:43 → 120
    Pep_M12B_propep; Reprolysin family propeptide

  2. XM_038560011.1 → XP_038415939.1  disintegrin and metalloproteinase domain-containing protein 2 isoform X20

    UniProtKB/TrEMBL
    A0A8P0TL67
    Conserved Domains (4) summary
    smart00050
    Location:293 → 370
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:372 → 508
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:162 → 276
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:43 → 125
    Pep_M12B_propep; Reprolysin family propeptide

  3. XM_038560008.1 → XP_038415936.1  disintegrin and metalloproteinase domain-containing protein 2 isoform X17

    UniProtKB/TrEMBL
    A0A8P0TL67
    Conserved Domains (4) summary
    smart00050
    Location:376 → 420
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:422 → 558
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:162 → 359
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:43 → 125
    Pep_M12B_propep; Reprolysin family propeptide

  4. XM_038560006.1 → XP_038415934.1  disintegrin and metalloproteinase domain-containing protein 2 isoform X15

    UniProtKB/TrEMBL
    A0A8P0TL67
    Conserved Domains (4) summary
    smart00050
    Location:376 → 453
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:455 → 591
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:162 → 359
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:43 → 125
    Pep_M12B_propep; Reprolysin family propeptide

  5. XM_038560009.1 → XP_038415937.1  disintegrin and metalloproteinase domain-containing protein 2 isoform X18

    UniProtKB/TrEMBL
    A0A8P0TL67
    Conserved Domains (4) summary
    smart00050
    Location:376 → 453
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:455 → 591
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:162 → 359
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:43 → 125
    Pep_M12B_propep; Reprolysin family propeptide

  6. XM_038560007.1 → XP_038415935.1  disintegrin and metalloproteinase domain-containing protein 2 isoform X16

    UniProtKB/TrEMBL
    A0A8C0MWY3, A0A8P0P9C6

  7. XM_038560012.1 → XP_038415940.1  disintegrin and metalloproteinase domain-containing protein 2 isoform X21

    UniProtKB/TrEMBL
    A0A8C0MWY3, A0A8C0N3U8, A0A8P0P9C6, A0A8P0SQX4

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006598.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    26296840..26434482 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038452693.1 → XP_038308621.1  disintegrin and metalloproteinase domain-containing protein 2 isoform X26

    UniProtKB/TrEMBL
    A0A8P0TL67
    Conserved Domains (4) summary
    smart00050
    Location:327 → 404
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:406 → 542
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:113 → 310
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:43 → 120
    Pep_M12B_propep; Reprolysin family propeptide

  2. XM_038452694.1 → XP_038308622.1  disintegrin and metalloproteinase domain-containing protein 2 isoform X27

    UniProtKB/TrEMBL
    A0A8P0TL67
    Conserved Domains (4) summary
    smart00050
    Location:293 → 370
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:372 → 508
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:162 → 276
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:43 → 125
    Pep_M12B_propep; Reprolysin family propeptide

  3. XM_038452691.1 → XP_038308619.1  disintegrin and metalloproteinase domain-containing protein 2 isoform X24

    UniProtKB/TrEMBL
    A0A8P0TL67
    Conserved Domains (4) summary
    smart00050
    Location:376 → 420
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:422 → 558
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:162 → 359
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:43 → 125
    Pep_M12B_propep; Reprolysin family propeptide

  4. XM_022404019.1 → XP_022259727.1  disintegrin and metalloproteinase domain-containing protein 2 isoform X22

    UniProtKB/TrEMBL
    A0A8P0TL67
    Conserved Domains (4) summary
    smart00050
    Location:376 → 453
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:455 → 591
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:162 → 359
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:43 → 125
    Pep_M12B_propep; Reprolysin family propeptide

  5. XM_038452692.1 → XP_038308620.1  disintegrin and metalloproteinase domain-containing protein 2 isoform X25

    UniProtKB/TrEMBL
    A0A8P0TL67
    Conserved Domains (4) summary
    smart00050
    Location:376 → 453
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:455 → 591
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:162 → 359
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:43 → 125
    Pep_M12B_propep; Reprolysin family propeptide

  6. XM_022404017.2 → XP_022259725.1  disintegrin and metalloproteinase domain-containing protein 2 isoform X23

    UniProtKB/TrEMBL
    A0A8C0MWY3, A0A8P0P9C6
    Conserved Domains (4) summary
    smart00050
    Location:392 → 469
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:471 → 607
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:178 → 375
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:26 → 141
    Pep_M12B_propep; Reprolysin family propeptide
Nucleotide Protein
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