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ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif 5 [ Pan troglodytes (chimpanzee) ]

Gene ID: 473935, updated on 29-Mar-2024

Summary

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Official Symbol
ADAMTS5provided by VGNC
Official Full Name
ADAM metallopeptidase with thrombospondin type 1 motif 5provided by VGNC
Primary source
VGNC:VGNC:3744
Locus tag
CK820_G0018212
See related
Ensembl:ENSPTRG00000013814
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 21
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 22 NC_072420.2 (27694103..27743444, complement)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 21 NC_072419.1 (25326531..25376674, complement)

Chromosome 22 - NC_072420.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC129138315 Neighboring gene cysteine and tyrosine rich 1 Neighboring gene ribosomal protein lateral stalk subunit P1 pseudogene Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 1 Neighboring gene glutathione peroxidase 1-like Neighboring gene uncharacterized LOC129138281

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
A disintegrin and metalloproteinase with thrombospondin motifs 5
Names
ADAM metallopeptidase with thrombospondin type 1 motif, 5 (aggrecanase-2)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072420.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    27694103..27743444 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_531407.8 → XP_531407.3  A disintegrin and metalloproteinase with thrombospondin motifs 5

    UniProtKB/TrEMBL
    A0A2J8MQ55, A0A6D2WBZ3, H2QKW1, K7C8I8
    Related
    ENSPTRP00000023799.4
    Conserved Domains (4) summary
    smart00209
    Location:571 → 623
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:270 → 474
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01562
    Location:67 → 168
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:733 → 853
    ADAM_spacer1; ADAM-TS Spacer 1
Nucleotide Protein
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