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chchd6a coiled-coil-helix-coiled-coil-helix domain containing 6a [ Danio rerio (zebrafish) ]

Gene ID: 449542, updated on 27-Mar-2024

Summary

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Official Symbol
chchd6aprovided by ZNC
Official Full Name
coiled-coil-helix-coiled-coil-helix domain containing 6aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040930-2
See related
Ensembl:ENSDARG00000003206 AllianceGenome:ZFIN:ZDB-GENE-040930-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
chchd6; zeh0124; zgc:91802; hm:zeh0124
Summary
Predicted to be involved in cellular response to DNA damage stimulus and cristae formation. Predicted to be located in mitochondrial inner membrane. Predicted to be part of MICOS complex. Orthologous to human CHCHD6 (coiled-coil-helix-coiled-coil-helix domain containing 6). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 23
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (34047364..34185019)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (34120832..34258488)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene si:ch211-207e14.4 Neighboring gene seryl-tRNA synthetase 1 Neighboring gene plexin A1a Neighboring gene si:ch211-236h17.3 Neighboring gene solute carrier family 41 member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Decellularized zebrafish cardiac extracellular matrix induces mammalian heart regeneration. Chen WC, et al. Sci Adv, 2016 Nov. PMID 28138518, Free PMC Article
  2. Identification, characterization, and mapping of expressed sequence tags from an embryonic zebrafish heart cDNA library. Ton C, et al. Genome Res, 2000 Dec. PMID 11116087, Free PMC Article
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cristae formation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in inner mitochondrial membrane organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of MICOS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MICOS complex IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
MICOS complex subunit mic25a
Names
coiled-coil-helix-coiled-coil-helix domain-containing protein 6, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005584.1 → NP_001005584.1  MICOS complex subunit mic25a

    See identical proteins and their annotated locations for NP_001005584.1

    Status: PROVISIONAL

    Source sequence(s)
    BC082793
    UniProtKB/Swiss-Prot
    Q63ZW2
    Related
    ENSDARP00000116560.1, ENSDART00000143933.3
    Conserved Domains (2) summary
    pfam05300
    Location:16 → 187
    DUF737; Protein of unknown function (DUF737)
    pfam06747
    Location:195 → 229
    CHCH; CHCH domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    34047364..34185019
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005162311.3 → XP_005162368.1  MICOS complex subunit mic25a isoform X1

    UniProtKB/TrEMBL
    A0A2U3TWB2, A0A8M6Z3Q6
    Conserved Domains (2) summary
    pfam05300
    Location:16 → 195
    DUF737; Protein of unknown function (DUF737)
    pfam06747
    Location:203 → 237
    CHCH; CHCH domain

  2. XM_005162312.2 → XP_005162369.1  MICOS complex subunit mic25a isoform X2

    See identical proteins and their annotated locations for XP_005162369.1

    UniProtKB/Swiss-Prot
    Q63ZW2
    Conserved Domains (2) summary
    pfam05300
    Location:16 → 187
    DUF737; Protein of unknown function (DUF737)
    pfam06747
    Location:195 → 229
    CHCH; CHCH domain

  3. XM_017353546.2 → XP_017209035.1  MICOS complex subunit mic25a isoform X1

    UniProtKB/TrEMBL
    A0A2U3TWB2, A0A8M6Z3Q6
    Related
    ENSDARP00000143276.2, ENSDART00000176139.2
    Conserved Domains (2) summary
    pfam05300
    Location:16 → 195
    DUF737; Protein of unknown function (DUF737)
    pfam06747
    Location:203 → 237
    CHCH; CHCH domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63ZW2.1 GenPept UniProtKB/Swiss-Prot:Q63ZW2

Gene LinkOut

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