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pip5k1bb phosphatidylinositol-4-phosphate 5-kinase, type I, beta b [ Danio rerio (zebrafish) ]

Gene ID: 447840, updated on 11-Apr-2024

Summary

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Official Symbol
pip5k1bbprovided by ZNC
Official Full Name
phosphatidylinositol-4-phosphate 5-kinase, type I, beta bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040912-141
See related
Ensembl:ENSDARG00000006508 AllianceGenome:ZFIN:ZDB-GENE-040912-141
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:92316; wu:fj29b05; wu:fj93b05
Summary
Predicted to enable ATP binding activity and phosphatidylinositol phosphate kinase activity. Predicted to act upstream of or within phosphatidylinositol metabolic process and phosphorylation. Is expressed in blood island. Orthologous to human PIP5K1B (phosphatidylinositol-4-phosphate 5-kinase type 1 beta). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 8
Exon count:
16
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (11234168..11324138, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (11196463..11286433, complement)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene transcription activation suppressor family member 2 Neighboring gene unc-45 myosin chaperone B Neighboring gene frataxin Neighboring gene tight junction protein 2b (zona occludens 2)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Apical PtdIns(4,5)P(2) is required for ciliogenesis and suppression of polycystic kidney disease. Xu W, et al. FASEB J, 2019 Feb. PMID 30321068
  2. Two functional microRNA-126s repress a novel target gene p21-activated kinase 1 to regulate vascular integrity in zebrafish. Zou J, et al. Circ Res, 2011 Jan 21. PMID 21148433
  3. Consequences of lineage-specific gene loss on functional evolution of surviving paralogs: ALDH1A and retinoic acid signaling in vertebrate genomes. Cañestro C, et al. PLoS Genet, 2009 May. PMID 19478994, Free PMC Article
  4. Global analysis of the haematopoietic and endothelial transcriptome during zebrafish development. Cannon JE, et al. Mech Dev, 2013 Feb. PMID 23072875, Free PMC Article
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphatidylinositol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phosphatidylinositol 4-phosphate 5-kinase type-1 beta; phosphatidylinositol-4-phosphate 5-kinase type-1 beta
NP_001004579.1
XP_005166786.1
XP_009302056.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004579.1 → NP_001004579.1  phosphatidylinositol 4-phosphate 5-kinase type-1 beta

    See identical proteins and their annotated locations for NP_001004579.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081646
    UniProtKB/TrEMBL
    A0A8M1N244, Q66HW3
    Related
    ENSDARP00000009653.9, ENSDART00000008215.10
    Conserved Domains (1) summary
    smart00330
    Location:53 → 386
    PIPKc; Phosphatidylinositol phosphate kinases

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    11234168..11324138 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005166729.4 → XP_005166786.1  phosphatidylinositol-4-phosphate 5-kinase type-1 beta isoform X1

    See identical proteins and their annotated locations for XP_005166786.1

    UniProtKB/TrEMBL
    A0A8M3AUW9
    Conserved Domains (1) summary
    smart00330
    Location:53 → 386
    PIPKc; Phosphatidylinositol phosphate kinases

  2. XM_009303781.3 → XP_009302056.1  phosphatidylinositol-4-phosphate 5-kinase type-1 beta isoform X1

    See identical proteins and their annotated locations for XP_009302056.1

    UniProtKB/TrEMBL
    A0A8M3AUW9
    Conserved Domains (1) summary
    smart00330
    Location:53 → 386
    PIPKc; Phosphatidylinositol phosphate kinases
Nucleotide Protein Strain
Heading Accession and Version

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