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emp2 epithelial membrane protein 2 [ Danio rerio (zebrafish) ]

Gene ID: 445506, updated on 27-Mar-2024

Summary

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Official Symbol
emp2provided by ZNC
Official Full Name
epithelial membrane protein 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-040822-24
See related
Ensembl:ENSDARG00000044588 AllianceGenome:ZFIN:ZDB-GENE-040822-24
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
EMP-2; zgc:100935
Summary
Involved in regulation of glomerular filtration. Predicted to be located in cytoplasm and nucleus. Predicted to be active in plasma membrane. Is expressed in blood vessel; orbit; pectoral fin; pharyngeal arch; and pronephros. Human ortholog(s) of this gene implicated in nephrotic syndrome type 10. Orthologous to human EMP2 (epithelial membrane protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 3
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (27027750..27056180)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (26896923..26925328)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene class II, major histocompatibility complex, transactivator Neighboring gene nucleotide binding protein 1 (MinD homolog, E. coli) Neighboring gene uncharacterized LOC108182821 Neighboring gene activating transcription factor 7 interacting protein 2 Neighboring gene glutamate receptor, ionotropic, N-methyl D-aspartate 2A, a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Mutations in EMP2 cause childhood-onset nephrotic syndrome. Gee HY, et al. Am J Hum Genet, 2014 Jun 5. PMID 24814193, Free PMC Article
  2. Loss of Epithelial Membrane Protein 2 Aggravates Podocyte Injury via Upregulation of Caveolin-1. Wan X, et al. J Am Soc Nephrol, 2016 Apr. PMID 26264854, Free PMC Article
  3. A reverse genetic screen in the zebrafish identifies crb2b as a regulator of the glomerular filtration barrier. Ebarasi L, et al. Dev Biol, 2009 Oct 1. PMID 19393641
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
epithelial membrane protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004119.1 → NP_001004119.1  epithelial membrane protein 2

    See identical proteins and their annotated locations for NP_001004119.1

    Status: PROVISIONAL

    Source sequence(s)
    BC080211
    UniProtKB/TrEMBL
    Q68EL5
    Conserved Domains (1) summary
    cl21598
    Location:1 → 153
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    27027750..27056180
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021470381.1 → XP_021326056.1  epithelial membrane protein 2 isoform X1

    UniProtKB/Swiss-Prot
    F1QIK8
    UniProtKB/TrEMBL
    A0A8M9PUL4
    Related
    ENSDARP00000065494.4, ENSDART00000065495.5
    Conserved Domains (1) summary
    cl21598
    Location:1 → 154
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F1QIK8.2 GenPept UniProtKB/Swiss-Prot:F1QIK8

Gene LinkOut

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