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AR androgen receptor [ Ovis aries (sheep) ]

Gene ID: 443042, updated on 5-Mar-2024

Summary

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Gene symbol
AR
Gene description
androgen receptor
See related
EnsemblRapid:ENSOARG00020019886
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: X
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) X NC_056080.1 (60048753..60244465)

Chromosome X - NC_056080.1Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit 3-like Neighboring gene NADH-ubiquinone oxidoreductase chain 1-like Neighboring gene transfer RNA tyrosine (anticodon GUA) Neighboring gene oligophrenin 1 Neighboring gene small nucleolar RNA SNORA79 Neighboring gene uncharacterized LOC132658727 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056080.1 Chromosome X Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Postnatal changes in testicular development and androgen receptors immunolocalization in D'Man ram lambs. Boukenaoui N, et al. Folia Histochem Cytobiol, 2012 Apr 24. PMID 22532134
  2. Ontogeny of androgen receptor expression in the ovine fetal central nervous system and pituitary. Wood CE, et al. Neurosci Lett, 2008 Jul 11. PMID 18514409, Free PMC Article
  3. Expression of androgen receptor and estrogen receptor-alpha in the developing pituitary gland of male sheep lamb. Huang LB, et al. Anim Reprod Sci, 2011 Sep. PMID 21880440
  4. Expression and distribution of P450-aromatase in the ovine hypothalamus at different stages of fetal development. Mura A, et al. Neuro Endocrinol Lett, 2010. PMID 21173749
  5. Ontogeny of estrogen receptor alpha, estrogen receptor beta and androgen receptor, and their co-localization with Islet-1 in the dorsal root ganglia of sheep fetuses during gestation. Luo H, et al. Histochem Cell Biol, 2008 Apr. PMID 18204852

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. androgen receptors detected with immunohistochemistry were located in the nuclei and cytoplasm of adenohypophysis cells, and only in nuclei of testis cells (Leydig, Sertoli, peritubular myoid and germ cells)
    Title: Postnatal changes in testicular development and androgen receptors immunolocalization in D'Man ram lambs.
  2. Both AR and ERalpha are important in regulation of secretary function of anterior pituitary in sheep lamb.
    Title: Expression of androgen receptor and estrogen receptor-alpha in the developing pituitary gland of male sheep lamb.
  3. The highest aromatase and androgen receptor amounts were observed at 35GD and 55GD, when aromatase was more abundant in females than in males
    Title: Expression and distribution of P450-aromatase in the ovine hypothalamus at different stages of fetal development.
  4. expression of androgen receptor occurs in fetal brain and pituitary, and that the abundance of the AR is ontogenetically regulated.
    Title: Ontogeny of androgen receptor expression in the ovine fetal central nervous system and pituitary.
  5. Ontogeny of AR and its co-localization with Islet-1 in the dorsal root ganglia of sheep fetuses during gestation is reported.
    Title: Ontogeny of estrogen receptor alpha, estrogen receptor beta and androgen receptor, and their co-localization with Islet-1 in the dorsal root ganglia of sheep fetuses during gestation.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables steroid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in androgen receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in male gonad development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
androgen receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308584.1 → NP_001295513.1  androgen receptor

    See identical proteins and their annotated locations for NP_001295513.1

    Status: PROVISIONAL

    Source sequence(s)
    KF227907
    UniProtKB/TrEMBL
    A0A6P9FR47, A0A835ZMY4, S5U7M4
    Related
    ENSOARP00020025428.1, ENSOART00020030780.2
    Conserved Domains (3) summary
    cd07073
    Location:643 → 888
    NR_LBD_AR; Ligand binding domain of the nuclear receptor androgen receptor, ligand activated transcription regulator
    cd07173
    Location:525 → 606
    NR_DBD_AR; DNA-binding domain of androgen receptor (AR) is composed of two C4-type zinc fingers
    pfam02166
    Location:6 → 429
    Androgen_recep; Androgen receptor

RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UI_Ramb_v3.0 Primary Assembly

Genomic

  1. NC_056080.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Range
    60048753..60244465
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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