U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

egln1b egl-9 family hypoxia-inducible factor 1b [ Danio rerio (zebrafish) ]

Gene ID: 436868, updated on 16-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
egln1bprovided by ZNC
Official Full Name
egl-9 family hypoxia-inducible factor 1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040718-338
See related
Ensembl:ENSDARG00000004632 AllianceGenome:ZFIN:ZDB-GENE-040718-338
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
egln1; fk45e02; zgc:92314; wu:fk45e02
Summary
Predicted to enable ferrous iron binding activity and peptidyl-proline 4-dioxygenase activity. Predicted to be involved in cellular response to hypoxia and peptidyl-proline hydroxylation to 4-hydroxy-L-proline. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in familial erythrocytosis 3; polycythemia; and renal cell carcinoma. Orthologous to human EGLN1 (egl-9 family hypoxia inducible factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 11
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (31558112..31603506)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (31295147..31340446)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene si:dkey-238i5.2 Neighboring gene signal-induced proliferation-associated 1 like 2 Neighboring gene proline and serine-rich protein 1-like Neighboring gene zgc:162816 Neighboring gene family with sequence similarity 126 member B

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Anti-Hypoxic Molecular Mechanisms of Rhodiola crenulata Extract in Zebrafish as Revealed by Metabonomics. Ma Y, et al. Front Pharmacol, 2019. PMID 31780949, Free PMC Article
  2. TET is targeted for proteasomal degradation by the PHD-pVHL pathway to reduce DNA hydroxymethylation. Fan S, et al. J Biol Chem, 2020 Nov 27. PMID 32963106, Free PMC Article
  3. Deficiency of a transmembrane prolyl 4-hydroxylase in the zebrafish leads to basement membrane defects and compromised kidney function. Hyvärinen J, et al. J Biol Chem, 2010 Dec 31. PMID 20952382, Free PMC Article
  4. Zebrafish mutants in the von Hippel-Lindau tumor suppressor display a hypoxic response and recapitulate key aspects of Chuvash polycythemia. van Rooijen E, et al. Blood, 2009 Jun 18. PMID 19304954
  5. A Toolbox for Efficient Proximity-Dependent Biotinylation in Zebrafish Embryos. Rosenthal SM, et al. Mol Cell Proteomics, 2021. PMID 34332124, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Zebrafish mutants in egln1 display a hypoxic response and develop polycythemia.
    Title: Zebrafish mutants in egln1 display a hypoxic response and develop polycythemia.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables L-ascorbic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables ferrous iron binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hypoxia-inducible factor-proline dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
enables peptidyl-proline 4-dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to hypoxia IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-proline hydroxylation to 4-hydroxy-L-proline IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
egl nine homolog 1; egl nine homolog 1b
Names
Hif-p4h-2
NP_001002595.2
XP_021335268.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002595.2 → NP_001002595.2  egl nine homolog 1b

    Status: VALIDATED

    Source sequence(s)
    BC076001
    UniProtKB/TrEMBL
    A0A8M1N0S3, F6P6J7, Q6DHH3
    Related
    ENSDARP00000005048.7, ENSDART00000024296.8
    Conserved Domains (2) summary
    smart00702
    Location:152 → 326
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    pfam01753
    Location:18 → 55
    zf-MYND; MYND finger

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    31558112..31603506
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021479593.1 → XP_021335268.1  egl nine homolog 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q756, Q6DHH3
    Conserved Domains (2) summary
    smart00702
    Location:152 → 286
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    pfam01753
    Location:18 → 55
    zf-MYND; MYND finger
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous