U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

syt1a synaptotagmin Ia [ Danio rerio (zebrafish) ]

Gene ID: 436736, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
syt1aprovided by ZNC
Official Full Name
synaptotagmin Iaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040718-165
See related
Ensembl:ENSDARG00000030614 AllianceGenome:ZFIN:ZDB-GENE-040718-165
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
syt1; zgc:92899; wu:fj41c01; wu:fk56d05
Summary
Predicted to enable several functions, including calcium ion binding activity; phospholipid binding activity; and syntaxin binding activity. Predicted to be involved in cellular response to calcium ion; regulation of secretion by cell; and synaptic vesicle cycle. Predicted to act upstream of or within neurotransmitter secretion. Predicted to be located in chromaffin granule membrane and synaptic vesicle. Predicted to be integral component of membrane. Predicted to be active in axon; plasma membrane; and secretory vesicle. Is expressed in brain; epiphysis; olfactory bulb; and retinal ganglion cell layer. Orthologous to human SYT1 (synaptotagmin 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 4
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (21040559..21315406)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (21319537..21594424)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene neuron navigator 3 Neighboring gene uncharacterized LOC101884898 Neighboring gene PRKC, apoptosis, WT1, regulator Neighboring gene protein phosphatase 1, regulatory subunit 12A

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Neuronal Ndrg4 Is Essential for Nodes of Ranvier Organization in Zebrafish. Fontenas L, et al. PLoS Genet, 2016 Nov. PMID 27902705, Free PMC Article
  2. Characterization of Hspb8 in Zebrafish. Dubińska-Magiera M, et al. Cells, 2020 Jun 26. PMID 32604890, Free PMC Article
  3. Acrylamide acute neurotoxicity in adult zebrafish. Faria M, et al. Sci Rep, 2018 May 21. PMID 29784925, Free PMC Article
  4. Modelling acrylamide acute neurotoxicity in zebrafish larvae. Prats E, et al. Sci Rep, 2017 Oct 24. PMID 29066856, Free PMC Article
  5. Androgenic activation, impairment of the monoaminergic system and altered behavior in zebrafish larvae exposed to environmental concentrations of fenitrothion. Faria M, et al. Sci Total Environ, 2021 Jun 25. PMID 33621872

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in calcium ion-regulated exocytosis of neurotransmitter IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromaffin granule membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in dense core granule IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in exocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
synaptotagmin-1; synaptotagmin-1a
Names
synaptotagmin I

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001327829.1 → NP_001314758.1  synaptotagmin-1a

    Status: VALIDATED

    Source sequence(s)
    BX511172, BX511298, BX537146
    UniProtKB/TrEMBL
    A0A8M2BC70, Q5TZ27
    Related
    ENSDARP00000141860.1, ENSDART00000169764.2
    Conserved Domains (2) summary
    cd08385
    Location:139 → 261
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:270 → 405
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    21040559..21315406
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009300373.3 → XP_009298648.1  synaptotagmin-1 isoform X2

    See identical proteins and their annotated locations for XP_009298648.1

    UniProtKB/TrEMBL
    A0A8M2BC44
    Conserved Domains (2) summary
    cd08385
    Location:136 → 258
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:267 → 402
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1

  2. XM_017354995.2 → XP_017210484.1  synaptotagmin-1 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BC70, Q5TZ27
    Conserved Domains (2) summary
    cd08385
    Location:139 → 261
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:270 → 405
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1

  3. XM_017354996.2 → XP_017210485.1  synaptotagmin-1 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BC70, Q5TZ27
    Conserved Domains (2) summary
    cd08385
    Location:139 → 261
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:270 → 405
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1

  4. XM_005164872.4 → XP_005164929.1  synaptotagmin-1 isoform X1

    See identical proteins and their annotated locations for XP_005164929.1

    UniProtKB/TrEMBL
    A0A8M2BC70, Q5TZ27
    Related
    ENSDARP00000041860.4, ENSDART00000041861.5
    Conserved Domains (2) summary
    cd08385
    Location:139 → 261
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:270 → 405
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1

  5. XM_005164874.4 → XP_005164931.1  synaptotagmin-1 isoform X2

    See identical proteins and their annotated locations for XP_005164931.1

    UniProtKB/TrEMBL
    A0A8M2BC44
    Conserved Domains (2) summary
    cd08385
    Location:136 → 258
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:267 → 402
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001002463.1: Suppressed sequence

    Description
    NM_001002463.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.