syt5a synaptotagmin Va [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: syt5aprovided by ZNC
Official Full Name: synaptotagmin Vaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040718-110
See related: Ensembl:ENSDARG00000037941 AllianceGenome:ZFIN:ZDB-GENE-040718-110
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: syt5; zgc:92682
Summary: Predicted to enable several functions, including calcium ion binding activity; phospholipid binding activity; and syntaxin binding activity. Predicted to be involved in cellular response to calcium ion; regulation of secretion by cell; and synaptic vesicle cycle. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in axon; plasma membrane; and secretory vesicle. Is expressed in epiphysis; midbrain; and retina. Orthologous to human SYT5 (synaptotagmin 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (32142396..32151163)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (32010689..32019453)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables clathrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylserine binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in calcium ion-regulated exocytosis of neurotransmitter	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle endocytosis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
is_active_in dense core granule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in exocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synaptic vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: synaptotagmin Va

Names: synaptotagmin V

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001103137.1 → NP_001096607.1 synaptotagmin Va

See identical proteins and their annotated locations for NP_001096607.1

Status: PROVISIONAL

Source sequence(s)

BC152174

UniProtKB/TrEMBL

A7MCG9

Related

ENSDARP00000122114.1, ENSDART00000133035.3

Conserved Domains (2) summary

cd08385
Location:128 → 246

C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10

cd08402
Location:256 → 391

C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007114.7 Reference GRCz11 Primary Assembly

Range

32142396..32151163

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009299530.3 → XP_009297805.1 synaptotagmin Va isoform X1

UniProtKB/TrEMBL

A0A8M3AQM3

Conserved Domains (2) summary

cd08385
Location:128 → 246

C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10

cd08402
Location:256 → 391

C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1