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aldh6a1 aldehyde dehydrogenase 6 family, member A1 [ Danio rerio (zebrafish) ]

Gene ID: 436647, updated on 14-Apr-2024

Summary

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Official Symbol
aldh6a1provided by ZNC
Official Full Name
aldehyde dehydrogenase 6 family, member A1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9192
See related
Ensembl:ENSDARG00000053485 AllianceGenome:ZFIN:ZDB-GENE-030131-9192
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb850; zgc:92082; wu:fb03a04
Summary
Predicted to enable malonate-semialdehyde dehydrogenase (acetylating) activity and methylmalonate-semialdehyde dehydrogenase (acylating) activity. Predicted to be involved in thymine catabolic process and valine catabolic process. Predicted to be active in mitochondrion. Is expressed in several structures, including alar plate midbrain region; digestive system; midbrain; musculature system; and ventricular zone. Orthologous to human ALDH6A1 (aldehyde dehydrogenase 6 family member A1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See aldh6a1 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (45073179..45104627, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (44959414..44990862, complement)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene coenzyme Q6 monooxygenase Neighboring gene ectonucleoside triphosphate diphosphohydrolase 5a Neighboring gene zgc:163014 Neighboring gene glutathione S-transferase zeta 1 Neighboring gene transmembrane p24 trafficking protein 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Gender-specific proteomic responses in zebrafish liver following exposure to a selected mixture of brominated flame retardants. Kling P, et al. Ecotoxicol Environ Saf, 2008 Oct. PMID 18258299
  2. An integrated transcriptomic and proteomic approach characterizing estrogenic and metabolic effects of 17 alpha-ethinylestradiol in zebrafish (Danio rerio). De Wit M, et al. Gen Comp Endocrinol, 2010 Jun 1. PMID 20227414
  3. ALDH2 mediates 5-nitrofuran activity in multiple species. Zhou L, et al. Chem Biol, 2012 Jul 27. PMID 22840776, Free PMC Article
  4. Aldh2 is a lineage-specific metabolic gatekeeper in melanocyte stem cells. Brunsdon H, et al. Development, 2022 May 15. PMID 35485397, Free PMC Article
  5. A DEAB-sensitive aldehyde dehydrogenase regulates hematopoietic stem and progenitor cells development during primitive hematopoiesis in zebrafish embryos. Ma AC, et al. Leukemia, 2010 Dec. PMID 20927131

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in thymine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in valine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
Names
mitochondrial acylating methylmalonate-semialdehyde dehydrogenase
NP_001002374.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002374.2 → NP_001002374.1  methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial

    See identical proteins and their annotated locations for NP_001002374.1

    Status: VALIDATED

    Source sequence(s)
    BC075883, FO704844
    UniProtKB/TrEMBL
    A0A8M1N0E4, Q6DHT4
    Related
    ENSDARP00000070002.4, ENSDART00000075520.6
    Conserved Domains (1) summary
    cd07085
    Location:30 → 506
    ALDH_F6_MMSDH; Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    45073179..45104627 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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