CD200 CD200 molecule [Homo sapiens (human)] - Gene

Summary

Official Symbol: CD200provided by HGNC
Official Full Name: CD200 moleculeprovided by HGNC
Primary source: HGNC:HGNC:7203
See related: Ensembl:ENSG00000091972 MIM:155970; AllianceGenome:HGNC:7203
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MRC; MOX1; MOX2; OX-2
Summary: This gene encodes a type I membrane glycoprotein containing two extracellular immunoglobulin domains, a transmembrane and a cytoplasmic domain. This gene is expressed by various cell types, including B cells, a subset of T cells, thymocytes, endothelial cells, and neurons. The encoded protein plays an important role in immunosuppression and regulation of anti-tumor activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Expression: Broad expression in brain (RPKM 5.4), placenta (RPKM 3.5) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3q13.2

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (112332573..112362812)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (115053635..115083861)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (112051420..112081659)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CD200 genotype is associated with clinical outcome of patients with multiple myeloma.
Title: CD200 genotype is associated with clinical outcome of patients with multiple myeloma.
Exploiting the CD200-CD200R immune checkpoint axis in multiple myeloma to enhance CAR T-cell therapy.
Title: Exploiting the CD200-CD200R immune checkpoint axis in multiple myeloma to enhance CAR T-cell therapy.
Integrating TSPO PET imaging and transcriptomics to unveil the role of neuroinflammation and amyloid-beta deposition in Alzheimer's disease.
Title: Integrating TSPO PET imaging and transcriptomics to unveil the role of neuroinflammation and amyloid-β deposition in Alzheimer's disease.
Emerging Immune Checkpoint Molecules on Cancer Cells: CD24 and CD200.
Title: Emerging Immune Checkpoint Molecules on Cancer Cells: CD24 and CD200.
The immunoregulatory protein CD200 as a potentially lucrative yet elusive target for cancer therapy.
Title: The immunoregulatory protein CD200 as a potentially lucrative yet elusive target for cancer therapy.
The Role of CD200-CD200 Receptor in Human Blood and Lymphatic Endothelial Cells in the Regulation of Skin Tissue Inflammation.
Title: The Role of CD200-CD200 Receptor in Human Blood and Lymphatic Endothelial Cells in the Regulation of Skin Tissue Inflammation.
The CD200-CD200R Axis Promotes Squamous Cell Carcinoma Metastasis via Regulation of Cathepsin K.
Title: The CD200-CD200R Axis Promotes Squamous Cell Carcinoma Metastasis via Regulation of Cathepsin K.
Association of CD200 expression in paternal lymphocytes with female Th1/Th2 balance and pregnancy establishment at immunotherapy of recurrent spontaneous abortion.
Title: Association of CD200 expression in paternal lymphocytes with female Th1/Th2 balance and pregnancy establishment at immunotherapy of recurrent spontaneous abortion.
CD200 expression in hematopoietic neoplasms: Beyond a marker for diagnosis of B-cell neoplasms.
Title: CD200 expression in hematopoietic neoplasms: Beyond a marker for diagnosis of B-cell neoplasms.
Impact of Concomitant Aberrant CD200 and BCL2 Overexpression on Outcome of Acute Myeloid Leukemia: A Cohort Study from a Single Center
Title: Impact of Concomitant Aberrant CD200 and BCL2 Overexpression on Outcome of Acute Myeloid Leukemia: A Cohort Study from a Single Center.

Submit: New GeneRIF Correction See all GeneRIFs (133)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-77191 (e-PCR)
- UniSTS:43527

GDB:181218 (e-PCR)
- UniSTS:155186

D3S2874E (e-PCR)
- UniSTS:150878

WI-20298 (e-PCR)
- UniSTS:65895

D3S2924E (e-PCR)
- UniSTS:150908

SHGC-36351 (e-PCR)
- UniSTS:83389

RH25443 (e-PCR)
- UniSTS:86238

D3S3951 (e-PCR)
- UniSTS:57072

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cell-cell adhesion mediator activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycosylated region protein binding	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding involved in heterotypic cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in heterotypic cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in heterotypic cell-cell adhesion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in heterotypic cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of NF-kappaB transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of T cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of interleukin-6 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of leukocyte activation	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of macrophage activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of macrophage migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of matrix metallopeptidase secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neuroinflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of neuroinflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of CREB transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of arginase activity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein-glutamine gamma-glutamyltransferase activity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transforming growth factor beta production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of immune response	IEA Inferred from Electronic Annotation more info
involved_in regulation of neuroinflammatory response	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
located_in cell surface	TAS Traceable Author Statement more info	PubMed
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
located_in neuron projection	ISS Inferred from Sequence or Structural Similarity more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: OX-2 membrane glycoprotein

Names: CD200 antigen; antigen identified by monoclonal antibody MRC OX-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004196.4 → NP_001004196.2 OX-2 membrane glycoprotein isoform b

See identical proteins and their annotated locations for NP_001004196.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) includes an alternate in-frame exon in the 5' coding region, compared to variant 1, that results in an isoform (b) with a longer N-terminus, compared to isoform a.

Source sequence(s)

AC112487, AK297194, AL832529

Consensus CDS

CCDS33818.1

UniProtKB/Swiss-Prot

P41217

Related

ENSP00000420298.1, ENST00000473539.5

Conserved Domains (2) summary

cd05846
Location:69 → 165

Ig1_MRC-OX-2_like; First immunoglobulin (Ig) domain of rat MRC OX-2 antigen (also known as CD200) and similar proteins

cl11960
Location:181 → 253

Ig; Immunoglobulin domain
NM_001318826.2 → NP_001305755.1 OX-2 membrane glycoprotein isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate splice site in an internal exon resulting in a distinct 5' UTR and translation initiation at an alternate start codon, compared to variant 1. The encoded isoform (c) is shorter and has a distinct N-terminus, compared to isoform a. Both variants 3 and 5 encode the same protein (isoform c).

Source sequence(s)

AC112487, AK312563, AL832529, DA773259

Conserved Domains (1) summary

cl11960
Location:43 → 112

Ig; Immunoglobulin domain
NM_001318828.2 → NP_001305757.1 OX-2 membrane glycoprotein isoform d

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus, compared to isoform a.

Source sequence(s)

AC112487, AK293399, AL832529, BC022522, DA773259

Consensus CDS

CCDS82819.1

UniProtKB/TrEMBL

B4DDZ6, F8W7G1

Related

ENSP00000373179.3, ENST00000383681.7

Conserved Domains (2) summary

cd00096
Location:9 → 13

Ig; Ig strand C" [structural motif]

cl11960
Location:1 → 65

Ig; Immunoglobulin domain
NM_001318830.2 → NP_001305759.1 OX-2 membrane glycoprotein isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at an alternate start codon and result in a shorter isoform (c) with a distinct N-terminus, compared to isoform a. Both variants 3 and 5 encode the same protein (isoform c).

Source sequence(s)

AK129797, AL832529, DA773259

Conserved Domains (1) summary

cl11960
Location:43 → 112

Ig; Immunoglobulin domain
NM_001365851.2 → NP_001352780.1 OX-2 membrane glycoprotein isoform e precursor

Status: REVIEWED

Source sequence(s)

AC112487

UniProtKB/Swiss-Prot

B3KQI1, B4DLW9, D3DN65, P41217, Q6J2Q6, Q6PIQ4, Q8TB85, Q9H3J3

Conserved Domains (2) summary

cd05846
Location:44 → 138

Ig1_MRC-OX-2_like; First immunoglobulin (Ig) domain of rat MRC OX-2 antigen (also known as CD200) and similar domains

cl11960
Location:159 → 228

Ig; Immunoglobulin domain
NM_001365852.1 → NP_001352781.1 OX-2 membrane glycoprotein isoform f precursor

Status: REVIEWED

Source sequence(s)

AC112487

Conserved Domains (3) summary

cd00096
Location:160 → 166

Ig; Ig strand C [structural motif]

cd05846
Location:25 → 132

IgV_1_MRC-OX-2_like; First immunoglobulin (Ig) variable (V) domain of rat MRC OX-2 antigen, and similar domains

cl11960
Location:152 → 223

Ig; Immunoglobulin domain
NM_001365853.1 → NP_001352782.1 OX-2 membrane glycoprotein isoform f precursor

Status: REVIEWED

Source sequence(s)

AC112487

Conserved Domains (3) summary

cd00096
Location:160 → 166

Ig; Ig strand C [structural motif]

cd05846
Location:25 → 132

IgV_1_MRC-OX-2_like; First immunoglobulin (Ig) variable (V) domain of rat MRC OX-2 antigen, and similar domains

cl11960
Location:152 → 223

Ig; Immunoglobulin domain
NM_001365854.1 → NP_001352783.1 OX-2 membrane glycoprotein isoform f precursor

Status: REVIEWED

Source sequence(s)

AC112487

Conserved Domains (3) summary

cd00096
Location:160 → 166

Ig; Ig strand C [structural motif]

cd05846
Location:25 → 132

IgV_1_MRC-OX-2_like; First immunoglobulin (Ig) variable (V) domain of rat MRC OX-2 antigen, and similar domains

cl11960
Location:152 → 223

Ig; Immunoglobulin domain
NM_001365855.1 → NP_001352784.1 OX-2 membrane glycoprotein isoform c

Status: REVIEWED

Source sequence(s)

AC112487

Conserved Domains (1) summary

cl11960
Location:43 → 112

Ig; Immunoglobulin domain
NM_005944.7 → NP_005935.4 OX-2 membrane glycoprotein isoform a precursor

See identical proteins and their annotated locations for NP_005935.4

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform a.

Source sequence(s)

AL832529, BC022522, DA544134

Consensus CDS

CCDS2965.1

UniProtKB/Swiss-Prot

P41217

Related

ENSP00000312766.8, ENST00000315711.12

Conserved Domains (2) summary

cd05846
Location:44 → 140

Ig1_MRC-OX-2_like; First immunoglobulin (Ig) domain of rat MRC OX-2 antigen (also known as CD200) and similar proteins

cl11960
Location:156 → 228

Ig; Immunoglobulin domain

RNA

NR_158642.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC112487

Related

ENST00000478595.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p14 Primary Assembly

Range

112332573..112362812

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060927.1 Alternate T2T-CHM13v2.0

Range

115053635..115083861

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001004197.1: Suppressed sequence

Description

NM_001004197.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.