Cmpk Cytidine/uridine monophosphate kinase 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Cmpkprovided by FlyBase
Official Full Name: Cytidine/uridine monophosphate kinase 1provided by FlyBase
Primary source: FLYBASE:FBgn0028833
Locus tag: Dmel_CG6092
See related: AllianceGenome:FB:FBgn0028833
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0118547.320; CG6092; dak1; Dak1; Dak1L; Dm.UMP-CMP kinase; Dmel\CG6092; UMP-CMPK
Summary: Enables cytidylate kinase activity and uridylate kinase activity. Predicted to be involved in 'de novo' pyrimidine nucleobase biosynthetic process; CDP biosynthetic process; and UDP biosynthetic process. Predicted to be active in cytoplasm and nucleus. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human CMPK1 (cytidine/uridine monophosphate kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (26054237..26055438, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (21879959..21881160, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables UMP kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables UMP/dUMP kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables UMP/dUMP kinase activity	IEA Inferred from Electronic Annotation more info
enables cytidylate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytidylate kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables cytidylate kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleobase-containing compound kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 'de novo' pyrimidine nucleobase biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in 'de novo' pyrimidine nucleobase biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in CDP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in UDP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleobase-containing compound metabolic process	IEA Inferred from Electronic Annotation more info
involved_in nucleobase-containing compound metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in pyrimidine nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

NP_651456.1

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The following sections contain reference sequences that belong to a specific genome build. Explain