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Adsl Adenylosuccinate lyase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42051, updated on 26-Apr-2024

Summary

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Official Symbol
Adslprovided by FlyBase
Official Full Name
Adenylosuccinate lyaseprovided by FlyBase
Primary source
FLYBASE:FBgn0038467
Locus tag
Dmel_CG3590
See related
AllianceGenome:FB:FBgn0038467
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AdSL; CG3590; Dmel\CG3590
Summary
Predicted to enable (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity and N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity. Predicted to be involved in 'de novo' AMP biosynthetic process. Predicted to be active in cytosol. Is expressed in adult head. Human ortholog(s) of this gene implicated in adenylosuccinase lyase deficiency. Orthologous to human ADSL (adenylosuccinate lyase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
89E8-89E8; 3-59 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17018780..17021120, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12844502..12846842, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Immune-regulated catalase Neighboring gene uncharacterized protein Neighboring gene Peroxidase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PRPS-Associated Disorders and the Drosophila Model of Arts Syndrome. Delos Santos K, et al. Int J Mol Sci, 2020 Jul 8. PMID 32650483, Free PMC Article
  2. Adenosine nucleotide biosynthesis and AMPK regulate adult life span and mediate the longevity benefit of caloric restriction in flies. Stenesen D, et al. Cell Metab, 2013 Jan 8. PMID 23312286, Free PMC Article
  3. Global stable-isotope tracing metabolomics reveals system-wide metabolic alternations in aging Drosophila. Wang R, et al. Nat Commun, 2022 Jun 20. PMID 35725845, Free PMC Article
  4. Habituation Learning Is a Widely Affected Mechanism in Drosophila Models of Intellectual Disability and Autism Spectrum Disorders. Fenckova M, et al. Biol Psychiatry, 2019 Aug 15. PMID 31272685, Free PMC Article
  5. Time-restricted feeding promotes muscle function through purine cycle and AMPK signaling in Drosophila obesity models. Livelo C, et al. Nat Commun, 2023 Feb 21. PMID 36810287, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity IEA
Inferred from Electronic Annotation
more info
  
enables N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 'de novo' AMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in purine nucleotide metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in purine ribonucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
adenylosuccinate lyase
Names
Adsl-PA
CG3590-PA
NP_650586.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    17018780..17021120 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142329.4 → NP_650586.2  adenylosuccinate lyase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650586.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95SP9, Q9VEP6
    Related
    FBpp0082816
    Conserved Domains (2) summary
    cd03302
    Location:12 → 447
    Adenylsuccinate_lyase_2; Adenylsuccinate lyase (ASL)_subgroup 2
    COG0015
    Location:12 → 458
    PurB; Adenylosuccinate lyase [Nucleotide transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95SP9 Q95SP9
Q9VEP6 Q9VEP6

Gene LinkOut

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