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CDH2 cadherin 2 [ Gallus gallus (chicken) ]

Gene ID: 414745, updated on 3-Apr-2024

Summary

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Symbol
CDH2provided by CGNC
Full Name
cadherin 2provided by CGNC
Primary source
CGNC:11259
See related
Ensembl:ENSGALG00010005621
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
cadherin-2
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
17
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (104411911..104526394, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (104470744..104585166, complement)

Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC769098 Neighboring gene uncharacterized LOC124417748 Neighboring gene uncharacterized LOC112531839 Neighboring gene uncharacterized LOC101749116

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Effects of N-cadherin on neuronal migration during chicken optic tectum development. Yang C, et al. Histochem Cell Biol, 2019 Mar. PMID 30250974
  2. N-cadherin locks left-right asymmetry by ending the leftward movement of Hensen's node cells. Mendes RV, et al. Dev Cell, 2014 Aug 11. PMID 25117685
  3. Identification of a novel intermediate filament-linked N-cadherin/gamma-catenin complex involved in the establishment of the cytoarchitecture of differentiated lens fiber cells. Leonard M, et al. Dev Biol, 2008 Jul 15. PMID 18514185, Free PMC Article
  4. Dynamics of ligand-induced, Rac1-dependent anchoring of cadherins to the actin cytoskeleton. Lambert M, et al. J Cell Biol, 2002 Apr 29. PMID 11970959, Free PMC Article
  5. Isolation and characterization of the promoter region of the chicken N-cadherin gene. Li B, et al. Gene, 1997 May 20. PMID 9210582

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Neural crest cell-placodal neuron interactions are mediated by Cadherin-7 and N-cadherin during early chick trigeminal ganglion assembly.
    Title: Neural crest cell-placodal neuron interactions are mediated by Cadherin-7 and N-cadherin during early chick trigeminal ganglion assembly.
  2. The results reveal that the knockdown of N-cadherin mainly affects the length of axons and formation of multipolar neurons in the development of the chicken optic tectum, which eventually results in the inhibition of neuronal migration.
    Title: Effects of N-cadherin on neuronal migration during chicken optic tectum development.
  3. we demonstrate that the balance of Ecad and Ncad is dependent upon the availability of beta-catenin proteins, and that alteration of either classical cadherin modifies the proportions of the neural crest and neuroectodermal cells that are specified
    Title: A catenin-dependent balance between N-cadherin and E-cadherin controls neuroectodermal cell fate choices.
  4. in chicken and mouse embryos, PAPC expression is tightly regulated by the clock and wavefront system in the posterior PSM and exhibits a striking complementary pattern to N-cadherin
    Title: PAPC couples the segmentation clock to somite morphogenesis by regulating N-cadherin-dependent adhesion.
  5. N-cadherin stops the leftward cell movements and that this termination is an essential step in the establishment of left-right asymmetry
    Title: N-cadherin locks left-right asymmetry by ending the leftward movement of Hensen's node cells.
  6. These results identified the apical endfoot as the central site of active Notch signaling to securely prohibit inappropriate differentiation of neural progenitors.
    Title: Cadherin-based adhesions in the apical endfoot are required for active Notch signaling to control neurogenesis in vertebrates.
  7. Inhibition of ADAM10 can inhibit Pax6 expression and N-cadherin ectodomain shedding in retinal cells, possibly affecting neurite outgrowth and ganglion cell differentiation.
    Title: ADAM10 mediates N-cadherin ectodomain shedding during retinal ganglion cell differentiation in primary cultured retinal cells from the developing chick retina.
  8. Phosphoinositide 3-kinase and Rac polarization depend specifically on the N-cadherin-p120 catenin complex, whereas myosin II light chain and actin filament polarization depend on the N-cadherin-beta-catenin complex.
    Title: N-cadherin regulates spatially polarized signals through distinct p120ctn and β-catenin-dependent signalling pathways.
  9. These findings suggest that ligand-selective mechanotransduction may supersede differences in cadherin binding affinities in regulating intercellular contacts.
    Title: Cadherin-dependent mechanotransduction depends on ligand identity but not affinity.
  10. overexpressing N-cadherin on axons prevents the formation of the lateral funiculus and the spinocerebellar tract
    Title: Axon sorting within the spinal cord marginal zone via Robo-mediated inhibition of N-cadherin controls spinocerebellar tract formation.
Submit: New GeneRIF Correction See all GeneRIFs (28)

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cadherin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in adherens junction organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in blood vessel morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in brain development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell-cell junction assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of axonogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of synaptic transmission, glutamatergic IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in synapse assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in apical part of cell IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of catenin complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in intercalated disc IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in postsynaptic specialization membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in presynaptic active zone membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cadherin-2
Names
N-cadherin
cadherin 2, type 1, N-cadherin (neuronal)
neural cadherin
neural calcium-dependent cell adhesion molecule

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001615.2 → NP_001001615.1  cadherin-2 precursor

    See identical proteins and their annotated locations for NP_001001615.1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000043, X07277
    UniProtKB/Swiss-Prot
    P10288, Q90630
    UniProtKB/TrEMBL
    A0A8V0XQ13
    Related
    ENSGALP00010007990.1, ENSGALT00010013463.1
    Conserved Domains (5) summary
    cd11304
    Location:278 → 383
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam00028
    Location:615 → 707
    Cadherin; Cadherin domain
    pfam01049
    Location:765 → 908
    Cadherin_C; Cadherin cytoplasmic region
    pfam08758
    Location:36 → 126
    Cadherin_pro; Cadherin prodomain like
    cl09101
    Location:168 → 268
    E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    104411911..104526394 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040677263.2 → XP_040533197.1  cadherin-2 isoform X1

    UniProtKB/TrEMBL
    A0A3Q2UGT3, A0A8V0XQ13
    Related
    ENSGALP00010007983.1, ENSGALT00010013455.1
    Conserved Domains (3) summary
    cd11304
    Location:216 → 321
    Cadherin_repeat; Cadherin tandem repeat domain
    smart01055
    Location:2 → 62
    Cadherin_pro; Cadherin prodomain like
    cl28889
    Location:106 → 206
    CA_like; Cadherin repeat-like domain

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    104470744..104585166 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046910581.1 → XP_046766537.1  cadherin-2 isoform X1

    UniProtKB/TrEMBL
    A0A3Q2UGT3

  2. XM_046910580.1 → XP_046766536.1  cadherin-2 isoform X2

    UniProtKB/TrEMBL
    A0A3Q2UGT3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P10288.1 GenPept UniProtKB/Swiss-Prot:P10288

Gene LinkOut

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