Ak3 Adenylate kinase 3 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ak3provided by FlyBase
Official Full Name: Adenylate kinase 3provided by FlyBase
Primary source: FLYBASE:FBgn0042094
Locus tag: Dmel_CG6612
See related: AllianceGenome:FB:FBgn0042094
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Adk3; AK3; bs12h03.y1; CG6612; Dak3; DAK3; Dmel\CG6612
Summary: Enables adenylate kinase activity. Predicted to be involved in ADP biosynthetic process; AMP metabolic process; and nucleoside triphosphate biosynthetic process. Located in mitochondrion. Is expressed in adult head; adult heart; and spermatozoon. Orthologous to several human genes including AK3 (adenylate kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 86C7-86C7; 3-50 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (10887345..10889588, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (6713067..6715310, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables adenylate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenylate kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables adenylate kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleobase-containing compound kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleoside triphosphate adenylate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphotransferase activity, phosphate group as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ADP biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in AMP metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleobase-containing compound metabolic process	IEA Inferred from Electronic Annotation more info
involved_in nucleoside triphosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: adenylate kinase 3

Names: ADENYLATE KINASE - 3; Ak3-PA; Ak3-PB; Ak3-PC; Ak3-PD; CG6612-PA; CG6612-PB; CG6612-PC; CG6612-PD; adenylate kinase-3

NP_001287279.1

EC 2.7.4.-

EC 2.7.4.10

EC 2.7.4.3

NP_001287280.1

EC 2.7.4.-

EC 2.7.4.10

EC 2.7.4.3

NP_524312.1

EC 2.7.4.-

EC 2.7.4.10

EC 2.7.4.3

NP_731529.1

EC 2.7.4.-

EC 2.7.4.10

EC 2.7.4.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

10887345..10889588 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001300350.1 → NP_001287279.1 adenylate kinase 3, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287279.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VGU6

Conserved Domains (2) summary

cd01428
Location:7 → 201

ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

TIGR01351
Location:7 → 211

adk; adenylate kinase
NM_001300351.1 → NP_001287280.1 adenylate kinase 3, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287280.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VGU6

Conserved Domains (2) summary

cd01428
Location:7 → 201

ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

TIGR01351
Location:7 → 211

adk; adenylate kinase
NM_079588.3 → NP_524312.1 adenylate kinase 3, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524312.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VGU6

Related

FBpp0081807

Conserved Domains (2) summary

cd01428
Location:7 → 201

ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

TIGR01351
Location:7 → 211

adk; adenylate kinase
NM_169373.2 → NP_731529.1 adenylate kinase 3, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731529.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VGU6

Related

FBpp0081806

Conserved Domains (2) summary

cd01428
Location:7 → 201

ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

TIGR01351
Location:7 → 211

adk; adenylate kinase