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MAFG MAF bZIP transcription factor G [ Homo sapiens (human) ]

Gene ID: 4097, updated on 5-Mar-2024

Summary

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Official Symbol
MAFGprovided by HGNC
Official Full Name
MAF bZIP transcription factor Gprovided by HGNC
Primary source
HGNC:HGNC:6781
See related
Ensembl:ENSG00000197063 MIM:602020; AllianceGenome:HGNC:6781
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
hMAF
Summary
Globin gene expression is regulated through nuclear factor erythroid-2 (NFE2) elements located in enhancer-like locus control regions positioned many kb upstream of alpha- and beta-gene clusters (summarized by Blank et al., 1997 [PubMed 9166829]). NFE2 DNA-binding activity consists of a heterodimer containing a ubiquitous small Maf protein (MafF, MIM 604877; MafG; or MafK, MIM 600197) and the tissue-restricted protein p45 NFE2 (MIM 601490). Both subunits are members of the activator protein-1-like superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160).[supplied by OMIM, Mar 2010]
Expression
Ubiquitous expression in bone marrow (RPKM 12.5), brain (RPKM 8.7) and 25 other tissues See more
Orthologs
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Genomic context

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See MAFG in Genome Data Viewer
Location:
17q25.3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (81918270..81931244, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (82785430..82798403, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79876146..79885611, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9163 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9164 Neighboring gene phosphate cytidylyltransferase 2, ethanolamine Neighboring gene neuropeptide B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9165 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9166 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9167 Neighboring gene sirtuin 7 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79875237-79876133 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12984 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:79880785-79881984 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79882682-79883637 Neighboring gene MAFG antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12985 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9169 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9170 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9171 Neighboring gene MYC inducible lncRNA inactivating p53 Neighboring gene pyrroline-5-carboxylate reductase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9172 Neighboring gene myeloid associated differentiation marker like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. LncRNA MAFG-AS1 Upregulates Polo-Like Kinase-1 by Sponging miR-505 to Promote Gastric Adenocarcinoma Cell Proliferation. Fu Y, et al. Crit Rev Eukaryot Gene Expr, 2021. PMID 34591387
  2. The small protein MafG plays a critical role in MC3T3-E1 cell apoptosis induced by simulated microgravity and radiation. Wang H, et al. Biochem Biophys Res Commun, 2021 May 28. PMID 33819748
  3. High-expression of LncRNA MAFG-AS1 is associated with the prognostic of patients with colorectal cancer. Cui W, et al. Rev Assoc Med Bras (1992), 2020 Nov. PMID 33295405
  4. MAFG-driven astrocytes promote CNS inflammation. Wheeler MA, et al. Nature, 2020 Feb. PMID 32051591, Free PMC Article
  5. MAFG is a potential therapeutic target to restore chemosensitivity in cisplatin-resistant cancer cells by increasing reactive oxygen species. Vera-Puente O, et al. Transl Res, 2018 Oct. PMID 30053382, Free PMC Article

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MAFG-AS1/MAFG positive feedback loop contributes to cisplatin resistance in bladder urothelial carcinoma through antagonistic ferroptosis.
    Title: MAFG-AS1/MAFG positive feedback loop contributes to cisplatin resistance in bladder urothelial carcinoma through antagonistic ferroptosis.
  2. LncRNA MAFG-AS1 Upregulates Polo-Like Kinase-1 by Sponging miR-505 to Promote Gastric Adenocarcinoma Cell Proliferation.
    Title: LncRNA MAFG-AS1 Upregulates Polo-Like Kinase-1 by Sponging miR-505 to Promote Gastric Adenocarcinoma Cell Proliferation.
  3. The small protein MafG plays a critical role in MC3T3-E1 cell apoptosis induced by simulated microgravity and radiation.
    Title: The small protein MafG plays a critical role in MC3T3-E1 cell apoptosis induced by simulated microgravity and radiation.
  4. High-expression of LncRNA MAFG-AS1 is associated with the prognostic of patients with colorectal cancer.
    Title: High-expression of LncRNA MAFG-AS1 is associated with the prognostic of patients with colorectal cancer.
  5. MAFG-lncRNA controlled hepatic glucose metabolism in health and metabolic disease.
    Title: A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism.
  6. identification of astrocytes in EAE and multiple sclerosis that were characterized by decreased expression of NRF2 and increased expression of MAFG, which cooperates with MAT2alpha to promote DNA methylation and represses antioxidant and anti-inflammatory transcriptional programs
    Title: MAFG-driven astrocytes promote CNS inflammation.
  7. LncRNA MAFG-AS1 boosts the proliferation of lung adenocarcinoma cells via regulating miR-744-5p/MAFG axis
    Title: LncRNA MAFG-AS1 boosts the proliferation of lung adenocarcinoma cells via regulating miR-744-5p/MAFG axis.
  8. Over-expression of MAFG-AS1 significantly decreased the level of miR-339-5p in NSCLC cell. Moreover, the matrix metalloproteinase 15 (MMP15) was identified to be a target of miR-339-5p.
    Title: LncRNA MAFG-AS1 facilitates the migration and invasion of NSCLC cell via sponging miR-339-5p from MMP15.
  9. musculoaponeurotic fibrosarcoma oncogene family, protein G (MAFG) modulates the redox response and confers cell protection against free radicals generated after platinum administration thus also being a promising therapeutic target in non-small-cell lung cancer drug therapy
    Title: MAFG is a potential therapeutic target to restore chemosensitivity in cisplatin-resistant cancer cells by increasing reactive oxygen species.
  10. Expression of MAFG increases in cells and tissues with cholestasis, as well as in human cholangiocarcinoma and hepatocellular carcinoma specimens; high expression levels correlate with tumor progression and reduced survival time.
    Title: Mechanisms of MAFG Dysregulation in Cholestatic Liver Injury and Development of Liver Cancer.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC13090, MGC20149

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in adult behavior IEA
Inferred from Electronic Annotation
more info
  
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of epidermal cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
transcription factor MafG
Names
basic leucine zipper transcription factor MafG
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002359.4 → NP_002350.1  transcription factor MafG

    See identical proteins and their annotated locations for NP_002350.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA775797, AC145207, BC103722, DR156847
    Consensus CDS
    CCDS11793.1
    UniProtKB/Swiss-Prot
    O15525
    Related
    ENSP00000350369.4, ENST00000357736.9
    Conserved Domains (1) summary
    cd14717
    Location:46 → 115
    bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain

  2. NM_032711.4 → NP_116100.2  transcription factor MafG

    See identical proteins and their annotated locations for NP_116100.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA775797, AC145207, BC012327, BC103722
    Consensus CDS
    CCDS11793.1
    UniProtKB/Swiss-Prot
    O15525
    Related
    ENSP00000376173.3, ENST00000392366.7
    Conserved Domains (1) summary
    cd14717
    Location:46 → 115
    bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    81918270..81931244 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047436070.1 → XP_047292026.1  transcription factor MafG isoform X1

    UniProtKB/Swiss-Prot
    O15525

  2. XM_047436071.1 → XP_047292027.1  transcription factor MafG isoform X1

    UniProtKB/Swiss-Prot
    O15525

  3. XM_047436072.1 → XP_047292028.1  transcription factor MafG isoform X1

    UniProtKB/Swiss-Prot
    O15525

  4. XM_047436068.1 → XP_047292024.1  transcription factor MafG isoform X1

    UniProtKB/Swiss-Prot
    O15525

  5. XM_047436069.1 → XP_047292025.1  transcription factor MafG isoform X1

    UniProtKB/Swiss-Prot
    O15525

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    82785430..82798403 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054316128.1 → XP_054172103.1  transcription factor MafG isoform X1

    UniProtKB/Swiss-Prot
    O15525

  2. XM_054316129.1 → XP_054172104.1  transcription factor MafG isoform X1

    UniProtKB/Swiss-Prot
    O15525

  3. XM_054316130.1 → XP_054172105.1  transcription factor MafG isoform X1

    UniProtKB/Swiss-Prot
    O15525

  4. XM_054316126.1 → XP_054172101.1  transcription factor MafG isoform X1

    UniProtKB/Swiss-Prot
    O15525

  5. XM_054316127.1 → XP_054172102.1  transcription factor MafG isoform X1

    UniProtKB/Swiss-Prot
    O15525
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O15525.1 GenPept UniProtKB/Swiss-Prot:O15525

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