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vdac3 voltage-dependent anion channel 3 [ Danio rerio (zebrafish) ]

Gene ID: 406529, updated on 27-Mar-2024

Summary

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Official Symbol
vdac3provided by ZNC
Official Full Name
voltage-dependent anion channel 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2380
See related
Ensembl:ENSDARG00000003695 AllianceGenome:ZFIN:ZDB-GENE-040426-2380
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:77898; wu:fb01e12
Summary
Predicted to enable voltage-gated anion channel activity. Acts upstream of or within fin regeneration. Predicted to be located in membrane and mitochondrion. Predicted to be integral component of membrane. Predicted to be part of pore complex. Predicted to be active in mitochondrial outer membrane. Is expressed in adaxial cell; musculature system; nervous system; somite; and trigeminal placode. Orthologous to human VDAC3 (voltage dependent anion channel 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 8
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (2412583..2434325, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (2354040..2375748, complement)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene plasminogen activator, tissue Neighboring gene inhibitor of nuclear factor kappa B kinase subunit beta Neighboring gene enkurin domain containing 1 Neighboring gene polymerase (DNA directed), beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Chronic unpredictable stress (CUS)-induced anxiety and related mood disorders in a zebrafish model: altered brain proteome profile implicates mitochondrial dysfunction. Chakravarty S, et al. PLoS One, 2013. PMID 23691016, Free PMC Article
  2. Proteomic analysis of zebrafish caudal fin regeneration. Saxena S, et al. Mol Cell Proteomics, 2012 Jun. PMID 22278371, Free PMC Article
  3. Characterization of Biological Pathways Regulating Acute Cold Resistance of Zebrafish. Ren J, et al. Int J Mol Sci, 2021 Mar 16. PMID 33809683, Free PMC Article
  4. Therapeutic potential of N-acetylcysteine in acrylamide acute neurotoxicity in adult zebrafish. Faria M, et al. Sci Rep, 2019 Nov 11. PMID 31712630, Free PMC Article
  5. Proteomic and gene expression analysis of zebrafish brain undergoing continuous light/dark stress. Purushothaman S, et al. J Sleep Res, 2015 Aug. PMID 25726855

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables porin activity IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated monoatomic anion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables voltage-gated monoatomic anion channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within fin regeneration IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within monoatomic anion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
part_of pore complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
voltage-dependent anion-selective channel protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213246.1 → NP_998411.1  voltage-dependent anion-selective channel protein 3

    See identical proteins and their annotated locations for NP_998411.1

    Status: PROVISIONAL

    Source sequence(s)
    BC065468
    UniProtKB/TrEMBL
    Q6P0S2
    Conserved Domains (1) summary
    cd07306
    Location:4 → 282
    Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    2412583..2434325 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005166744.4 → XP_005166801.1  voltage-dependent anion-selective channel protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A8M2BE54, B0R197
    Related
    ENSDARP00000121437.1, ENSDART00000134044.3
    Conserved Domains (1) summary
    cd07306
    Location:39 → 317
    Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane

  2. XM_005166743.4 → XP_005166800.1  voltage-dependent anion-selective channel protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BEA2
    Conserved Domains (1) summary
    cd07306
    Location:39 → 318
    Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane

  3. XM_005166746.3 → XP_005166803.1  voltage-dependent anion-selective channel protein 3 isoform X4

    UniProtKB/TrEMBL
    A0A8M2BEA1
    Related
    ENSDARP00000123532.1, ENSDART00000137262.2
    Conserved Domains (1) summary
    cd07306
    Location:29 → 307
    Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane

  4. XM_005166745.2 → XP_005166802.1  voltage-dependent anion-selective channel protein 3 isoform X3

    UniProtKB/TrEMBL
    A0A8M2BER1
    Conserved Domains (1) summary
    cd07306
    Location:29 → 308
    Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane
Nucleotide Protein Strain
Heading Accession and Version

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