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akirin1 akirin 1 [ Danio rerio (zebrafish) ]

Gene ID: 406432, updated on 27-Mar-2024

Summary

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Official Symbol
akirin1provided by ZNC
Official Full Name
akirin 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2178
See related
Ensembl:ENSDARG00000039969 AllianceGenome:ZFIN:ZDB-GENE-040426-2178
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:64050; wu:fa96c11; wu:fc08a11
Summary
Predicted to enable transcription coregulator activity. Predicted to be involved in several processes, including myoblast migration involved in skeletal muscle regeneration; positive regulation of lamellipodium assembly; and positive regulation of macrophage chemotaxis. Predicted to be active in chromatin and nucleus. Orthologous to human AKIRIN1 (akirin 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See akirin1 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (33121217..33140580)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (33167187..33186550)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene proline-rich nuclear receptor coactivator 2 Neighboring gene cannabinoid receptor 2 Neighboring gene rhomboid, veinlet-like 2 (Drosophila) Neighboring gene gap junction protein alpha 9a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Vaccination with Alpha-Gal Protects Against Mycobacterial Infection in the Zebrafish Model of Tuberculosis. Pacheco I, et al. Vaccines (Basel), 2020 Apr 24. PMID 32344637, Free PMC Article
  2. Pnrc2 regulates 3'UTR-mediated decay of segmentation clock-associated transcripts during zebrafish segmentation. Gallagher TL, et al. Dev Biol, 2017 Sep 1. PMID 28648842, Free PMC Article
  3. Pou3f transcription factor expression during embryonic development highlights distinct pou3f3 and pou3f4 localization in the Xenopus laevis kidney. Cosse-Etchepare C, et al. Int J Dev Biol, 2018. PMID 29877572
  4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC171578

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in myoblast migration involved in skeletal muscle regeneration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of skeletal muscle satellite cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of lamellipodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of macrophage chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of myoblast differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
akirin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007186.2 → NP_001007187.1  akirin-1 isoform 2

    See identical proteins and their annotated locations for NP_001007187.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    BC053224, EH585208
    UniProtKB/TrEMBL
    B7ZUY0, Q7T377
    Related
    ENSDARP00000058471.5, ENSDART00000058472.6
    Conserved Domains (1) summary
    cl41779
    Location:2 → 189
    akirin

  2. NM_001113800.2 → NP_001107272.1  akirin-1 isoform 1

    See identical proteins and their annotated locations for NP_001107272.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC053224, BC158177, EH585208
    UniProtKB/TrEMBL
    A0A8N7UYQ1, B0BLV7
    Related
    ENSDARP00000104170.1, ENSDART00000110195.3

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    33121217..33140580
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394965.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    143797..160199
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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