gapdhs glyceraldehyde-3-phosphate dehydrogenase, spermatogenic [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gapdhsprovided by ZNC
Official Full Name: glyceraldehyde-3-phosphate dehydrogenase, spermatogenicprovided by ZNC
Primary source: ZFIN:ZDB-GENE-020913-1
See related: Ensembl:ENSDARG00000039914 AllianceGenome:ZFIN:ZDB-GENE-020913-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb350; g3pdh; gapdh; gapds; fb71f08; fk58c09; gapdh-2; zgc:76908; wu:fb71f08; wu:fk58c09
Summary: Predicted to enable glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity. Predicted to be involved in glycolytic process. Predicted to act upstream of or within glucose metabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including cardiovascular system; digestive system; female organism; nervous system; and neural tube. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human GAPDHS (glyceraldehyde-3-phosphate dehydrogenase, spermatogenic). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (45044642..45069814, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (45077926..45103098, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fj77h01.x1 (e-PCR)
- UniSTS:199876

fk56d06.x1 (e-PCR)
- UniSTS:201202

fb71f08 (e-PCR)
- UniSTS:187390

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables NADP binding	IEA Inferred from Electronic Annotation more info
enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	IBA Inferred from Biological aspect of Ancestor more info
enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within glucose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycolytic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glycolytic process	IEA Inferred from Electronic Annotation more info
involved_in glycolytic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glyceraldehyde-3-phosphate dehydrogenase 2

Names: glyceraldehyde 3-phosphate dehydrogenase, testis-specific; spermatogenic glyceraldehyde-3-phosphate dehydrogenase

NP_998259.1

EC 1.2.1.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213094.2 → NP_998259.1 glyceraldehyde-3-phosphate dehydrogenase 2

See identical proteins and their annotated locations for NP_998259.1

Status: PROVISIONAL

Source sequence(s)

BC154822

UniProtKB/Swiss-Prot

Q5MJ86

Related

ENSDARP00000058383.5, ENSDART00000058384.6

Conserved Domains (3) summary

COG0057
Location:6 → 331

GapA; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]

pfam00044
Location:6 → 152

Gp_dh_N; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain

pfam02800
Location:157 → 314

Gp_dh_C; Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain