mtpn myotrophin [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mtpnprovided by ZNC
Official Full Name: myotrophinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2166
See related: Ensembl:ENSDARG00000104018 AllianceGenome:ZFIN:ZDB-GENE-040426-2166
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:64078; wu:fa10f07
Summary: Predicted to be involved in regulation of barbed-end actin filament capping. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human MTPN (myotrophin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (1054708..1076053, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (1041260..1054700, complement)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fd11e08.x1 (e-PCR)
- UniSTS:195141

z6580 (e-PCR), detects polymorphism
- UniSTS:204900

G45296 (e-PCR)
- UniSTS:106098

fa10f07.s1 (e-PCR)
- UniSTS:188802

G40453 (e-PCR)
- UniSTS:68830

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in regulation of barbed-end actin filament capping	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: myotrophin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212972.2 → NP_998137.1 myotrophin

See identical proteins and their annotated locations for NP_998137.1

Status: VALIDATED

Source sequence(s)

CR548631, EB940788, EH440876, EH524721

UniProtKB/Swiss-Prot

Q7T2B9

Related

ENSDARP00000141690.1, ENSDART00000172320.2

Conserved Domains (3) summary

cd00204
Location:6 → 117

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:6 → 97

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:1 → 32

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007115.7 Reference GRCz11 Primary Assembly

Range

1054708..1076053 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021474978.1 → XP_021330653.1 myotrophin isoform X1

UniProtKB/TrEMBL

A0A8M9PUB2

Conserved Domains (2) summary

cd00204
Location:60 → 171

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:55 → 86

ANK; ANK repeat [structural motif]