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Bex4 brain expressed X-linked 4 [ Mus musculus (house mouse) ]

Gene ID: 406217, updated on 2-May-2024

Summary

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Official Symbol
Bex4provided by MGI
Official Full Name
brain expressed X-linked 4provided by MGI
Primary source
MGI:MGI:3606746
See related
Ensembl:ENSMUSG00000047844 AllianceGenome:MGI:3606746
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable alpha-tubulin binding activity and histone deacetylase binding activity. Involved in regulation of mitotic cell cycle. Located in cytoplasm. Is expressed in several structures, including alimentary system; aorta; brain; genitourinary system; and liver. Orthologous to human BEX4 (brain expressed X-linked 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta adult (RPKM 179.6), liver E14 (RPKM 115.6) and 9 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X F1; X 57.4 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (135039745..135041192)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (136138996..136140443)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene brain expressed X-linked 2 Neighboring gene nuclear RNA export factor 3 Neighboring gene RIKEN cDNA 5730412P04 gene Neighboring gene transcription elongation factor A (SII)-like 8 Neighboring gene microRNA 6383

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. BEX4 upregulation alters Sertoli cell growth properties and protein expression profiles: An explanation for cadmium-induced testicular Sertoli cell injury. Yu W, et al. J Biochem Mol Toxicol, 2017 Jul. PMID 28295929
  2. Immunolocalization of Bex protein in the mouse brain and olfactory system. Koo JH, et al. J Comp Neurol, 2005 Jun 20. PMID 15861462
  3. Gene targeting study reveals unexpected expression of brain-expressed X-linked 2 in endocrine and tissue stem/progenitor cells in mice. Ito K, et al. J Biol Chem, 2014 Oct 24. PMID 25143383, Free PMC Article
  4. Characterization of the Bex gene family in humans, mice, and rats. Alvarez E, et al. Gene, 2005 Aug 29. PMID 15958283
  5. Characterization of an eutherian gene cluster generated after transposon domestication identifies Bex3 as relevant for advanced neurological functions. Navas-Pérez E, et al. Genome Biol, 2020 Oct 26. PMID 33100228, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. present study provides the first evidence that BEX4 upregulation induces alterations in Sertoli cell growth properties and protein expression profiles, which may be an explanation for Cd-induced testicular Sertoli cell injury
    Title: BEX4 upregulation alters Sertoli cell growth properties and protein expression profiles: An explanation for cadmium-induced testicular Sertoli cell injury.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-tubulin binding ISO
Inferred from Sequence Orthology
more info
  
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular function inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromosome segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of tubulin deacetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein BEX4
Names
BEX1-like protein 1
brain expressed gene 4
brain-expressed X-linked protein 4 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359569.1 → NP_001346498.1  protein BEX4

    Status: VALIDATED

    Source sequence(s)
    AL671914, BC090663
    Consensus CDS
    CCDS30414.1
    UniProtKB/Swiss-Prot
    Q9CWT2
    UniProtKB/TrEMBL
    Q14BB8
    Conserved Domains (1) summary
    pfam04538
    Location:26 → 114
    BEX; Brain expressed X-linked like family

  2. NM_001359570.1 → NP_001346499.1  protein BEX4

    Status: VALIDATED

    Source sequence(s)
    AK010400, AL118340, AL671914, BC090663
    Consensus CDS
    CCDS30414.1
    UniProtKB/Swiss-Prot
    Q9CWT2
    UniProtKB/TrEMBL
    Q14BB8
    Conserved Domains (1) summary
    pfam04538
    Location:26 → 114
    BEX; Brain expressed X-linked like family

  3. NM_212457.3 → NP_997622.1  protein BEX4

    See identical proteins and their annotated locations for NP_997622.1

    Status: VALIDATED

    Source sequence(s)
    AK010400, AL671914, BC090663
    Consensus CDS
    CCDS30414.1
    UniProtKB/Swiss-Prot
    Q9CWT2
    UniProtKB/TrEMBL
    Q14BB8
    Related
    ENSMUSP00000112226.2, ENSMUST00000116527.2
    Conserved Domains (1) summary
    pfam04538
    Location:26 → 114
    BEX; Brain expressed X-linked like family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    135039745..135041192
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CWT2.1 GenPept UniProtKB/Swiss-Prot:Q9CWT2

Gene LinkOut

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