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Ssl1 Suppressor of stem-loop mutation [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40509, updated on 10-May-2024

Summary

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Official Symbol
Ssl1provided by FlyBase
Official Full Name
Suppressor of stem-loop mutationprovided by FlyBase
Primary source
FLYBASE:FBgn0037202
Locus tag
Dmel_CG11115
See related
AllianceGenome:FB:FBgn0037202
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11115; Dmel\CG11115; p44; ssl1; SSL1
Summary
Predicted to enable zinc ion binding activity. Involved in transcription by RNA polymerase II. Part of transcription factor TFIIH holo complex. Is expressed in organism. Orthologous to several human genes including GTF2H2C (GTF2H2 family member C). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See Ssl1 in Genome Data Viewer
Location:
80B2-80B2; 3-47 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (22879089..22880963)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (22872189..22874063)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene ADP ribosylation factor 1 Neighboring gene antisense RNA:CR45968 Neighboring gene uncharacterized protein Neighboring gene Chromator Neighboring gene antisense RNA:CR45970 Neighboring gene slimfast Neighboring gene long non-coding RNA:CR44688

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Chromator, a novel and essential chromodomain protein interacts directly with the putative spindle matrix protein skeletor. Rath U, et al. J Cell Biochem, 2004 Nov 15. PMID 15389869
  2. The chromodomain protein, Chromator, interacts with JIL-1 kinase and regulates the structure of Drosophila polytene chromosomes. Rath U, et al. J Cell Sci, 2006 Jun 1. PMID 16723739
  3. DNA repair and transcriptional deficiencies caused by mutations in the Drosophila p52 subunit of TFIIH generate developmental defects and chromosome fragility. Fregoso M, et al. Mol Cell Biol, 2007 May. PMID 17339330, Free PMC Article
  4. A Drosophila XPD model links cell cycle coordination with neuro-development and suggests links to cancer. Stettler K, et al. Dis Model Mech, 2015 Jan. PMID 25431422, Free PMC Article
  5. Using qualitative probability in reverse-engineering gene regulatory networks. Ibrahim ZM, et al. IEEE/ACM Trans Comput Biol Bioinform, 2011 Mar-Apr. PMID 20876933

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in RNA polymerase II promoter clearance ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in nucleotide-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleotide-excision repair IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleotide-excision repair ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription initiation at RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in transcription open complex formation at RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of transcription factor TFIIH core complex IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIIH core complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of transcription factor TFIIH holo complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIH holo complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription factor TFIIH holo complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
suppressor of stem-loop mutation
Names
CG11115-PA
CG11115-PB
Ssl1-PA
Ssl1-PB
suppressor of Stem-Loop mutation ortholog

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    22879089..22880963
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141170.3 → NP_649427.1  suppressor of stem-loop mutation, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649427.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VNP8
    Related
    FBpp0078205
    Conserved Domains (3) summary
    pfam04056
    Location:67 → 258
    Ssl1; Ssl1-like
    COG5151
    Location:10 → 407
    SSL1; RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1 [Transcription / DNA replication, recombination, and repair]
    cl06838
    Location:291 → 403
    C1_4; TFIIH C1-like domain

  2. NM_001275298.1 → NP_001262227.1  suppressor of stem-loop mutation, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262227.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VNP8
    Conserved Domains (3) summary
    pfam04056
    Location:67 → 258
    Ssl1; Ssl1-like
    COG5151
    Location:10 → 407
    SSL1; RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1 [Transcription / DNA replication, recombination, and repair]
    cl06838
    Location:291 → 403
    C1_4; TFIIH C1-like domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VNP8 Q9VNP8

Gene LinkOut

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