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Arf1 ADP ribosylation factor 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40506, updated on 26-Apr-2024

Summary

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Official Symbol
Arf1provided by FlyBase
Official Full Name
ADP ribosylation factor 1provided by FlyBase
Primary source
FLYBASE:FBgn0010348
Locus tag
Dmel_CG8385
See related
AllianceGenome:FB:FBgn0010348
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Arf; ARF-1; arf1; ARF1; ARF1_DROME; Arf79; Arf79f; Arf79F; CG8385; d-Arf1; dArf1; Darf1; dArf79F; dARF79F; dARFI; Dm Arf79F; Dmel\CG8385; P61209
Summary
Enables GTPase activity. Involved in several processes, including ARF protein signal transduction; cytoskeleton-dependent cytokinesis; and hematopoietic stem cell homeostasis. Located in several cellular components, including Golgi stack; cleavage furrow; and lysosome. Colocalizes with intracellular membrane-bounded organelle. Is expressed in several structures, including adult head and circulatory system. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to several human genes including ARF1 (ADP ribosylation factor 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
80B1-80B1; 3-47 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (22868380..22872231, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (22861480..22865331, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ER membrane protein complex subunit 4 Neighboring gene antisense RNA:CR45969 Neighboring gene antisense RNA:CR45968 Neighboring gene uncharacterized protein Neighboring gene Chromator Neighboring gene antisense RNA:CR45970 Neighboring gene Suppressor of stem-loop mutation

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular characterization of a conserved, guanine nucleotide-dependent ADP-ribosylation factor in Drosophila melanogaster. Murtagh JJ Jr, et al. Biochemistry, 1993 Jun 15. PMID 8507638
  2. Expression, Purification and Crystallization of Asrij, A Novel Scaffold Transmembrane Protein. Motiwala Z, et al. J Membr Biol, 2021 Feb. PMID 33433647
  3. Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting. Wilfling F, et al. Elife, 2014. PMID 24497546, Free PMC Article
  4. Intron "sliding" and the diversity of intron positions. Stoltzfus A, et al. Proc Natl Acad Sci U S A, 1997 Sep 30. PMID 9380704, Free PMC Article
  5. SnoRNA U21 is also intron-encoded in Drosophila melanogaster but in a different host-gene as compared to warm-blooded vertebrates. Renalier MH, et al. FEBS Lett, 1996 Feb 5. PMID 8603691

See all (129) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results show that in addition to its requirement in hematopoiesis, the ARF1-Asrij axis can differentially regulate humoral immunity in Drosophila, most likely by virtue of its endosomal function. ARF1 and Asrij bring about differential endocytic modulation of immune pathways and their depletion leads to aberrant pathway activity and an immune imbalance.
    Title: Differential modulation of the cellular and humoral immune responses in Drosophila is mediated by the endosomal ARF1-Asrij axis.
  2. Identification of Sec71 as a guanine nucleotide exchange factor for Arf1 that preferentially interacts with its GDP-bound form. Like Arf1, Sec71 is also important for dendrite pruning, but not for apoptosis of sensory neurons.
    Title: Sec71 functions as a GEF for the small GTPase Arf1 to govern dendrite pruning of Drosophila sensory neurons.
  3. Suggest a model in which Arf1/COPI machinery acts to control endoplasmic reticulum-lipid droplet connections for localization of key enzymes of triglyceride storage and catabolism.
    Title: Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting.
  4. ARF1-Asrij endocytic axis modulates signals that govern hematopoietic development.
    Title: ARF1-GTP regulates Asrij to provide endocytic control of Drosophila blood cell homeostasis.
  5. Sata indicate that the Class I Arf GTPase is a central component in WRC-driven lamellipodium formation.
    Title: The Drosophila Arf1 homologue Arf79F is essential for lamellipodium formation.
  6. Results suggest that N-cadherin is regulated in a Schizo/Loner- and d-Arf1-dependent manner.
    Title: The Arf-GEF Schizo/Loner regulates N-cadherin to induce fusion competence of Drosophila myoblasts.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in ARF protein signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in Golgi to plasma membrane protein transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in Golgi to plasma membrane protein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in compound eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in compound eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hematopoietic stem cell homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_positive_effect imaginal disc-derived wing morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in male meiosis cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cleavage furrow ingression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neurotransmitter secretion TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neuron remodeling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of neuron remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in post-Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of antibacterial peptide production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of lipid storage IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic vesicle endocytosis TAS
Traceable Author Statement
more info
 PubMed 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi stack IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical part of cell IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cleavage furrow IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ADP ribosylation factor 1
Names
ADP ribosylation factor 79F
ADP ribosylation factor at 79F
ADP-ribosylation factor 1
Arf1-PA
Arf1-PB
Arf1-PC
Arf1-PE
Arf1-PF
Arf1-PH
Arf1-PI
Arf1-PJ
CG8385-PA
CG8385-PB
CG8385-PC
CG8385-PE
CG8385-PF
CG8385-PH
CG8385-PI
CG8385-PJ

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    22868380..22872231 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168972.5 → NP_730759.1  ADP ribosylation factor 1, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730759.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V2B1, A8JNX4, P35676, P61209, Q9VNQ2
    UniProtKB/TrEMBL
    M9PG22
    Related
    FBpp0289184
    Conserved Domains (1) summary
    smart00177
    Location:5 → 179
    ARF; ARF-like small GTPases; ARF, ADP-ribosylation factor

  2. NM_001104198.2 → NP_001097668.2  ADP ribosylation factor 1, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097668.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V2B1, A8JNX4, P35676, P61209, Q9VNQ2
    UniProtKB/TrEMBL
    M9PG22
    Conserved Domains (1) summary
    smart00177
    Location:5 → 179
    ARF; ARF-like small GTPases; ARF, ADP-ribosylation factor

  3. NM_168970.4 → NP_730757.1  ADP ribosylation factor 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730757.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V2B1, A8JNX4, P35676, P61209, Q9VNQ2
    UniProtKB/TrEMBL
    M9PG22
    Related
    FBpp0078222
    Conserved Domains (1) summary
    smart00177
    Location:5 → 179
    ARF; ARF-like small GTPases; ARF, ADP-ribosylation factor

  4. NM_001104197.3 → NP_001097667.1  ADP ribosylation factor 1, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097667.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V2B1, A8JNX4, P35676, P61209, Q9VNQ2
    UniProtKB/TrEMBL
    M9PG22
    Conserved Domains (1) summary
    smart00177
    Location:5 → 179
    ARF; ARF-like small GTPases; ARF, ADP-ribosylation factor

  5. NM_001275296.1 → NP_001262225.1  ADP ribosylation factor 1, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262225.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V2B1, A8JNX4, P35676, P61209, Q9VNQ2
    UniProtKB/TrEMBL
    M9PG22
    Conserved Domains (1) summary
    smart00177
    Location:5 → 179
    ARF; ARF-like small GTPases; ARF, ADP-ribosylation factor

  6. NM_057607.6 → NP_476955.1  ADP ribosylation factor 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476955.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V2B1, A8JNX4, P35676, P61209, Q9VNQ2
    UniProtKB/TrEMBL
    M9PG22
    Related
    FBpp0078224
    Conserved Domains (1) summary
    smart00177
    Location:5 → 179
    ARF; ARF-like small GTPases; ARF, ADP-ribosylation factor

  7. NM_168973.3 → NP_730760.1  ADP ribosylation factor 1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730760.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V2B1, A8JNX4, P35676, P61209, Q9VNQ2
    UniProtKB/TrEMBL
    M9PG22
    Related
    FBpp0078225
    Conserved Domains (1) summary
    smart00177
    Location:5 → 179
    ARF; ARF-like small GTPases; ARF, ADP-ribosylation factor

  8. NM_168971.4 → NP_730758.1  ADP ribosylation factor 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730758.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V2B1, A8JNX4, P35676, P61209, Q9VNQ2
    UniProtKB/TrEMBL
    M9PG22
    Related
    FBpp0078226
    Conserved Domains (1) summary
    smart00177
    Location:5 → 179
    ARF; ARF-like small GTPases; ARF, ADP-ribosylation factor
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PG22 M9PG22
P61209.2 P61209

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