U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

aplp1 amyloid beta (A4) precursor-like protein 1 [ Danio rerio (zebrafish) ]

Gene ID: 404233, updated on 27-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
aplp1provided by ZNC
Official Full Name
amyloid beta (A4) precursor-like protein 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-040319-1
See related
Ensembl:ENSDARG00000098368 AllianceGenome:ZFIN:ZDB-GENE-040319-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
aplp; im:7153266; wu:fj55h01
Summary
Predicted to enable heparin binding activity and transition metal ion binding activity. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in central nervous system; cranial ganglion; neurons; retina; and retinal ganglion cell layer. Orthologous to human APLP1 (amyloid beta precursor like protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 15
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (37106119..37230362)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (37204410..37328745)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene NPHS1 adhesion molecule, nephrin Neighboring gene kirre like nephrin family adhesion molecule 3, like Neighboring gene ST14 transmembrane serine protease matriptase Neighboring gene uncharacterized LOC100333235 Neighboring gene uncharacterized LOC100535321 Neighboring gene uncharacterized LOC103908856

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A diaminomaleonitrile-appended BODIPY chemosensor for the selective detection of Cu(2+) via oxidative cyclization and imaging in SiHa cells and zebrafish. Li X, et al. Spectrochim Acta A Mol Biomol Spectrosc, 2020 Jun 5. PMID 32120291
  2. Amyloid precursor protein-b facilitates cell adhesion during early development in zebrafish. Banote RK, et al. Sci Rep, 2020 Jun 23. PMID 32576936, Free PMC Article
  3. Tol2 gene trap integrations in the zebrafish amyloid precursor protein genes appa and aplp2 reveal accumulation of secreted APP at the embryonic veins. Liao HK, et al. Dev Dyn, 2012 Feb. PMID 22275008, Free PMC Article
  4. Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains. Hogl S, et al. Proteomics, 2013 May. PMID 23457027
  5. Discovery and characterization of novel vascular and hematopoietic genes downstream of etsrp in zebrafish. Gomez GA, et al. PLoS One, 2009. PMID 19308258, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables alpha-2A adrenergic receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-2B adrenergic receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-2C adrenergic receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heparin binding IEA
Inferred from Electronic Annotation
more info
  
enables transition metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
amyloid-like protein 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    37106119..37230362
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001342885.8 → XP_001342921.4  amyloid-like protein 1

    UniProtKB/TrEMBL
    A0A0R4IXG2, A0A8M1PZM7
    Related
    ENSDARP00000140309.1, ENSDART00000157762.3
    Conserved Domains (5) summary
    smart00006
    Location:37 → 195
    A4_EXTRA; amyloid A4
    pfam02177
    Location:39 → 139
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam10515
    Location:670 → 720
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12924
    Location:141 → 195
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    pfam12925
    Location:339 → 520
    APP_E2; E2 domain of amyloid precursor protein
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous