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Agr3 anterior gradient 3 [ Mus musculus (house mouse) ]

Gene ID: 403205, updated on 5-Mar-2024

Summary

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Official Symbol
Agr3provided by MGI
Official Full Name
anterior gradient 3provided by MGI
Primary source
MGI:MGI:2685734
See related
Ensembl:ENSMUSG00000036231 AllianceGenome:MGI:2685734
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm888; BCMP11; E030025L21Rik
Summary
Predicted to enable dystroglycan binding activity. Predicted to be involved in negative regulation of cell death. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in endoplasmic reticulum. Orthologous to human AGR3 (anterior gradient 3, protein disulphide isomerase family member). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
12 A3; 12 15.97 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (35975620..35999736)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (35925621..35949737)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene heat shock protein 90 alpha (cytosolic), class B member 1 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr12:36525891-36526191 Neighboring gene predicted gene 9472 Neighboring gene STARR-seq mESC enhancer starr_31911 Neighboring gene STARR-seq mESC enhancer starr_31913 Neighboring gene anterior gradient 2 Neighboring gene tetraspanin 13 Neighboring gene STARR-positive B cell enhancer ABC_E10744 Neighboring gene STARR-positive B cell enhancer ABC_E2382

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Endoplasmic Reticulum Resident Protein AGR3. Required for Regulation of Ciliary Beat Frequency in the Airway. Bonser LR, et al. Am J Respir Cell Mol Biol, 2015 Oct. PMID 25751668, Free PMC Article
  2. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (4) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dystroglycan binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dystroglycan binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
anterior gradient protein 3
Names
anterior gradient homolog 3
anterior gradient protein 3 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207531.3 → NP_997414.2  anterior gradient protein 3 precursor

    See identical proteins and their annotated locations for NP_997414.2

    Status: VALIDATED

    Source sequence(s)
    AK053177, AW490945, BE650904
    Consensus CDS
    CCDS25880.1
    UniProtKB/Swiss-Prot
    A7NSI1, Q8BW95, Q8R3W7
    Related
    ENSMUSP00000049212.5, ENSMUST00000042101.5
    Conserved Domains (1) summary
    cd02960
    Location:36 → 165
    AGR; Anterior Gradient (AGR) family; members of this family are similar to secreted proteins encoded by the cement gland-specific genes XAG-1 and XAG-2, expressed in the anterior region of dorsal ectoderm of Xenopus. They are implicated in the formation of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    35975620..35999736
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515142.4 → XP_006515205.1  anterior gradient protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006515205.1

    Conserved Domains (1) summary
    cl00388
    Location:1 → 104
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

  2. XM_006515143.1 → XP_006515206.1  anterior gradient protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006515206.1

    Conserved Domains (1) summary
    cl00388
    Location:1 → 104
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R3W7.1 GenPept UniProtKB/Swiss-Prot:Q8R3W7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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