Atg3 Autophagy-related 3 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Atg3provided by FlyBase
Official Full Name: Autophagy-related 3provided by FlyBase
Primary source: FLYBASE:FBgn0036813
Locus tag: Dmel_CG6877
See related: AllianceGenome:FB:FBgn0036813
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: atg3; ATG3; Aut-1; Aut1; AUT1; CG6877; dAtg3; Dmel\CG6877; Draut1
Summary: Predicted to enable Atg8 ligase activity. Involved in autophagosome assembly; cellular response to starvation; and glycophagy. Located in autophagosome and cytosol. Is expressed in several structures, including embryonic brain; embryonic/larval garland cell; embryonic/larval midgut; extended germ band embryo; and larval ventral nerve cord. Orthologous to human ATG3 (autophagy related 3). [provided by Alliance of Genome Resources, Apr 2022]
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (18748687..18750483)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (18741787..18743583)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Draut1 is essential for autophagy and development.
Title: The Drosophila homolog of Aut1 is essential for autophagy and development.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables Atg8-family ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables Atg8-family ligase activity	IEA Inferred from Electronic Annotation more info
enables Atg8-family ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin-like protein transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in T-tubule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagy of mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycophagy	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in larval midgut cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleophagy	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in autophagosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in phagophore assembly site	IBA Inferred from Biological aspect of Ancestor more info

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The following sections contain reference sequences that belong to a specific genome build. Explain