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Btbd6 BTB domain containing 6 [ Mus musculus (house mouse) ]

Gene ID: 399566, updated on 5-Mar-2024

Summary

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Official Symbol
Btbd6provided by MGI
Official Full Name
BTB domain containing 6provided by MGI
Primary source
MGI:MGI:3026623
See related
Ensembl:ENSMUSG00000002803 AllianceGenome:MGI:3026623
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to be involved in neurogenesis. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Orthologous to human BTBD6 (BTB domain containing 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 15.5), ovary adult (RPKM 14.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 F1; 12 61.5 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (112937880..112943113)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (112974260..112979493)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene jagged 2 Neighboring gene microRNA 6941 Neighboring gene STARR-positive B cell enhancer ABC_E11526 Neighboring gene STARR-seq mESC enhancer starr_33372 Neighboring gene nudix hydrolase 14 Neighboring gene BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit Neighboring gene RIKEN cDNA 9230104M06 gene Neighboring gene STARR-positive B cell enhancer ABC_E1866 Neighboring gene phosphofurin acidic cluster sorting protein 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:114285178-114285287 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:114285299-114285486

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
BTB/POZ domain-containing protein 6
Names
BTB (POZ) domain containing 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145900.1 → NP_001139372.1  BTB/POZ domain-containing protein 6 isoform 2

    See identical proteins and their annotated locations for NP_001139372.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream translational start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AA870939, AI118479, AI119004, AK146991
    Consensus CDS
    CCDS49194.1
    UniProtKB/Swiss-Prot
    Q8K2J9
    Related
    ENSMUSP00000127286.2, ENSMUST00000165079.8
    Conserved Domains (3) summary
    cd18349
    Location:78 → 186
    BTB_POZ_BTBD6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6)
    cd18525
    Location:186 → 280
    BACK_BTBD6; BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 6 (BTBD6)
    pfam08005
    Location:343 → 486
    PHR; PHR domain

  2. NM_201646.2 → NP_964008.2  BTB/POZ domain-containing protein 6 isoform 1 precursor

    See identical proteins and their annotated locations for NP_964008.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA870939, AI118479, AK146991, BY337984
    Consensus CDS
    CCDS49193.1
    UniProtKB/Swiss-Prot
    Q3UIB3, Q8K2J9
    UniProtKB/TrEMBL
    G5E817
    Related
    ENSMUSP00000002880.7, ENSMUST00000002880.7
    Conserved Domains (4) summary
    smart00225
    Location:138 → 237
    BTB; Broad-Complex, Tramtrack and Bric a brac
    smart00875
    Location:243 → 349
    BACK; BTB And C-terminal Kelch
    pfam00651
    Location:130 → 233
    BTB; BTB/POZ domain
    pfam08005
    Location:394 → 537
    PHR; PHR domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    112937880..112943113
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315125.2 → XP_017170614.1  BTB/POZ domain-containing protein 6 isoform X3

    Conserved Domains (3) summary
    cd18525
    Location:76 → 170
    BACK_BTBD6; BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 6 (BTBD6)
    cl38908
    Location:24 → 76
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam08005
    Location:233 → 376
    PHR; PHR domain

  2. XM_006516056.4 → XP_006516119.1  BTB/POZ domain-containing protein 6 isoform X1

    See identical proteins and their annotated locations for XP_006516119.1

    UniProtKB/Swiss-Prot
    Q8K2J9
    Conserved Domains (3) summary
    cd18349
    Location:78 → 186
    BTB_POZ_BTBD6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6)
    cd18525
    Location:186 → 280
    BACK_BTBD6; BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 6 (BTBD6)
    pfam08005
    Location:343 → 486
    PHR; PHR domain

  3. XM_017315126.2 → XP_017170615.1  BTB/POZ domain-containing protein 6 isoform X2

    Conserved Domains (3) summary
    cd18525
    Location:69 → 163
    BACK_BTBD6; BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 6 (BTBD6)
    cl38908
    Location:1 → 69
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam08005
    Location:225 → 370
    PHR; PHR domain

  4. XM_017315127.1 → XP_017170616.1  BTB/POZ domain-containing protein 6 isoform X2

    Conserved Domains (3) summary
    cd18525
    Location:69 → 163
    BACK_BTBD6; BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 6 (BTBD6)
    cl38908
    Location:1 → 69
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam08005
    Location:225 → 370
    PHR; PHR domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K2J9.3 GenPept UniProtKB/Swiss-Prot:Q8K2J9

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