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ADRA2A adrenoceptor alpha 2A [ Sus scrofa (pig) ]

Gene ID: 399501, updated on 5-Mar-2024

Summary

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Official Symbol
ADRA2Aprovided by VGNC
Official Full Name
adrenoceptor alpha 2Aprovided by VGNC
Primary source
VGNC:VGNC:85156
See related
Ensembl:ENSSSCG00000010629
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
ADRA2; PORA2AR
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 14
Exon count:
1
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 14 NC_010456.5 (121469572..121470924)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 14 NC_010456.4 (132403894..132405246)

Chromosome 14 - NC_010456.5Genomic Context describing neighboring genes Neighboring gene BBSome interacting protein 1 Neighboring gene SHOC2 leucine rich repeat scaffold protein Neighboring gene uncharacterized LOC102167161 Neighboring gene uncharacterized LOC102167253 Neighboring gene fumarylacetoacetate hydrolase domain containing 1 Neighboring gene uncharacterized LOC110256734

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutations of the alpha 2A-adrenergic receptor that eliminate detectable palmitoylation do not perturb receptor-G-protein coupling. Kennedy ME, et al. J Biol Chem, 1993 Apr 15. PMID 8385131
  2. An aspartate conserved among G-protein receptors confers allosteric regulation of alpha 2-adrenergic receptors by sodium. Horstman DA, et al. J Biol Chem, 1990 Dec 15. PMID 2174879
  3. Cloning, sequencing, and expression of the gene encoding the porcine alpha 2-adrenergic receptor. Allosteric modulation by Na+, H+, and amiloride analogs. Guyer CA, et al. J Biol Chem, 1990 Oct 5. PMID 2170371
  4. A point mutation of the alpha 2-adrenoceptor that blocks coupling to potassium but not calcium currents. Surprenant A, et al. Science, 1992 Aug 14. PMID 1354394
  5. Function and expression of sulfonylurea, adrenergic, and glucagon-like peptide 1 receptors in isolated porcine islets. Kelly AC, et al. Xenotransplantation, 2014 Jul-Aug. PMID 24801676, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables alpha2-adrenergic receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in platelet activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of vasoconstriction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
alpha-2A adrenergic receptor
Names
adrenergic, alpha-2A-, receptor
alpha-2A adrenoceptor
alpha-2A adrenoreceptor
alpha-2AAR
alpha2A-adrenergic receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_214400.1 → NP_999565.1  alpha-2A adrenergic receptor

    See identical proteins and their annotated locations for NP_999565.1

    Status: PROVISIONAL

    Source sequence(s)
    J05652
    UniProtKB/Swiss-Prot
    P18871
    Related
    ENSSSCP00000011323.3, ENSSSCT00000011625.3
    Conserved Domains (2) summary
    pfam00001
    Location:50 → 426
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:42 → 170
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010456.5 Reference Sscrofa11.1 Primary Assembly

    Range
    121469572..121470924
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P18871.2 GenPept UniProtKB/Swiss-Prot:P18871

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.