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AR androgen receptor [ Sus scrofa (pig) ]

Gene ID: 397582, updated on 5-Mar-2024

Summary

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Official Symbol
ARprovided by VGNC
Official Full Name
androgen receptorprovided by VGNC
Primary source
VGNC:VGNC:103903
See related
Ensembl:ENSSSCG00000012371
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
SBMA; NR3C4
Expression
Biased expression in ovary (RPKM 6.6), kidney (RPKM 4.2) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: X
Exon count:
9
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) X NC_010461.5 (53609113..53806778)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) X NC_010461.4 (60313281..60504529)

Chromosome X - NC_010461.5Genomic Context describing neighboring genes Neighboring gene ectodysplasin A2 receptor Neighboring gene extended synaptotagmin-2 pseudogene Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene oligophrenin 1 Neighboring gene ceramide synthase 5 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Does 2-hydroxyflutamide inhibit apoptosis in porcine granulosa cells? - An in vitro study. Duda M, et al. J Reprod Dev, 2012. PMID 22522230
  2. Tissue-specific distribution of the androgen receptor (AR) in the porcine fetus. Burek M, et al. Acta Histochem, 2007. PMID 17482664
  3. Polymorphisms of the porcine androgen receptor gene affecting its amino acid sequence and expression level. Trakooljul N, et al. Biochim Biophys Acta, 2004 May 25. PMID 15157735
  4. A highly polymorphic repetitive polypyrimidine/polypurine (CCTTT)n sequence in the 5' untranslated sequence of the porcine androgen receptor gene. Trakooljul N, et al. Anim Genet, 2000 Aug. PMID 11086548
  5. Androgen signaling disruption during fetal and postnatal development affects androgen receptor and connexin 43 expression and distribution in adult boar prostate. Hejmej A, et al. Biomed Res Int, 2013. PMID 24151599, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In GD20 and PD2 males we found the reduction of the luminal compartment, inflammatory changes, decreased androgen receptor and increased Cx43 expression
    Title: Androgen signaling disruption during fetal and postnatal development affects androgen receptor and connexin 43 expression and distribution in adult boar prostate.
  2. Data suggest that signal transduction involving androgen receptor is involved in apoptosis of granulosa cells (as seen in follicular atresia).
    Title: Does 2-hydroxyflutamide inhibit apoptosis in porcine granulosa cells? - An in vitro study.
  3. presence of AR during gestation in non-gonadal tissues suggests a role of androgen in these tissues
    Title: Tissue-specific distribution of the androgen receptor (AR) in the porcine fetus.
  4. AR is a potential candidate gene for traits related to pig reproduction and performance
    Title: Polymorphisms of the porcine androgen receptor gene affecting its amino acid sequence and expression level.
  5. Pig ejaculated spermatozoa express androgen receptor.
    Title: Cytochrome P450arom, androgen and estrogen receptors in pig sperm.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables steroid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in androgen receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in male gonad development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
androgen receptor
Names
androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease)
androgen receptor AR
dihydrotestosterone receptor
nuclear receptor subfamily 3 group C member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_214314.2 → NP_999479.2  androgen receptor

    See identical proteins and their annotated locations for NP_999479.2

    Status: PROVISIONAL

    Source sequence(s)
    AF202775
    UniProtKB/Swiss-Prot
    Q9GKL7, Q9GKN9
    Conserved Domains (3) summary
    cd07073
    Location:649 → 894
    NR_LBD_AR; Ligand binding domain of the nuclear receptor androgen receptor, ligand activated transcription regulator
    cd07173
    Location:531 → 612
    NR_DBD_AR; DNA-binding domain of androgen receptor (AR) is composed of two C4-type zinc fingers
    pfam02166
    Location:6 → 437
    Androgen_recep; Androgen receptor

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010461.5 Reference Sscrofa11.1 Primary Assembly

    Range
    53609113..53806778
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021079513.1 → XP_020935172.1  androgen receptor isoform X2

    UniProtKB/TrEMBL
    A0A1B2TT49
    Conserved Domains (3) summary
    cd07173
    Location:531 → 605
    NR_DBD_AR; DNA-binding domain of androgen receptor (AR) is composed of two C4-type zinc fingers
    pfam02166
    Location:6 → 437
    Androgen_recep; Androgen receptor
    cl11397
    Location:603 → 798
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

  2. XM_013986227.2 → XP_013841681.1  androgen receptor isoform X1

    UniProtKB/TrEMBL
    A0A1B2TT49, A0A4X1VUS1, F1RTM6
    Related
    ENSSSCP00000013166.2, ENSSSCT00000013528.5
    Conserved Domains (3) summary
    cd07073
    Location:649 → 894
    NR_LBD_AR; Ligand binding domain of the nuclear receptor androgen receptor, ligand activated transcription regulator
    cd07173
    Location:531 → 612
    NR_DBD_AR; DNA-binding domain of androgen receptor (AR) is composed of two C4-type zinc fingers
    pfam02166
    Location:6 → 437
    Androgen_recep; Androgen receptor
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9GKL7.3 GenPept UniProtKB/Swiss-Prot:Q9GKL7

Gene LinkOut

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