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ACVR2A activin A receptor type 2A [ Gallus gallus (chicken) ]

Gene ID: 396324, updated on 3-Apr-2024

Summary

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Symbol
ACVR2Aprovided by CGNC
Full Name
activin A receptor type 2Aprovided by CGNC
Primary source
CGNC:9451
See related
Ensembl:ENSGALG00010009474
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 7
Exon count:
13
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 7 NC_052538.1 (34110247..34167721)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 7 NC_052579.1 (34027666..34085129)

Chromosome 7 - NC_052538.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107053852 Neighboring gene U1 spliceosomal RNA Neighboring gene origin recognition complex subunit 4 Neighboring gene uncharacterized LOC107053851 Neighboring gene uncharacterized LOC121111345 Neighboring gene methyl-CpG binding domain protein 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Gene expression and silencing of activin receptor type 2A (ACVR2A) in myoblast cells of chicken. Satheesh P, et al. Br Poult Sci, 2016 Dec. PMID 27635666
  2. Expression pattern of the activin receptor type IIA gene during differentiation of chick neural tissues, muscle and skin. Ohuchi H, et al. FEBS Lett, 1992 Jun 1. PMID 1318847
  3. Differential expression of mRNAs encoding the putative inhibin co-receptor (betaglycan) and activin type-I and type-II receptors in preovulatory and prehierarchical follicles of the laying hen ovary. Lovell TM, et al. J Endocrinol, 2006 Feb. PMID 16461550
  4. Variation in pituitary expression of mRNAs encoding the putative inhibin co-receptor (betaglycan) and type-I and type-II activin receptors during the chicken ovulatory cycle. Lovell TM, et al. J Endocrinol, 2005 Sep. PMID 16135664
  5. The activin signaling pathway promotes differentiation of dI3 interneurons in the spinal neural tube. Timmer J, et al. Dev Biol, 2005 Sep 1. PMID 16039645

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Comparative analysis of silencing expression of myostatin (MSTN) and its two receptors (ACVR2A and ACVR2B) genes affecting growth traits in knock down chicken.
    Title: Comparative analysis of silencing expression of myostatin (MSTN) and its two receptors (ACVR2A and ACVR2B) genes affecting growth traits in knock down chicken.
  2. Between broiler and layer lines, there were no significant changes in expression of the ACVR2A gene during embryonic stages but it varied significantly during the post-hatch period. The shRNA showed silencing of the ACVR2A gene under an in vitro cell culture system.
    Title: Gene expression and silencing of activin receptor type 2A (ACVR2A) in myoblast cells of chicken.
  3. Chicken ACVR2A & ACVR2B cause formation of ectopic axial structures in amphibian embryos. Authors conclude that ACVR2 receptors affect axial patterning (GO:0009798 axis specification)
    Title: Activin and its receptors during gastrulation and the later phases of mesoderm development in the chick embryo.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables activin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables activin receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in activin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cellular response to growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of activin receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
activin receptor type-2A
Names
ACTR-IIA
ACTRIIA
activin A receptor, type IIA
activin receptor IIA
activin receptor type 2A
activin receptor type IIA
NP_990698.1
XP_015145278.1
XP_040559295.1
XP_046777112.1
XP_046777113.1
XP_046777114.1
XP_046777116.1
XP_046799456.1
XP_046799457.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205367.2 → NP_990698.1  activin receptor type-2A precursor

    See identical proteins and their annotated locations for NP_990698.1

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000236
    UniProtKB/Swiss-Prot
    Q90669, Q90745
    UniProtKB/TrEMBL
    A0A8V0YAU9
    Related
    ENSGALP00010013077.1, ENSGALT00010022658.1
    Conserved Domains (2) summary
    cd14141
    Location:196 → 485
    STKc_ACVR2a; Catalytic domain of the Serine/Threonine Kinase, Activin Type IIA Receptor
    pfam01064
    Location:38 → 111
    Activin_recp; Activin types I and II receptor domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052538.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    34110247..34167721
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015289792.4 → XP_015145278.1  activin receptor type-2A isoform X1

    UniProtKB/TrEMBL
    A0A8V0Y294, A0A8V0YAU9
    Related
    ENSGALP00010013072.1, ENSGALT00010022652.1
    Conserved Domains (2) summary
    cd14141
    Location:204 → 493
    STKc_ACVR2a; Catalytic domain of the Serine/Threonine Kinase, Activin Type IIA Receptor
    pfam01064
    Location:38 → 111
    Activin_recp; Activin types I and II receptor domain

  2. XM_040703361.2 → XP_040559295.1  activin receptor type-2A isoform X2

    Conserved Domains (1) summary
    cd14141
    Location:96 → 385
    STKc_ACVR2a; Catalytic domain of the Serine/Threonine Kinase, Activin Type IIA Receptor

  3. XM_046943500.1 → XP_046799456.1  activin receptor type-2A isoform X3

  4. XM_046943501.1 → XP_046799457.1  activin receptor type-2A isoform X3

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052579.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    34027666..34085129
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046921158.1 → XP_046777114.1  activin receptor type-2A isoform X2

  2. XM_046921160.1 → XP_046777116.1  activin receptor type-2A isoform X3

  3. XM_046921156.1 → XP_046777112.1  activin receptor type-2A isoform X1

    UniProtKB/TrEMBL
    A0A8V0Y294

  4. XM_046921157.1 → XP_046777113.1  activin receptor type-2A isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q90669.1 GenPept UniProtKB/Swiss-Prot:Q90669

Gene LinkOut

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