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waslb WASP like actin nucleation promoting factor b [ Danio rerio (zebrafish) ]

Gene ID: 394034, updated on 27-Mar-2024

Summary

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Official Symbol
waslbprovided by ZNC
Official Full Name
WASP like actin nucleation promoting factor bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-718
See related
Ensembl:ENSDARG00000006283 AllianceGenome:ZFIN:ZDB-GENE-040426-718
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
reph; wasl; N-waspb; rephaim; unm_mh22; unm_dmh22; zgc:55478; zgc:77237
Summary
Predicted to enable actin binding activity. Acts upstream of or within myeloid cell differentiation. Predicted to be located in nucleus. Predicted to be active in actin filament. Is expressed in EVL; notochord; periderm; retina; and retinal inner nuclear layer. Orthologous to human WASL (WASP like actin nucleation promoting factor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 4
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (4071138..4111771)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (4070474..4102854)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 37b Neighboring gene transmembrane protein 229A Neighboring gene leiomodin 2 (cardiac) b Neighboring gene ankyrin repeat and SOCS box containing 15b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The cellular architecture and molecular determinants of the zebrafish fusogenic synapse. Luo Z, et al. Dev Cell, 2022 Jul 11. PMID 35709765, Free PMC Article
  2. Latent developmental potential to form limb-like skeletal structures in zebrafish. Hawkins MB, et al. Cell, 2021 Feb 18. PMID 33545089
  3. Genetic Screen for Postembryonic Development in the Zebrafish (Danio rerio): Dominant Mutations Affecting Adult Form. Henke K, et al. Genetics, 2017 Oct. PMID 28835471, Free PMC Article
  4. miR-142-3p acts as an essential modulator of neutrophil development in zebrafish. Fan HB, et al. Blood, 2014 Aug 21. PMID 24990885
  5. A loss of function screen of identified genome-wide association study Loci reveals new genes controlling hematopoiesis. Bielczyk-Maczyńska E, et al. PLoS Genet, 2014 Jul. PMID 25010335, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC55478

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within actin filament organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within dermal bone morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hemopoiesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within myeloid cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within myoblast fusion IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within myoblast fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
WASP like actin nucleation promoting factor b; wiskott-Aldrich syndrome-like
Names
Wiskott-Aldrich syndrome, like
Wiskott-Aldrich syndrome-like b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201059.2 → NP_957353.2  WASP like actin nucleation promoting factor b

    See identical proteins and their annotated locations for NP_957353.2

    Status: PROVISIONAL

    Source sequence(s)
    BC066424
    UniProtKB/TrEMBL
    Q6NYX7
    Related
    ENSDARP00000005823.6, ENSDART00000028016.8
    Conserved Domains (3) summary
    cd01205
    Location:37 → 131
    EVH1_WASP-like; WASP family proteins EVH1 domain
    pfam00786
    Location:215 → 270
    PBD; P21-Rho-binding domain
    pfam02205
    Location:415 → 438
    WH2; WH2 motif

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    4071138..4111771
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021474971.1 → XP_021330646.1  wiskott-Aldrich syndrome-like isoform X2

    UniProtKB/TrEMBL
    A0A8M9Q5U1
    Conserved Domains (3) summary
    cd01205
    Location:9 → 103
    EVH1_WASP-like; WASP family proteins EVH1 domain
    pfam00786
    Location:187 → 244
    PBD; P21-Rho-binding domain
    pfam02205
    Location:387 → 410
    WH2; WH2 motif

  2. XM_005164482.4 → XP_005164539.1  wiskott-Aldrich syndrome-like isoform X1

    UniProtKB/TrEMBL
    A0A8M2BBM4
    Conserved Domains (3) summary
    cd01205
    Location:37 → 131
    EVH1_WASP-like; WASP family proteins EVH1 domain
    pfam00786
    Location:207 → 262
    PBD; P21-Rho-binding domain
    pfam02205
    Location:407 → 430
    WH2; WH2 motif

  3. XM_009299952.3 → XP_009298227.1  wiskott-Aldrich syndrome-like isoform X3

    UniProtKB/TrEMBL
    A0A8M3AR38
    Conserved Domains (2) summary
    pfam00786
    Location:155 → 210
    PBD; P21-Rho-binding domain
    pfam02205
    Location:355 → 378
    WH2; WH2 motif
Nucleotide Protein Strain
Heading Accession and Version

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